Environmentally benign one-pot multicomponent synthesis of 1,4-dihydropyridine derivatives applying montmorillonite K10 as reusable catalyst

Reddy, V. Hanuman; Kumari, Avula Krishna; Reddy, Guda Mallikarjuna; Reddy, Y. V. R.; Garcia, Jarem Raul; Zyryanov, Grigory V.; Reddy, N. Bakthavatchala; Rammohan, Aluru

doi:10.1007/s10593-019-02419-3

Cited by 12 publications

(10 citation statements)

References 13 publications

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“…There are many examples for the synthesis of conventional 1,4-DHPs in the literature, which generally involve four components. These include one primary amine, two multiple bonds, and one aldehyde function [ 27 ]. However, one advantage of our study is that we only used three components since the cinnamaldehyde derivatives 3 played the role of two components at the same time, namely that of an aldehyde and that of one multiple bond.…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of C5–C6-unsubstituted 1,4-DHP scaffolds using an efficient Ni–chitosan nanocatalyst under ultrasonic conditions

Basu¹,

Chatterjee²,

Ray³

et al. 2022

Beilstein J. Org. Chem.

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A heterogeneous and magnetically recyclable Ni–chitosan nanocatalyst was synthesized and thoroughly characterized by powder Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) analysis, scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), energy-dispersive X-ray (EDX) spectroscopy, etc. It was effectively utilized in the eco-friendly synthesis of new C5–C6-unsubstituted 1,4-DHPs under ultrasonic irradiation. The important focus of the methodology was to develop an environmentally friendly protocol with a short reaction time and a simple reaction procedure. The other advantages of this protocol are a wide substrate scope, a very good product yield, the use of an eco-friendly solvent and a recyclable nanocatalyst, as well as reaction at room temperature.

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Section: Introductionmentioning

confidence: 99%

Green synthesis of C5–C6-unsubstituted 1,4-DHP scaffolds using an efficient Ni–chitosan nanocatalyst under ultrasonic conditions

Basu¹,

Chatterjee²,

Ray³

et al. 2022

Beilstein J. Org. Chem.

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“…Today it is necessary to take into account the ecological aspect of reaction, especially in the synthesis of heterocyclic rings [10–16] . For the hydroxyisoxazolidine derivatives the “green approach” is often skipped.…”

Section: Introductionmentioning

confidence: 99%

“…Today it is necessary to take into account the ecological aspect of reaction, especially in the synthesis of heterocyclic rings. [10][11][12][13][14][15][16] For the hydroxyisoxazolidine derivatives the "green approach" is often skipped. The most common reagents are alkali hydroxides, metal complexes and toxic organic solvents, such as toluene.…”

Section: Introductionmentioning

confidence: 99%

A Simple Environmentally Friendly Method for the Synthesis of Hydroxyisoxazolidine Derivatives

et al. 2022

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A series of 5-hydroxyisoxazolidines has been successfully synthesized through tris(hydroxymethyl)aminomethane (TRIS) buffered hydroxylamine hydrochloride and α, βunsaturated ketones reaction. This synthetic approach can be considered as environmentally friendly because of the use of non-toxic and non-hazardous reagents at room temperature. The reaction is also metal-free and generates minimum non-toxic waste. The structure of 5-hydroxyisoxazolidines was confirmed not only by extended NMR analysis but by a series of elimination and acetylation reactions. Hydroisoxazolidines are obtained as a mixture of diastereomers (cis-, trans-and N-invertomers). Usually, three sets of 1 HNMR signals are observed for that class of compound (especially for protons H3 and both H4). The analysis of cis-and trans-isomerization of the product 2 b has been conducted.

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“…In the predominant scenario, preparation of innovative potential therapeutics by using environmental favor conditions is a vital venture. The above information kept in mind and our experience in the field of organic research, which includes the biological evaluation of synthetic compounds, [23][24][25] the present research synthesis of pyrazole linked oxadiazole derivatives under ultrasonication method has been taken up. All the resulted compounds were identified by using their proton NMR, carbon NMR, and HRMS spectral data.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of pyrazole tethered oxadiazole and their analogs as potent antioxidant agents

Reddy

Zyryanov

Basha

et al. 2022

Journal of Heterocyclic Chem

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Preparation of organic compounds in environmental favor media always a fresh tool in the synthetic research. If those prepared compounds may possess therapeutically potentiality, then it called as efficient research. Herein, we report the 12 new oxadiazole linked carboxamide pyrazole substances have been synthesized and screened for their free radical scavenging activity by using hydrogen peroxide (H 2 O 2 ), nitric oxide (N 2 O), and diphenyl picryl hydrazide (DPPH) methods. All the compounds displayed reliable biological properties. Among them, compound 8f hold high antioxidant activity may be due to the presence of methoxy group at para position of benzene ring. From the synthetic point of view, this is the novel environment favor method for the synthesis of pyrazole linked oxadiazoles, and the biological results of these compounds may stand as a referee for further development of biologically active pyrazole tethered oxadiazoles.

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Environmentally benign one-pot multicomponent synthesis of 1,4-dihydropyridine derivatives applying montmorillonite K10 as reusable catalyst

Cited by 12 publications

References 13 publications

Green synthesis of C5–C6-unsubstituted 1,4-DHP scaffolds using an efficient Ni–chitosan nanocatalyst under ultrasonic conditions

Green synthesis of C5–C6-unsubstituted 1,4-DHP scaffolds using an efficient Ni–chitosan nanocatalyst under ultrasonic conditions

A Simple Environmentally Friendly Method for the Synthesis of Hydroxyisoxazolidine Derivatives

Synthesis of pyrazole tethered oxadiazole and their analogs as potent antioxidant agents

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