Enzyme‐Modified Hydrogel Coatings with Self‐Cleaning Abilities for Low Fouling PDMS Devices

Jackson

et al. 2016

Adv Funct Materials

Self Cite

Triggerable devices capable of on‐demand, controlled release of therapeutics are attractive options for the treatment of local diseases because of their potential to enhance therapeutic effectiveness with reduced systemic toxicity. Here, the design and fabrication of a miniaturized device, termed a microspouter, is described. This device is shown to provide active and precise control of localized delivery of drugs on demand. The microspouter is composed of a magnetic sponge to provide the force for drug release through magnetic field‐induced reversible deformation, a reservoir for the sponge installation and drug loading, and a soft membrane for sealing the device. Following application of a magnetic field to the microspouter, the shrinking of the sponge may trigger a spouting of drug through a membrane's microaperture. The efficiency of the device in controlling the dose and time course of drug release under different external magnetic fields has been demonstrated using methylene blue and docetaxel as model drugs. Additionally, the microspouter is found to have low background drug leakage that allows for tunable drug release in an ex vivo implantation experiment. All the results confirm the microspouter as a potential device for safe, long‐time, and controlled drug release in local disease treatment.

Section: Resultsmentioning

confidence: 99%

Active Regulation of On‐Demand Drug Delivery by Magnetically Triggerable Microspouters

Shademani

Jackson

et al. 2016

Adv Funct Materials

Self Cite

“…Furthermore, others have attempted to combine these materials with components that have active antimicrobial properties, such as to prepare materials with two synergistic mechanisms; fouling resistance plus antimicrobial properties 5,24 www.nature.com/scientificreports/ polymer-metal composite materials, attention has also turned towards using enzymes as an active proteindegrading or antimicrobial component [25][26][27] . For example, Chiao and co-workers developed PEG-based hydrogel coatings with immobilized protease, which showed resistance towards fouling by model proteins using two synergistic mechanisms; both the intrinsic low-fouling properties of the PEG material and enzymatic protein degradation 28 . Similarly, lysostaphin, an enzyme which can break down the pentaglycine crosslinks in staphylococcal peptidoglycan, has been incorporated into injectable PEG-based hydrogel materials for the treatment of bacterial orthopaedic infections 29 .…”

Section: Honey-inspired Antimicrobial Hydrogels Resist Bacterial Colomentioning

confidence: 99%

Honey-inspired antimicrobial hydrogels resist bacterial colonization through twin synergistic mechanisms

Gunatillake

et al. 2020

Sci Rep

Inspired by the interesting natural antimicrobial properties of honey, biohybrid composite materials containing a low-fouling polymer hydrogel network and an encapsulated antimicrobial peroxide-producing enzyme have been developed. These synergistically combine both passive and active mechanisms for reducing microbial bacterial colonization. The mechanical properties of these materials were assessed using compressive mechanical analysis, which revealed these hydrogels possessed tunable mechanical properties with Young’s moduli ranging from 5 to 500 kPa. The long-term enzymatic activities of these materials were also assessed over a 1-month period using colorimetric assays. Finally, the passive low-fouling properties and active antimicrobial activity against a leading opportunistic pathogen, Staphylococcus epidermidis, were confirmed using bacterial cell counting and bacterial adhesion assays. This study resulted in non-adhesive substrate-permeable antimicrobial materials, which could reduce the viability of planktonic bacteria by greater than 7 logs. It is envisaged these new biohybrid materials will be important for reducing bacterial adherence in a range of industrial applications.

“…[101][102][103][104][105][106] Several chemical and physical strategies have been employed to improve their performance. Bioinspired gel surfaces have been intensively used as antibiofouling coatings.…”

Section: Antibiofoulingmentioning

confidence: 99%

“…Bioinspired gel surfaces have been intensively used as antibiofouling coatings. Although the antibiofouling property of hydrogels has been used for a long time, they still fail to meet the requirements of practical applications, such as long‐term performance and durability in harsh environments . Several chemical and physical strategies have been employed to improve their performance.…”

Section: Emerging Applicationsmentioning

confidence: 99%

Recent Advances in Bioinspired Gel Surfaces with Superwettability and Special Adhesion

Zhao

et al. 2019

Advanced Science

Engineering surface wettability is of great importance in academic research and practical applications. The exploration of hydrogel‐based natural surfaces with superior properties has revealed new design principles of surface superwettability. Gels are composed of a cross‐linked polymer network that traps numerous solvents through weak interactions. The natural fluidity of the trapped solvents confers the liquid‐like property to gel surfaces, making them significantly different from solid surfaces. Bioinspired gel surfaces have shown promising applications in diverse fields. This work aims to summarize the fundamental understanding and emerging applications of bioinspired gel surfaces with superwettability and special adhesion. First, several typical hydrogel‐based natural surfaces with superwettability and special adhesion are briefly introduced, followed by highlighting the unique properties and design principles of gel‐based surfaces. Then, the superwettability and emerging applications of bioinspired gel surfaces, including liquid/liquid separation, antiadhesion of organisms and solids, and fabrication of thin polymer films, are presented in detail. Finally, an outlook on the future development of these novel gel surfaces is also provided.