Enzymatic reactions and pathway engineering for the production of renewable hydrocarbons

Jaroensuk, Juthamas; Intasian, Pattarawan; Wattanasuepsin, Watsapon; Akeratchatapan, Nattanon; Kesornpun, Chatchai; Kittipanukul, Narongyot; Chaiyen, Pimchai

doi:10.1016/j.jbiotec.2019.12.010

Cited by 21 publications

(24 citation statements)

References 134 publications

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“…97,98 In Thailand, part of the national policy on Bio-, Circular and Green Economy encourages waste-to-energy projects, and microbial conversion of biomass waste to alkane and alkene-based fuels is being explored as an exemplified opportunity. 99 Although the manufacturing of bio-based chemicals and fuels appears to be a promising alternative to conventional petrochemicalbased production, there are various challenges that need to be surmounted for the long-term sustainability of this sector, especially in the Asian region. To support the growing bioeconomy, there will be a need to secure sustainable biomass supply by increasing the cultivation area for crops and lignocellulose biomass.…”

Section: Next-generation Biomanufacturingmentioning

confidence: 99%

“…Advances in genetic engineering of microalgae also opened new avenues for photosynthetic production of biofuels and other valuable chemicals in eukaryotic algae 97,98 . In Thailand, part of the national policy on Bio‐, Circular and Green Economy encourages waste‐to‐energy projects, and microbial conversion of biomass waste to alkane and alkene‐based fuels is being explored as an exemplified opportunity 99 …”

Section: Synthetic Biology‐definition and Stakeholdersmentioning

confidence: 99%

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Future trends in synthetic biology in Asia

et al. 2021

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Synthetic biology research and technology translation has garnered increasing interest from the governments and private investors in Asia, where the technology has great potential in driving a sustainable bio-based economy. This Perspective reviews the latest developments in the key enabling technologies of synthetic biology and its application in bio-manufacturing, medicine, food and agriculture in Asia. Asia-centric strengths in synthetic biology to grow the bio-based economy, such as advances in genome editing and the presence of biofoundries combined with the availability of natural resources and vast markets, are also highlighted. The potential barriers to the sustainable development of the field, including inadequate infrastructure and policies, with suggestions to overcome these by building public-private partnerships, more effective multilateral collaborations and well-developed governance framework, are presented. Finally, the roles of technology, education and regulation in mitigating potential biosecurity risks are examined. Through these discussions, stakeholders from different groups, including academia, industry and government, are expectantly better positioned to contribute towards the establishment of innovation and bioeconomy hubs in Asia.

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Section: Next-generation Biomanufacturingmentioning

confidence: 99%

Section: Synthetic Biology‐definition and Stakeholdersmentioning

confidence: 99%

Future trends in synthetic biology in Asia

et al. 2021

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“…In the final step, the acyl thioester intermediate is reduced by NADPH and aldehyde and NADP + products are then released. 76…”

Section: Carboxylic Acid Reductase (Car)mentioning

confidence: 99%

Fatty alcohol production: an opportunity of bioprocess

Munkajohnpong

Kesornpun

Buttranon

et al. 2020

Biofuels Bioprod Bioref

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Fatty alcohols are widely used for various applications and are found in products ranging from detergents to cosmetics and cleaning agents. Currently, over 3 million tonnes of fatty alcohols are produced per year from bio‐based and petroleum‐based feedstocks through chemical conversion and synthetic processes. However, the environmental impact of current fatty alcohol production processes has become a major concern, and several bioprocesses have emerged as alternative methods for synthesis. These biological processes are environmentally friendly due to their metal‐free nature, low consumption of energy, and mild reaction conditions. This review overviews the current status of fatty alcohol production – both chemical and biological approaches. Our focus is on biological synthesis approaches using biocatalysis and metabolic engineering due to their proven efficacy. Potential downstream processing for these bioprocesses is also presented. © 2020 Society of Chemical Industry and John Wiley & Sons, Ltd

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“…7 For two-step reduction, fatty acids, or their derivatives, are reduced first to fatty aldehydes via reductase enzymes such as carboxylic acid reductase (CAR) or acyl-CoA reductase (ACR). 8 Further reduction to fatty alcohols is then achieved through the activities of other enzymes such as aldehyde reductase or alcohol dehydrogenase. 9 In cells, these pathways can be enhanced via genetic or metabolic engineering to promote greater bioconversion into fatty alcohols.…”

Section: Introductionmentioning

confidence: 99%