Enzymatic ring opening polymerization of ω-pentadecalactone using supercritical carbon dioxide

Polloni, André E.; Veneral, Josamaique G.; Rebelatto, Evertan A.; Oliveira, Débora de; Oliveira, J. Vladimir; Araújo, Pedro Henrique Hermes de; Sayer, Cláudia

doi:10.1016/j.supflu.2016.09.019

Cited by 43 publications

(22 citation statements)

References 43 publications

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“…358 This group later studied the use of supercritical fluids in this reaction, with lower yields and molecular size (around 60 wt% and 33 000 g mol −1 ). 359 Another paper shows the polymerization of ε-caprolactone using lipase N435 as a catalyst. 360 The successful enzymatic copolymerizations via ring opening of ε-thiocaprolactone and ε-caprolactone catalyzed by N435 have been reported.…”

Section: Lewatit Vp Oc 1600mentioning

confidence: 99%

Novozym 435: the “perfect” lipase immobilized biocatalyst?

Ortíz

Ferreira

Barbosa

et al. 2019

Catal. Sci. Technol.

471

360

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Section: Lewatit Vp Oc 1600mentioning

confidence: 99%

Novozym 435: the “perfect” lipase immobilized biocatalyst?

Ortíz

Ferreira

Barbosa

et al. 2019

Catal. Sci. Technol.

471

360

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“…Wang et al (193) have used cheap, idle, unharmful, and non-flammable supercritical carbon dioxide (scCO 2 ) to supplant the toxic solvents which have been used for the ROP of PGA in suspension polymerization. In addition to this, the elimination of scCO 2 can be done simply by system depressurization and also improves enzyme activity and stability (194). This property of scCO 2 has been used for ROP of macrolactone globalide, which otherwise is a difficult process and results in low molecular weight polymers.…”

Section: The Modern Methods Of Synthesis Of Bpsmentioning

confidence: 99%

A glimpse of biodegradable polymers and their biomedical applications

Shah

Vasava

2019

E-Polymers

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Over the past two decades, biodegradable polymers (BPs) have been widely used in biomedical applications such as drug carrier, gene delivery, tissue engineering, diagnosis, medical devices, and antibacterial/antifouling biomaterials. This can be attributed to numerous factors such as chemical, mechanical and physiochemical properties of BPs, their improved processibility, functionality and sensitivity towards stimuli. The present review intended to highlight main results of research on advances and improvements in terms of synthesis, physical properties, stimuli response, and/or applicability of biodegradable plastics (BPs) during last two decades, and its biomedical applications. Recent literature relevant to this study has been cited and their developing trends and challenges of BPs have also been discussed.

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“…Novozym®435-catalyzed ROP of ω-PDL was applied in scCO 2 in the presence of a co-solvent (dichloromethane or chloroform), synthesizing poly-ω-PDL with M w value up to 33,000 to 66,600 Da (PDI > 2). [125] The presence of co-solvent (with monomer to co-solvent mass ratio varying from 1 : 2 to 2 : 1 and (monomer + co-solvent) to scCO 2 mass ratio varying from 1 : 2 to 2 : 1) generated higher molecular weight poly-ω-pentadecalactone and higher reaction yields (with chloroform facilitating higher increase in reaction yields than dichloromethane). This co-solvent method was applied to the continuous Novo-zym®435-catalyzed synthesis of poly-ɛ-CL in PBR, [126] using a mixture of ɛ-CL (50 wt%) and dichloromethane (50 wt%) and pressurized fluids as solvents (2 : 1 solvent/mixture mass ratio).…”

Section: Erop Of Lactones In Supercritical Carbon Dioxide (Scco 2 ) Amentioning

confidence: 99%

Enzymatic Ring‐Opening Polymerization of Lactones: Traditional Approaches and Alternative Strategies

et al. 2019

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Biodegradable polymers such as polylactides and other polylactones and their synthesis gain progressively importance. Enzymatic ring‐opening polymerization (eROP) is the next step sustainable synthesis of polyesters, also suitable for biomedical applications due to high selectivity and lack of toxic agents. The possibility for applying diverse reaction media ranging from traditional bulk and organic media to greener alternatives such as aqueous media, ionic liquids, and supercritical fluids may allow designing alternative non‐conventional processes with less environmental footprint. Target success criteria such as high molecular weight and uniformity of polymers, and conversion of monomers have to be carefully evaluated in these diverse media. Herein we discuss the influence of different reaction media and conditions such as water content, temperature and time on the polymer sizes achieved in eROPs and various approaches to improve the molecular weight and uniformity of polymers.

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Enzymatic ring opening polymerization of ω-pentadecalactone using supercritical carbon dioxide

Cited by 43 publications

References 43 publications

Novozym 435: the “perfect” lipase immobilized biocatalyst?

Novozym 435: the “perfect” lipase immobilized biocatalyst?

A glimpse of biodegradable polymers and their biomedical applications

Enzymatic Ring‐Opening Polymerization of Lactones: Traditional Approaches and Alternative Strategies

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