Enzyme‐Activatable Polypeptide for Plasma Membrane Disruption and Antitumor Immunity Elicitation

Abstract

In addition, the principal components of plasma membrane bridge intracellular signals with extracellular messages (e.g., cytokines, hormones, and ligands), which exert profound influence on the regulation of cellular signaling networks. [3,4] Severe injuries in cytomembrane may cause acute pathologies and pose an instant threat to cell survival, owing to the vast change of intracellular landscape upon cytosolic leakage. [5,6] Specifically, the pervasive dyshomeostasis may give rise to deleterious proteolysis, calcium imbalance, and osmotic pressure, ultimately causing cell death. [7,8] Thus far, the disruption of cytomembrane integrity can be categorized into the following two approaches: chemical damage and physical disruption.

Tumor Cell-Targeting and Tumor Microenvironment–Responsive Nanoplatforms for the Multimodal Imaging-Guided Photodynamic/Photothermal/Chemodynamic Treatment of Cervical Cancer

“…In particular, the red-shifted ICG peaks of HMnO 2 @ICG were ascribed to the conversion of ICG monomers to J aggregates via non-covalent chemistry. 49 The characteristic ICG absorption peaks of M-HMnO 2 @ICG were consistent with those of HMnO 2 @ICG, indicating that the ICG-loaded NPs maintain functional integrity after physical coextrusion and cell membrane encapsulation.…”

Nanoplatform-based strategies for enhancing the lethality of current antitumor PDT

“…The most prominent function of the plasma membrane on cells is to provide a protective screen for the intracellular physiological environment, and the serious damage to the plasma membrane will undoubtedly cause the death of tumor cells. 71–73 Based on this, many plasma membrane-targeting PDT strategies have been proposed to widely destroy the integrity of the membrane of tumor cells and then greatly boost the tumor-killing effect of PDT. Among these studies, the aliphatic chain was the commonly used tool to achieve the insertion of membrane structures.…”

Self-assembled branched polypeptides as amelogenin mimics for enamel repair

“…In recent years, branched poly(amido amine) derivatives have been reported to exhibit self-assembly behavior similar to Ame and effectively mediate the crystallization process of HAP, which demonstrates that the branched polymer chain can enhance the complexity and diversity of self-assembly, making it become a promising biomimetic structure of a three-dimensional protein. 48–54 Accordingly, we chose branched poly(γ-benzyl- l -glutamate) (PBLG) as the mimic of the Ame's N-terminal domain, a hydrophobic poly(amino acid) with excellent self-assembling capability, great degradability and superior biocompatibility, 55–64 which was coupled with the hydrophilic C-Ame segment to form a complete Ame mimic (Fig. 1).…”