Enzyme-processed Korean Red Ginseng extracts protects against skin damage induced by UVB irradiation in hairless mice

Abstract

UV irradiation is the main factor contributing to skin damages that are associated with an excessive production of matrix-degrading metalloproteinase (MMP)-1 and a deficient expression of collagens. To date, red ginseng has been revealed to possess many biomedical effects, such as anti-aging, anti-oxidation, and anti-inflammatory. In this study, we prepared the Korean Red Ginseng extracts treated with enzyme (KRGE) and investigated the effects of dietary KRGE on the formation of wrinkles generated by UVB irradiation in hairless mice. It was found that KRGE inhibited the UVB-induced formation of wrinkles, epidermal thickness, and skin dryness in hairless mice. Further results also showed that KRGE attenuated UVB-induced MMP-1 level, while accelerated procollagen type I, transforming growth factor-β1 secretion. Interestingly, the expression of profilaggrin and filaggrin in both the epidermis and dermis were decreased due to UVB exposure and reversed by KRGE. The KRGE 0.06% was prior to KRGE 0.24%. In view of these results, which indicated that KRGE protected skin from UVB-induced photodamages, which may not only mediated by regulating of MMP-1 and procollagen type I, but also by increasing the production of profilaggrin and filaggrin. In conclusion, our results suggest that KRGE may be a promising agent for the treatment of skin photodamages. The challenge of KRGE will be expected as cosmeceuticals and nutraceuticals in order to intervene in aging-related degenerative skin changes.

Coriander Leaf Extract Exerts Antioxidant Activity and Protects Against UVB-Induced Photoaging of Skin by Regulation of Procollagen Type I and MMP-1 Expression

“…36 In an in vivo study of human skin, chronic UVB exposure was found to decrease the production of procollagen type I, leading to collagen loss and increased wrinkling, skin thickening, and reduced skin elasticity. 28,37 Using histological techniques, we observed the changes associated with photoaging in hairless mice treated with CSE. Specifically, mice treated with CSE had thinner epidermal layers and denser collagen fibers compared with untreated mice (Fig.…”

Efficacy and Safety of Enzyme-Modified Panax ginseng for Anti-Wrinkle Therapy in Healthy Skin: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study

“…However, the overall change in R4 was greater in the EG-treated group than in the 2 placebo group (Table 6). EG treatment decreased the arithmetic roughness average (R5) 3 value (down to 0.01±0.01 A.U. ), whereas placebo did not (Table 7).…”

“…10 2 Global photodamage scores of eye wrinkles were diminished by treatment with EG. 3 Crow's feet wrinkles in the EG treatment group appeared thinner and dimmer in photographs 4 compared with placebo. These results suggest that topical application of EG may have anti-5 wrinkle effects.…”

“…Baseline severity of global All volunteers were instructed about application of the formulation, and crow's feet wrinkle 1 selected as the testing area. Active formulation (EG) was applied on the left or right foot 2 manifesting signs of crow's feet, and the placebo was applied on the other foot, respectively, 3 twice daily (morning and night) for 12 weeks. Before application, subjects were asked to 4 wash their skin using the same mild facial nickel-tested cleanser.…”

“…EG and placebo 2 formulations were identical in color, fragrance, and packaging. The composition of 3 formulations was presented in supplementary 1. 4 5 Subjects and study design 6 In this randomized, double-blind study, 23 healthy Korean women aged 30 to 65 years 7 presenting with crow's feet wrinkles were enrolled and 22 women recruited as participants.…”