Environmental hexavalent chromium exposure induces gut microbial dysbiosis in chickens

Li, Aoyun; Ding, Jinxue; Shen, Ting; Han, Zhaoqing; Zhang, Jiabin; Abadeen, Zain Ul; Kulyar, Muhammad Fakhar‐e‐Alam; Wang, Xin; Li, Kun

doi:10.1016/j.ecoenv.2021.112871

Cited by 25 publications

(20 citation statements)

References 41 publications

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“…Previous research demonstrated that the relative abundance of Parabacteroides in the intestine is negatively closely related to obesity and diabetes, showing the vital roles in lipid and glucose metabolism ( Wang et al, 2019 ). Prevotellaceae is responsible for carbohydrate food digestion, which may contribute to more energy capture for host ( Li et al, 2021a ). Ruminococcaceae , a potentially beneficial gut bacteria, contributes to improving immune function and intestinal environment of host ( Gu et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…The poultry gastrointestinal tract is colonized with complex, diverse and changing microbial communities ( Khan et al, 2020 ). Gut microbial communities play an important role in the health and productivity of the host ( Li et al, 2021a ). It is well known that in nutritional, metabolic, physiological and immune processes, the microbiota promotes the digestion and absorption of nutrients, stimulates host immune responses and improves resistance to disease ( Lee et al, 2018 ; Bavananthasivam et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Microbiome analysis reveals the effects of black soldier fly oil on gut microbiota in pigeon

et al. 2022

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The gut microbiota plays a vital roles in poultry physiology, immunity and metabolism. Black soldier fly oil is known to have a positive effect on the gut microbiota. However, the specific effect of black soldier fly oil on the composition and structure of the gut microbiota of the pigeon is unknown. In this experiment, 16S rDNA high-throughput sequencing was performed to study the effect of different doses of black soldier fly oil on the changes of pigeon intestinal microbes. Results indicated that the different doses of black soldier fly oil had no effect on the gut microbial diversity of the pigeon. Although the dominant phyla (Proteobacteria, Firmicutes, Bacteroidetes, and Actinobacteria) and genus (uncultured_bacterium_f_Lachnospiraceae and Desulfovibrio) in control group and experimental group with different doses were the same, the abundances of some beneficial bacteria (Megasphaera, Intestinimonas, Prevotella_9, Lachnospiraceae_UCG-001, Faecalibacterium, Coprococcus_2, Parabacteroides, Megasphaera, Leuconostoc, Prevotellaceae_UCG-001, Lactococcus, Ruminococcaceae_UCG-014, and Coprococcus_2) increased significantly as the concentration of black soldier fly oil increased. Taken together, this study indicated that black soldier fly oil supplementation could improve gut microbial composition and structure by increasing the proportions of beneficial bacteria. Notably, this is the first report on the effects of black soldier fly oil on the gut microbiota of pigeon, which contribute to understanding the positive effects of black soldier fly oil from the gut microbial perspective.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microbiome analysis reveals the effects of black soldier fly oil on gut microbiota in pigeon

et al. 2022

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“…Long-term exposure to Cr(VI) substantially changes the diversity and composition of the chickens' gut microbiome. Bacterial strains that were dominant in the gut microbiota of chickens receiving Cr(VI) were Firmicutes and Actinobacteria, while in the control group these were Firmicutes and Bacteroidetes (Li et al, 2021). The taxonomic analysis of bacteria showed that the relative population size of three classes and seven genera clearly increased, while that of eight classes and thirty genera radically decreased during the induction of Cr(VI).…”

Section: Essentaial Mineralsmentioning

confidence: 95%

Bioactive compounds, antibiotics and heavy metals: Effects on the intestinal structure and microbiome of monogastric animals – a non-systematic review

Winiarska-Mieczan

Kwiecień

Jachimowicz

et al. 2023

Annals of Animal Science

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The intestinal structure and gut microbiota are essential for the animals‘ health. Chemical components taken with food provide the right environment for a specific microbiome which, together with its metabolites and the products of digestion, create an environment, which in turn is affects the population size of specific bacteria. Disturbances in the composition of the gut microbiota can be a reason for the malformation of guts, which has a decisive impact on the animal‘ health. This review aimed to analyse scientific literature, published over the past 20 years, concerning the effect of nutritional factors on gut health, determined by the intestinal structure and microbiota of monogastric animals. Several topics have been investigated: bioactive compounds (probiotics, prebiotics, organic acids, and herbal active substances), antibiotics and heavy metals (essentaial minerals and toxic heavy metals).

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“…These studies illustrated that heavy metal exposure could induce intestinal toxicity by destroying the intestinal barrier in different ways. In recent years, many studies have also shown that long-term exposure to Cr(VI) could cause intestinal damage and adversely affect the intestinal immunity of chickens (24,25). Nevertheless, the mechanism by which Cr(VI) induced intestinal toxicity remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Hexavalent Chromium Exposure Induces Intestinal Barrier Damage via Activation of the NF-κB Signaling Pathway and NLRP3 Inflammasome in Ducks

et al. 2022

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Hexavalent chromium [Cr(VI)] is a dangerous heavy metal which can impair the gastrointestinal system in various species; however, the processes behind Cr(VI)-induced intestinal barrier damage are unknown. Forty-eight healthy 1-day-old ducks were stochastically assigned to four groups and fed a basal ration containing various Cr(VI) dosages for 49 days. Results of the study suggested that Cr(VI) exposure could significantly increase the content of Cr(VI) in the jejunum, increase the level of diamine oxidase (DAO) in serum, affect the production performance, cause histological abnormalities (shortening of the intestinal villi, deepening of the crypt depth, reduction and fragmentation of microvilli) and significantly reduced the mRNA levels of intestinal barrier-related genes (ZO-1, occludin, claudin-1, and MUC2) and protein levels of ZO-1, occludin, cand laudin-1, resulting in intestinal barrier damage. Furthermore, Cr(VI) intake could increase the contents of hydrogen peroxide (H2O2) and malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-18 (IL-18) but decrease the activities of total superoxide dismutase (T-SOD), catalase (CAT), and glutathione reductase (GR), as well as up-regulate the mRNA levels of TLR4, MyD88, NF-κB, TNFα, IL-6, NLRP3, caspase-1, ASC, IL-1β, and IL-18 and protein levels of TLR4, MyD88, NF-κB, NLRP3, caspase-1, ASC, IL-1β, and IL-18 in the jejunum. In conclusion, Cr(VI) could cause intestinal oxidative damage and inflammation in duck jejunum by activating the NF-κB signaling pathway and the NLRP3 inflammasome.

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Environmental hexavalent chromium exposure induces gut microbial dysbiosis in chickens

Cited by 25 publications

References 41 publications

Microbiome analysis reveals the effects of black soldier fly oil on gut microbiota in pigeon

Microbiome analysis reveals the effects of black soldier fly oil on gut microbiota in pigeon

Bioactive compounds, antibiotics and heavy metals: Effects on the intestinal structure and microbiome of monogastric animals – a non-systematic review

Hexavalent Chromium Exposure Induces Intestinal Barrier Damage via Activation of the NF-κB Signaling Pathway and NLRP3 Inflammasome in Ducks

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