Environmental Influences on the Development of Endometriosis

Carmona, Francisco; Martínez-Zamora, Angeles; Bassols, María L.; Balasch, Juan

doi:10.5301/je.5000153

Cited by 5 publications

(3 citation statements)

References 78 publications

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“…Неблагоприятные экологические факторы, в том числе загрязнение окружающей среды вредными продуктами промышленного производства: диоксинами и диоксинподобными соединениями, хлорорганическими пестицидами, фталатами и тяжелыми металлами (особенно кадмий с его эстрогенподобными свойствами, выявленными на моделях животных), также были исследованы в качестве возможных факторов, способствующих развитию эндометриоза, и было показано их значение [58].…”

Section: экологическая теорияunclassified

The external genital endometriosis: theories and molecular investigations (a review)

Adamyan¹,

Фархат²,

Makiyan³

et al. 2015

Probl. reprod.

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Эндометриоз наблюдается у 10% женщин репродуктивного возраста, у пациенток с болевым синдромом встречается заметно чаще и составляет 30-50%, вызывая значительное ухудшение здоровья и репродуктивного исхода. Вопросы клиники, патогенеза и методов лечения наружно-генитального эндометриоза широко представлены в литературе. Однако до настоящего времени нет единого мнения об этиологии и причинах возникновения этого заболевания. В представленном обзоре рассмотрены актуальные вопросы этиологии наружно-генитального эндометриоза и основные теории развития этого заболевания. Ключевые слова: этиология, патогенез эндометриоза, иммунология эндометриоза, стволовые клетки эндометрия.

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Section: экологическая теорияunclassified

The external genital endometriosis: theories and molecular investigations (a review)

Adamyan¹,

Фархат²,

Makiyan³

et al. 2015

Probl. reprod.

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“…Environmental toxicants may be involved as cofactors in the development of endometriosis, and therefore of OMA (14). Dioxins and dioxin-like compounds (DLCs) have been the most investigated (15).…”

Section: Pathogenesis and Mechanisms Of Actionmentioning

confidence: 99%

Endometrioma: From Pathogenesis to Clinical Management

Luisi

Renner

Santulli

2013

Journal of Endometriosis and Pelvic Pain Disorders

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An endometrioma (OMA) is the localization of endometriosis in ovary, and it most often develops as a cyst. The pathogenesis of OMA is still an open question and controversial; a cystic hemorrhagic corpus luteum may be a prerequisite, occurring as a transition to an endometriotic cyst. Inversion and progressive invagination of the ovarian cortex after the accumulation of menstrual debris derived from bleeding of superficial endometriotic implants, located on the ovarian surface and adherent to the peritoneum, is another hypothesis. Gene studies show that WNT4 and FN1 are predisposing genes for OMA development. A role of environmental toxicants in the development of OMA is also under investigation; dioxins and dioxin-like compounds (DLCs), interacting with steroid receptors, are possible factors. Even if women with endometriosis have a 1.5 times greater lifetime risk to develop an ovarian carcinoma, an OMA is not to be considered a preneoplastic lesion. The clinical management of OMAs is complex and should be individualized. Ultrasounds and magnetic resonance imaging (MRI) are sensitive but not specific for diagnosis. Treatment is influenced by patient age, desire for pregnancy, pain severity, cyst dimensions and characteristics (unilateral/bilateral), coexistence of deep endometriosis, previous gynecological or obstetrical history and previous surgery. Laparoscopic surgery is considered the treatment of choice in cases of infertile patients with a large OMA or pain, and in patients not responding to medical therapy. It should be performed with proper techniques by trained surgeons to decrease the damage to the remaining ovarian tissue, and to maintain the ovarian reserve after surgery. A medical hormonal and nonhormonal treatment is used for asymptomatic and/or pain-associated OMA (progestins, estroprogestins and antiinflammatory drugs). Considering the relative high recurrence rate after surgery, a medical treatment should be offered.

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“…Patients with endometriosis have 25–40% concurrent infertility, while 40–87% experience chronic pelvic pain ( 2 ). Genetic predisposition ( 3 ), hormonal irregularities ( 4 ), environmental influences ( 5 ), immune dysregulation ( 6 ) and unique anatomical configurations ( 7 ) are recognized as potential risk factors associated with the onset of endometriosis. The available evidence suggests that immune dysfunction plays an important role in both the pathogenesis of endometriosis and the manifestation of its clinical symptoms ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Causal association of immune cells and endometriosis: a Mendelian randomization study

Fang,

Deng,

Yang

et al. 2024

Front. Endocrinol.

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ObjectiveTo investigate the causal effect of immune cells on endometriosis (EMS), we performed a Mendelian randomization analysis.MethodsMendelian randomization (MR) uses genetic variants as instrumental variables to investigate the causal effects of exposures on outcomes in observational data. In this study, we conducted a thorough two-sample MR analysis to investigate the causal relationship between 731 immune cells and endometriosis. We used complementary Mendelian randomization (MR) methods, including weighted median estimator (WME) and inverse variance weighted (IVW), and performed sensitivity analyses to assess the robustness of our results.ResultsFour immune phenotypes have been found to be significantly associated with the risk of developing EMS: B cell %lymphocyte (WME: OR: 1.074, p = 0.027 and IVW: OR: 1.058, p = 0.008), CD14 on Mo MDSC (WME: OR: 1.056, p =0.021 and IVW: OR: 1.047, p = 0.021), CD14+ CD16− monocyte %monocyte (WME: OR: 0.947, p = 0.024 and IVW: OR: 0.958, p = 0.011), CD25 on unsw mem (WME: OR: 1.055, p = 0.030 and IVW: OR: 1.048, p = 0.003). Sensitivity analyses confirmed the main findings, demonstrating consistency across analyses.ConclusionsOur MR analysis provides compelling evidence for a direct causal link between immune cells and EMS, thereby advancing our understanding of the disease. It also provides new avenues and opportunities for the development of immunomodulatory therapeutic strategies in the future.

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Environmental Influences on the Development of Endometriosis

Cited by 5 publications

References 78 publications

The external genital endometriosis: theories and molecular investigations (a review)

The external genital endometriosis: theories and molecular investigations (a review)

Endometrioma: From Pathogenesis to Clinical Management

Causal association of immune cells and endometriosis: a Mendelian randomization study

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