“…The SULT1C2 gene is localized to chromosome 2q11.2 in humans, 9q11 in rats, and 17 in mice, and orthologs have been cloned, expressed, and partially characterized (Freimuth et al, 2000;Xiangrong et al, 2000;Sugimura et al, 2002). SULT1C2 mRNA has been detected in a variety of human tissues, including liver, kidney, thyroid, stomach, and intestine (Her et al, 1997;Dooley et al, 2000;Stanley et al, 2005), whereas in rodents mRNA is predominately expressed in the kidneys, stomach, and liver (Xiangrong et al, 2000;Alnouti and Klaassen, 2006). SULT1C2 catalyzes the sulfonation of the prototypical substrate p-nitrophenol as well as the procarcinogen N-hydroxy-2-acetylaminofluorene, suggesting a role in chemical carcinogenesis (Sakakibara et al, 1998;Xiangrong et al, 2000;Allali-Hassani et al, 2007).…”