also related to the recent COVID-19 outbreak. This pandemic scenario poses significant threats to public health [1] and there is an urgent need to find robust methods to control the spread of disease in public places or hospital settings. This is important for both viruses and bacteria since COVID-19 patients have an increased risk of cross-contamination, [2] which may increase the risk of developing severe disease and thus induce a higher mortality rate.It is consensual that the spread of viruses and bacteria are mostly related to exposure to respiratory droplets. [3] Nevertheless, the infection through contact with contaminated surfaces or objects (fomites) is an increasing reality and it is still not clear the proportion of this type of transmission for a variety of bacterial infections. In fact, it has been also reported cases of COVID-19 infection potentially attributed to fomite transmission, [4] transmitted between people by touching surfaces on which an ill person has recently coughed or sneezed on. [5] Indeed, high traffic surfaces in public spaces such asThe transmission of bacterial infections through contaminated surfaces is nowadays an increasing source of concern, also related to the current pandemic situation. Functional materials that prevent the adhesion of microorganisms and/ or induce their eradication thus avoiding fomite transmission are highly needed. In this work, a highly antimicrobial hybrid with sensorial capability is developed to be further applied as interactive high traffic surface coatings. The nanocomposite is composed of polyvinylidene fluoride (PVDF), a highly stable fluorinated polymer, incorporating copper core-shell nanowires (NWs). The NWs comprised of copper and shelled with silver is highly antimicrobial, inducing a full kill effect against Escherichia coli and Staphylococcus epidermidis strains but biocompatible towards mammalian cells at concentrations below 0.5 mg mL −1 . Further NWs incorporation on PVDF matrix retains its antimicrobial activity reducing in 6.5 logs the E. coli and 4.5 logs the S. epidermidis. NW/PVDF composites demonstrate suitable mechanical and electrical characteristics for the development of capacitive sensing surfaces, allowing for the fabrication of an antimicrobial capacitive touch sensing matrix for interactive surfaces.