Environmental Factors in Obsessive-Compulsive Behavior: Evidence from Discordant and Concordant Monozygotic Twins

Cath, Daniëlle C.; Grootheest, D.S. van; Willemsen, Gonneke; Oppen, Patricia van; Boomsma, Dorret I.

doi:10.1007/s10519-007-9185-9

Cited by 64 publications

(73 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Observation of high obsessive compulsive traits among the FDR and positive correlations between neuroticism and perfectionism (Stumpf and Parker 2000) substantiates the finding of elevated neuroticism in this group. Cath et al (2008) confirm higher genetic load on neuroticism and Lesch et al (1996) also demonstrated an association of neurotic traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region accounting for 7-9 % of inherited variance in personality traits in siblings of OCD. Lower Extraversion score in OCD compared to the controls, describe OCD as reserved, even-paced individuals (Costa and McCrae 1992).…”

Section: Discussionmentioning

confidence: 73%

Exploring the Possibility of Shared Familial Diathesis for Personality in OCD Probands

Tarafder

Mukhopadhyay

2015

Psychol Stud

View full text Add to dashboard Cite

The present study aims to probe into the status of the big five personality factors in the OCD probands and their first degree relatives (FDR) viz a viz community controls and also look into the association of the big five factors with symptom severity and obsessive personality traits. Fifty dyads of probands and FDR and community controls matched on the basis of age, sex and education were assessed on NEO Five Factor Inventory, Yale Brown Obsession Compulsion Scale, Beck Depression Inventory and Leyton Obsessional Inventory to fulfill the aims of the study. The findings reveal higher neuroticism and lower extroversion and conscientiousness in the OCD group as compared to controls, endorsement of greater conscientiousness among the FDR as compared to the case-probands, with Agreeableness and Conscientiousness emerging as predictors associated with obsessive symptoms among OCD probands.

show abstract

Section: Discussionmentioning

confidence: 73%

Exploring the Possibility of Shared Familial Diathesis for Personality in OCD Probands

Tarafder

Mukhopadhyay

2015

Psychol Stud

View full text Add to dashboard Cite

show abstract

“…Zygosity was assessed by a questionnaire using items on physical similarity, blood group and DNA polymorphisms (Willemsen et al, 2013). For both Surveys 6 and 8, OC symptom scores were measured with the Padua Inventory abbreviated (PI-R ABBR; Cath et al, 2008). This 12-item questionnaire has been derived from the Padua Inventory-Revised (PI-R), a widely used 41-item self-report inventory on OC symptoms, with item ratings between 0-4, and five subscales (washing, checking, rumination, precision, and impulses; Sanavio, 1988;van Oppen, 1992).…”

Section: Participants and Proceduresmentioning

confidence: 99%

Genetic and Environmental Contributions to Stability in Adult Obsessive Compulsive Behavior

Zilhão

Smit²,

Braber³

et al. 2014

Twin Res Hum Genet

Self Cite

View full text Add to dashboard Cite

This study investigates the relative contribution of genetic and environmental factors to the stability of obsessive-compulsive (OC) symptoms in an adult population-based sample. We collected data from twin pairs and their siblings, using the Padua Inventory Revised Abbreviated, from the population-based Netherlands Twin Register (NTR) in 2002 (n = 10.134) and 2008 (n = 15.720). Multivariate twin analyses were used to estimate the stability of OC symptoms as a function of genetic and environmental components. OC symptoms were found to be highly stable, with a longitudinal phenotypic correlation of 0.63. Longitudinal broad sense heritability was found to be 56.0%. Longitudinal correlations for genetic (r = 0.58 for additive, r = 1 for non-additive genetic factors) and non-shared environment (r = 0.46) reflected stable effects, indicating that both genes and environment are influencing the stability of OC symptoms in adults. For the first time, evidence is reported for non-additive genetic effects on the stability of OC symptoms. In conclusion, this study showed that OC symptoms are highly stable across time in adults, and that genetic effects contribute mostly to this stability, both in an additive and non-additive way, besides non-shared environmental factors. These data are informative with respect to adult sample selection for future genetic studies, and suggest that gene-gene interaction studies are needed to further understand the dominance effect found in this study.

show abstract

“…2005; Read and Hammersley 2005; Cath et al. 2008; Champagne and Curley 2009; Roullet et al. 2013; Lee et al.…”

Section: Introductionmentioning

confidence: 99%

Early‐life single‐episode sevoflurane exposure impairs social behavior and cognition later in life

et al. 2016

View full text Add to dashboard Cite

BackgroundSingle‐episode anesthetic exposure is the most prevalent surgery‐related incidence among young children in the United States. Although numerous studies have used animals to model the effects of neonatal anesthetics on behavioral changes later on in life, our understanding of the functional consequences to the developing brain in a comprehensive and clinically relevant manner is unclear.MethodsThe volatile anesthetic, sevoflurane (sevo) was administered to C57BL6 postnatal day 7 (P7) mice in a 40% oxygen and 60% nitrogen gas mixture. In order to examine the effects of sevo alone on the developing brain in a clinically relevant manner, mice were exposed to an average of 2.38 ± 0.11% sevo for 2 h. No sevo (control) mice were treated in an identical manner without sevo exposure. Mice were examined for cognition and neuropsychiatric‐like behavioral changes at 1–5 months of age.ResultsUsing the active place avoidance (APA) test and the novel object recognition (NOR) test, we demonstrated that P7 sevo‐treated mice showed a deficit in learning and memory both during periadolescence and adulthood. We then employed a battery of neuropsychiatric‐like behavioral tests to examine social interaction, communication, and repetitive behavior. Interestingly, compared to the no‐sevo–treated group, sevo‐treated mice showed significant reductions in the time interacting with a novel mouse (push–crawl and following), time and interaction in a chamber with a novel mouse, and time sniffing a novel social odor.ConclusionsOur study established that single‐episode, 2‐h sevo treatment during early life impairs cognition later on in life. With this approach, we also observed neuropsychiatric‐like behavior changes such as social interaction deficits in the sevo‐treated mice. This study elucidated the effects of a clinically relevant single‐episode sevo application, given during the neonatal period, on neurodevelopmental behavioral changes later on in life.

show abstract

Environmental Factors in Obsessive-Compulsive Behavior: Evidence from Discordant and Concordant Monozygotic Twins

Cited by 64 publications

References 60 publications

Exploring the Possibility of Shared Familial Diathesis for Personality in OCD Probands

Exploring the Possibility of Shared Familial Diathesis for Personality in OCD Probands

Genetic and Environmental Contributions to Stability in Adult Obsessive Compulsive Behavior

Early‐life single‐episode sevoflurane exposure impairs social behavior and cognition later in life

Contact Info

Product

Resources

About