Environmentally‐Responsive Nanogels for siRNA Delivery

Surfactant-Free Synthesis of Biodegradable, Biocompatible, and Stimuli-Responsive Cationic Nanogel Particles

“…Diverse chemical designs of nanogels allow for their responsive swelling to various environmental stimuli such as pH, − temperature, − ionic strength, − reduction, − and light . In addition, the large internal volume allows for encapsulation of various molecules, including small molecules and biomacromolecules like proteins, ,− and DNA or small interfering RNA (siRNA). ,,,, Noncovalent encapsulation of guest molecules by nanogels can be achieved via hydrophobic interactions, − electrostatic interactions, ,, or physical entrapment. ,, These aforementioned properties indicate that nanogels are promising nanoparticulate drug/gene carriers …”