Enzyme-Linked Immunosorbent Assay for Measuring Antibodies to Pneumococcal Polysaccharides for the PNEUMOVAX 23 Vaccine: Assay Operating Characteristics and Correlation to the WHO International Assay

The clinical relevance of IgM and IgA anti-pneumococcal polysaccharide ELISA assays in patients with suspected antibody deficiency

“…Patients with SPAD suffer from recurrent ear-nosethroat (ENT) and airway infections with encapsulated bacteria. Pneumococcal polysaccharide (PnPS) antibodies can be measured as the cumulative titre of antibodies to all 23 serotypes present in the PnPS vaccine (hereafter called 'anti-PnPS IgG assay'), or as individual serotype-specific antibodies (hereafter called 'serotype-specific PnPS IgG testing') [4][5][6]. Such serotype-specific PnPS IgG testing is expensive, not widely available, and interpretation of the results has proved to be challenging [7,8].…”