Enzymatic Reactive Distillation for the Transesterification of Ethyl Butyrate: Model Validation and Process Analysis

Wierschem, Matthias; Heils, Rene; Schlimper, Stefan; Смирнова, Ирина; Górak, Andrzej; Lutze, Philip

doi:10.1016/b978-0-444-63576-1.50050-9

Cited by 5 publications

(12 citation statements)

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“…There are no reports of ERD with enzymes immobilized in the evaporator (boiler reactor) or in the condenser outlet stream (condenser reactor) due to process‐specific windows of operation. Principally, two enzyme immobilization methods for ERD can be found in literature: entrapment in silica matrix, which is used for coating the structured packings , , or adsorption on anion‐exchange resin , . Literature reports of ERD are presented in Tab.…”

Section: Heterogeneous Vs Homogeneous Biocatalysis: Methods To Stabimentioning

confidence: 99%

Reactive Separations for In Situ Product Removal of Enzymatic Reactions: A Review

Fellechner

Blatkiewicz

Смирнова

2019

Chemie Ingenieur Technik

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The topic of integrating enzymatic reactions with in situ product removal is addressed. Different integrated reactive separations structured accordingly to the corresponding unit operations, i.e., reactive distillation, reactive chromatography, reactive crystallization, and extractive biocatalysis, are discussed. Special attention is given to their realization with homogenous and heterogeneous biocatalysis. Various enzyme immobilization techniques are presented and distinct strategies for installation of heterogeneous catalysts into process equipment are discussed.

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Section: Heterogeneous Vs Homogeneous Biocatalysis: Methods To Stabimentioning

confidence: 99%

Reactive Separations for In Situ Product Removal of Enzymatic Reactions: A Review

Fellechner

Blatkiewicz

Смирнова

2019

Chemie Ingenieur Technik

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“…The model accuracy validation can be observed in Figure 5 Sulzer BX® packing) means that the mass transfer rate is worse than for the conventional packing -as lower the specific surface area, the smaller the mass transfer flow between vapor and liquid phase. This is underpinned by the higher measured HETP values (20% [9] up to 40% [23] increase for coated packing), which imply worse mass transfer.…”

Section: Binary Distillation Systemmentioning

confidence: 99%

“…For the enzyme coated packing, the coating covers the gaps of the packing's wire mesh and therefore changes a i which was not yet described. For the liquid hold-up, a hold-up correlation was established recently [23]. This is a valid assumption because a liquid film is still formed although the packing might now behave as a sheet metal packing.…”

Section: Binary Distillation Systemmentioning

confidence: 99%

“…The self-measured activity of the coating is 4·10 -5 mol BuBu per second and gram of coating at 65 °C and a substrate ratio χ EtBu/BuOH of 10 with a coating thickness of 40 µm. The coating covers not only the wires of the packing, but also seals the gaps between the wires [23]. However, the mass transfer features of the packing are modified which means that hydrodynamics and the mass transfer phenomena need to be experimentally investigated.…”

Section: Chemicalsmentioning

confidence: 99%

“…The description of the binary distillation experiments was reported recently [23]. Table 3 provides the experimental plan summing up four experiments with conventional packing and six experiments with coated packing.…”

Section: Binary Distillation Systemmentioning

confidence: 99%

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Pilot-scale validation of Enzymatic Reactive Distillation for butyl butyrate production

Wierschem

Schlimper

Heils

et al. 2017

Chemical Engineering Journal

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Highlights• Butyl butyrate synthesis by Enzymatic Reactive Distillation is possible• Established rate-based model to describe Enzymatic Reactive Distillation • First time validation for an Enzymatic Reactive Distillation process model AbstractFor enzyme-catalyzed reactions, batch processes using stirred tank reactors are the state-ofthe-art production mode. The yield of the process may be limited by reaction equilibrium, product inhibition of the enzyme, low concentrations and possibly low reaction rates, while the recovery of the product may be limited due to thermodynamic constraints such as azeotropes. Using enzymes in an integrated reactive distillation process can overcome these limitations and provides a cost advantage over classic batch reactor processes.The aim of this paper is i) to report the successful pilot-scale experimental validation of an Enzymatic Reactive Distillation (ERD) process for the synthesis of butyl butyrate and ii) to Pilot-Scale Validation of Enzymatic Reactive Distillation for Butyl Butyrate ProductionWierschem et al.2 establish a rate-based model for conceptual process design which can be quickly adapted to other systems.The main novelty is the application of a continuous RD column with enzymes as a heterogeneous catalyst provided in two different types of catalytic packing: loosely filled immobilized enzyme beads in standard packings with catalyst pockets and gauze packings with catalytic coating.Experimental pilot-scale experiments show the feasibility of ERD and allow the comparison of the different packing types based on catalytic performance as well as stability.Furthermore, these experiments are used to validate a predictive rate-based model to describe ERD which can be used to check the sensitivity of process and design parameters as well as to provide a quick adaption to other systems for quick evaluation.

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Enzymatic catalyzed reactive dividing wall column: Experiments and model validation

Egger

Fieg

2016

AIChE Journal

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A novel process for the integration of chemical reaction and product separation is proposed: the enzymatic catalyzed reactive dividing wall column (eRDWC). The eRDWC combines the highly integrated and complex reactive dividing wall column (RDWC) with the use of a very selective enzymatic catalyst. This apparatus enables the simultaneous production and separation of up to 4 pure product streams. Comprehensive experiments with the reference system of a hexanol and butyl acetate transesterification in a DN 65 pilot scale column show the feasibility of stable steady state operations for this process. A rigorous model for the plant design of an eRDWC wall column is developed. The reaction kinetics and vapor‐liquid‐equilibria for the reference system are measured and implemented in the model. The model is successfully validated using the acquired experimental data. The application of enzymes in continuous reactive distillation processes has the potential to increase the selectivity at milder process conditions. © 2016 American Institute of Chemical Engineers AIChE J, 63: 2198–2211, 2017

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Enzymatic Reactive Distillation for the Transesterification of Ethyl Butyrate: Model Validation and Process Analysis

Cited by 5 publications

References 5 publications

Reactive Separations for In Situ Product Removal of Enzymatic Reactions: A Review

Reactive Separations for In Situ Product Removal of Enzymatic Reactions: A Review

Pilot-scale validation of Enzymatic Reactive Distillation for butyl butyrate production

Enzymatic catalyzed reactive dividing wall column: Experiments and model validation

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