Environmental ototoxicants, a potential new class of chemical stressors

Fábelová, Lucia; Loffredo, Christopher A.; Klánová, Jana; Hilscherová, Klára; Horvat, Milena; Tihányi, Juraj; Richterová, Denisa; Murínová, Ľubica Palkovičová; Wimmerová, Soňa; Sisto, Renata; Moleti, Arturo; Trnovec, T.

doi:10.1016/j.envres.2019.01.042

Cited by 32 publications

(21 citation statements)

References 182 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Due to their characteristic high persistence and bioaccumulation, PCBs are harmful to both animals and humans, even at low levels (Elnar et al, 2015). The toxic effects of DL-PCBs are primarily implemented via activation of the aryl hydrocarbon receptor (AhR) pathway (Du et al, 2019;Fabelova et al, 2019). In the air, PCBs mainly exist as low-chlorinated congeners (Halsall et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

“…The presence of PCB52, known as an indicator PCB, has been demonstrated in food, human blood and milk (Brunelli et al, 2012). Exposure to PCB52 causes alterations in motor activity (Boix et al, 2011), impairment of neurodevelopment (Pessah et al, 2019), and an impaired sense of hearing (Fabelova et al, 2019). In vitro exposure to PCB52 induces excessive generation of reactive oxygen species (ROS) in hepatocytes (Wang et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

N-acetylcysteine alleviates PCB52-induced hepatotoxicity by repressing oxidative stress and inflammatory responses

Zhou

Wang

et al. 2020

PeerJ

View full text Add to dashboard Cite

Polychlorinated biphenyls (PCBs), particularly low chlorinated congeners in our environment, can induce human hepatotoxicity. However, the mechanisms by which PCBs cause hepatotoxicity remain elusive. Moreover, there are no effective treatments for this condition. In this study, 40 μM PCB52 was administered to rat (Brl-3A) and human hepatocytes (L-02) for 48 h following the N-acetylcysteine (NAC)/saline pretreatment. A significant decrease in cell viability was observed in PCB52-treated cells relative to the control. Besides, PCB52 significantly increased reactive oxygen species (ROS) levels and malondialdehyde (MDA) contents, suggesting induction of oxidative stress. The expression of Traf6, MyD88, and Tnf in Brl-3A cells and that of MYD88, TNF, and IL1B in L-02 cells were significantly upregulated by PCB52. Consistently, overexpression of TLR4, MyD88, Traf6, and NF-κB p65 proteins was observed in PCB52-treated cells, indicating activation of inflammatory responses. Nevertheless, no changes in kelch-like ECH-associated protein 1 (keap1), nuclear factor-erythroid 2-related factor (nrf2), and heme oxygenase-1 proteins were observed in PCB52-treated cells, indicating non-activation of the keap1/nrf2 pathway. Pretreatment with NAC significantly ameliorated PCB52 effects on cell viability, ROS levels, MDA contents and expression of inflammatory elements at both RNA and protein levels. However, no changes in keap1, nrf2 and HO-1 protein levels were detected following NAC pretreatment. Taken together, with non-activated keap1/nrf2 pathway, PCB52-induced oxidative stress and inflammatory responses could be responsible for its hepatotoxicity. These effects were effectively attenuated by NAC pretreatment, which scavenges ROS and dampens inflammatory responses. This study might provide novel strategies for the treatment of the PCBs-associated hepatotoxic effects.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

N-acetylcysteine alleviates PCB52-induced hepatotoxicity by repressing oxidative stress and inflammatory responses

Zhou

Wang

et al. 2020

PeerJ

View full text Add to dashboard Cite

show abstract

“…The additives based on halogenated compounds have been the most used ones as flame retardants for thermoplastics until the entry of new environmental regulations that restrict their use. This is due to these flame retardants being found at increasing levels in household dust, human blood and breast milk, and wild animals [15][16][17]. All these circumstances have led to the development of regulations in Europe such as REACH, WEE or ROHS that limit and even prevent the use of many of these substances [12].…”

Section: Introductionmentioning

confidence: 99%

Study and fire test of banana fibre reinforced composites with flame retardance properties

et al. 2020

View full text Add to dashboard Cite

AbstractThe interest in natural fibre reinforced composites is growing in industrial applications due to natural fibres being an attractive alternative to synthetic fibres. However, it is necessary to improve the fire behaviour of the material because natural fibres have a high combustibility. The objective of this work is to evaluate the fire resistance of polymer composites reinforced with natural fibre fabric, using magnesium hydroxide as flame retardant for the polymeric matrix and alkali treatment for the fibre. The types of fabric are banana, banana with cotton and linen; and long banana fibre has been used for the formation of a nonwoven. The fire test is carried out based on ISO 9773 standard and the effect of the additive has been studied, chemical treatment, type of fabric and number of layers. Through statistical analysis, it is concluded that the flame propagation speed has a decreasing relation with respect to the percentage, but it decreases the mechanical properties considerably. In addition, the number of layers and type of fabric influence the fire properties. Finally, it is concluded that composites reinforced with linen fabric have the best mechanical properties, but banana nonwoven with 60% additive has the best fire behaviour.

show abstract

“…Ototoxicity is defined as a substance that has the property of being toxic to the ear, affecting the inner ear or auditory nerve [ 4 ]. Although the literature has suggested that at least 750 different groups of chemicals are potential ototoxicants [ 5 ], few have been tested, and most of them were conducted in the occupational population with noise exposure [ 6 ]. How the ototoxicants affected the general population was less investigated.…”

Section: Introductionmentioning

confidence: 99%

Serum Per- and Polyfluoroalkyl Substances Are Associated with Increased Hearing Impairment: A Re-Analysis of the National Health and Nutrition Examination Survey Data

2020

IJERPH

View full text Add to dashboard Cite

Although studies have shown that per- and polyfluoroalkyl substances (PFAS) are potential environmental ototoxicants, epidemiologic study has been limited. I conducted a cross-sectional study to re-examine the associations between PFAS and hearing impairment. Data were obtained from the National Health and Nutrition Examination Survey (NHANES) 1999–2000, 2003-06, 2009-12, and 2015-16. Perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA) were measured in serum samples. Participants were divided into quartiles for each PFAS. Air conduction pure-tone audiometry was administered. Hearing impairment (1: yes, 0: no) was defined as a hearing threshold of more than 25 dB at 500, 1000, 2000, 4000, and 8000 Hz in the worse ear. I assessed the relation of serum PFAS with hearing impairment by the generalized linear mixed model with a logit link and binary distribution. Tests for linear trend across quartiles of serum PFAS were conducted using the median serum PFAS in each quartile as a continuous variable. After adjusting for age, sex, body mass index, education, ethnicity group, and family income, I found positive correlations between PFOA and hearing impairment at 2000 Hz (p-trend < 0.01) and 3000 Hz (p-trend = 0.02); between PFOS and hearing impairment at 500 Hz (p-trend < 0.01), 2000 Hz (p-trend < 0.0001) and 3000 Hz (p-trend = 0.02); between PFNA and hearing impairment at 2000 Hz (p-trend = 0.05), 3000 Hz (p-trend < 0.01), 4000 Hz (p-trend = 0.02), and 8000 Hz (p-trend < 0.01); between PFHxS and hearing impairment at 500 Hz (p-trend = 0.04), 1000 Hz (p-trend = 0.03), and 2000 Hz (p-trend < 0.01). However, some of the findings were not significant when only comparing the highest with the lowest quartile of PFASs. In conclusion, several background serum PFASs are positively correlated with hearing impairment in the United States adult population.

show abstract

Environmental ototoxicants, a potential new class of chemical stressors

Cited by 32 publications

References 182 publications

N-acetylcysteine alleviates PCB52-induced hepatotoxicity by repressing oxidative stress and inflammatory responses

N-acetylcysteine alleviates PCB52-induced hepatotoxicity by repressing oxidative stress and inflammatory responses

Study and fire test of banana fibre reinforced composites with flame retardance properties

Serum Per- and Polyfluoroalkyl Substances Are Associated with Increased Hearing Impairment: A Re-Analysis of the National Health and Nutrition Examination Survey Data

Contact Info

Product

Resources

About