Environmental lipidomics: understanding the response of organisms and ecosystems to a changing world

Koelmel, Jeremy P.; Napolitano, Michael P.; Ulmer, Candice Z.; Vasiliou, Vasilis; Garrett, Timothy J.; Yost, Richard A.; Prasad, M.N.V.; Pollitt, Krystal J. Godri; Bowden, John A.

doi:10.1007/s11306-020-01665-3

Cited by 32 publications

(22 citation statements)

References 198 publications

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“…Lipidomics is a part of metabolomics, a still-developing field with many techniques to study various types of lipid species that have unique characteristics [132]. The Folch method is the widely used lipid extraction protocol for animal tissues [133].…”

Section: Lipidomicsmentioning

confidence: 99%

“…Lipids are sensitive molecules for environmental science studies since their abundance in any form of life and the lipid profiles can easily change with external stimuli [132,148], such as radiation. Metabolomic studies on the effects of radiation have been widely done; however, in this review, we especially focused on lipidomics studies for radiation effects.…”

Section: Lipidomicsmentioning

confidence: 99%

“…From microorganisms to large animals/plants, every living organism consists of lipids, and individual lipid profiles can be changed by environmental stress [132]. Lipids play an important role in toothed whales' echolocation; however, the combination and profile of these specialized lipids may interact with different stressors that may cause misbehaviors.…”

Section: Acoustic Radiation On Lipid Metabolism In Toothed Whalesmentioning

confidence: 99%

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Multi-Omics Approaches and Radiation on Lipid Metabolism in Toothed Whales

Senevirathna

Asakawa

2021

Life

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Lipid synthesis pathways of toothed whales have evolved since their movement from the terrestrial to marine environment. The synthesis and function of these endogenous lipids and affecting factors are still little understood. In this review, we focused on different omics approaches and techniques to investigate lipid metabolism and radiation impacts on lipids in toothed whales. The selected literature was screened, and capacities, possibilities, and future approaches for identifying unusual lipid synthesis pathways by omics were evaluated. Omics approaches were categorized into the four major disciplines: lipidomics, transcriptomics, genomics, and proteomics. Genomics and transcriptomics can together identify genes related to unique lipid synthesis. As lipids interact with proteins in the animal body, lipidomics, and proteomics can correlate by creating lipid-binding proteome maps to elucidate metabolism pathways. In lipidomics studies, recent mass spectroscopic methods can address lipid profiles; however, the determination of structures of lipids are challenging. As an environmental stress, the acoustic radiation has a significant effect on the alteration of lipid profiles. Radiation studies in different omics approaches revealed the necessity of multi-omics applications. This review concluded that a combination of many of the omics areas may elucidate the metabolism of lipids and possible hazards on lipids in toothed whales by radiation.

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Section: Lipidomicsmentioning

confidence: 99%

Section: Lipidomicsmentioning

confidence: 99%

Section: Acoustic Radiation On Lipid Metabolism In Toothed Whalesmentioning

confidence: 99%

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Multi-Omics Approaches and Radiation on Lipid Metabolism in Toothed Whales

Senevirathna

Asakawa

2021

Life

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“…Lipidomics is an emerging field where hundreds to thousands of lipid molecular species are simultaneously measured qualitatively and quantitatively (Koelmel et al 2020). Lipids participate in metabolic reactions controlling cellular energy balance and also serve as major structural components in membranes, as well as acting as substrates for the generation of signaling compounds and other cellular mediators (Konings et al 2002).…”

Section: Effects Of Dioxins On Lipid Metabolism In Soil Microorganismsmentioning

confidence: 99%

“…Another challenge is selecting a microbe in a natural environment, where it is quite hard to predict its biological/functional behavior in different habitats and as part of a wider microbial community at a given environmental site (Koelmel et al 2020). In this respect, it is worth noting that dioxin biodegradation is a complex biochemical process.…”

Section: Biotechnological Strategies and Future Prospectsmentioning

confidence: 99%

Dioxin impacts on lipid metabolism of soil microbes: towards effective detection and bioassessment strategies

Mahfouz

Mansour

Murphy

et al. 2020

Bioresour. Bioprocess.

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Dioxins are the most toxic known environmental pollutants and are mainly formed by human activities. Due to their structural stability, dioxins persist for extended periods and can be transported over long distances from their emission sources. Thus, dioxins can be accumulated to considerable levels in both human and animal food chains. Along with sediments, soils are considered the most important reservoirs of dioxins. Soil microorganisms are therefore highly exposed to dioxins, leading to a range of biological responses that can impact the diversity, genetics and functional of such microbial communities. Dioxins are very hydrophobic with a high affinity to lipidic macromolecules in exposed organisms, including microbes. This review summarizes the genetic, molecular and biochemical impacts of dioxins on the lipid metabolism of soil microbial communities and especially examines modifications in the composition and architecture of cell membranes. This will provide a useful scientific benchmark for future attempts at soil ecological risk assessment, as well as in identifying potential dioxin-specific-responsive lipid biomarkers. Finally, potential uses of lipid-sequestering microorganisms as a part of biotechnological approaches to the bio-management of environmental contamination with dioxins are discussed.

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Strukturrevision einer weit verbreiteten marinen Sulfonolipidklasse basierend auf deren Isolierung und Totalsynthese

Roman,

Meisinger,

Guillonneau

et al. 2024

Angewandte Chemie

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The cosmopolitan marine Roseobacter clade is of global biogeochemical importance. Members of this clade produce sulfur‐containing amino lipids (SALs) of importance for biofilm formation and marine surface colonization processes. Despite their physiological importance and abundance, SALs have only been explored through genomic mining approaches and lipidomic studies based on mass spectrometry, which left the relative and absolute structures of SALs unresolved hindering progress in biochemical and functional investigations. Here, we report the structural revision of a new group of SALs, which we named cysteinolides, using a combination of analytical techniques, isolation and degradation experiments and total synthetic efforts. Contrary to the previously proposed homotaurine‐based structures, cysteinolides are composed of an N,O‐acylated cysteinolic acid‐containing head group carrying various different (α‑hydroxy) carboxylic acids. We performed the first validated targeted‐network based analysis, which allowed us to map the distribution and structural diversity of cysteinolides across bacterial lineages. Beyond offering structural insights, our research provides SAL standards and validated analytical data. This information holds significance for forthcoming investigations into bacterial sulfonolipid metabolism and biogeochemical nutrient cycling within marine environments.

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Environmental lipidomics: understanding the response of organisms and ecosystems to a changing world

Cited by 32 publications

References 198 publications

Multi-Omics Approaches and Radiation on Lipid Metabolism in Toothed Whales

Multi-Omics Approaches and Radiation on Lipid Metabolism in Toothed Whales

Dioxin impacts on lipid metabolism of soil microbes: towards effective detection and bioassessment strategies

Strukturrevision einer weit verbreiteten marinen Sulfonolipidklasse basierend auf deren Isolierung und Totalsynthese

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