Enzyme-regulated NO programmed to release from hydrogel-forming microneedles with endogenous/photodynamic synergistic antibacterial for diabetic wound healing

Wang, Peng-Hui; Pu, Yajie; Ren, Yanhan; Kong, Wenhao; Xu, Liang; Zhang, Wenjie; Shi, Tianqi; Ma, Juping; Li, Shuang; Tan, Xiaoyan; Chi, Bo

doi:10.1016/j.ijbiomac.2022.12.063

Cited by 19 publications

(5 citation statements)

References 49 publications

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“…MNs incorporating FE III TA NPs exhibited faster recovery in diabetic mice compared to MNs without this substance. Wound biopsies conducted at multiple time points, specifically 3, 7, and 14 days, demonstrated significant reductions in TNF-α and IL-6, confirming the robust anti-inflammatory effect of FE III TA NPs (Wang et al, 2023a). MNs augmented with FE 2 O 3 /polydopamine (PDA) exhibited a dosedependent reduction in the count of E. coli and S. aureus colonies in culture dishes which also effectively inhibited the formation of their bacterial biofilm.…”

Section: Other Metal Elementsmentioning

confidence: 71%

“…Additionally, its network exhibits a photothermal conversion efficiency of up to 77.3% (Liu et al, 2018). In vitro experiments demonstrated that when treated with NIR, increasing the concentration of Fe III TA NPs from 0% to 5% resulted in an enlargement of the inhibition zone diameter for E. coli from 1.83 ± 0.03 cm to 2.16 ± 0.06 cm, and for S. aureus from 1.34 ± 0.01 cm to 1.62 ± 0.035 cm (Wang et al, 2023a). It is worth noting that although PTT directly contributes to antimicrobial activity, photothermal also facilitates the dissolution of MNs.…”

Section: Photothermal Therapymentioning

confidence: 99%

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Metallic elements combine with herbal compounds upload in microneedles to promote wound healing: a review

Tang,

Li,

You

et al. 2023

Front. Bioeng. Biotechnol.

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Wound healing is a dynamic and complex restorative process, and traditional dressings reduce their therapeutic effectiveness due to the accumulation of drugs in the cuticle. As a novel drug delivery system, microneedles (MNs) can overcome the defect and deliver drugs to the deeper layers of the skin. As the core of the microneedle system, loaded drugs exert a significant influence on the therapeutic efficacy of MNs. Metallic elements and herbal compounds have been widely used in wound treatment for their ability to accelerate the healing process. Metallic elements primarily serve as antimicrobial agents and facilitate the enhancement of cell proliferation. Whereas various herbal compounds act on different targets in the inflammatory, proliferative, and remodeling phases of wound healing. The interaction between the two drugs forms nanoparticles (NPs) and metal-organic frameworks (MOFs), reducing the toxicity of the metallic elements and increasing the therapeutic effect. This article summarizes recent trends in the development of MNs made of metallic elements and herbal compounds for wound healing, describes their advantages in wound treatment, and provides a reference for the development of future MNs.

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Section: Other Metal Elementsmentioning

confidence: 71%

Section: Photothermal Therapymentioning

confidence: 99%

Metallic elements combine with herbal compounds upload in microneedles to promote wound healing: a review

Tang,

Li,

You

et al. 2023

Front. Bioeng. Biotechnol.

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“…In vivo STZ-induced diabetic SD rats Diabetic wound Wang, P. [34] 2022 𝛾-PGA, Wang, P. [54] 2023 Gelatin Iron/tannic acid composite nanoparticles…”

Section: Passive Deliverymentioning

confidence: 99%

“…Despite its lack of control, its widespread use in research. iii) Actively triggered MNP is controlled by artificial stimulation, such as near-infrared laser (NIR) irradiation, [54,[56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71] external pump, [72] UV, [73] and sonophoresis [74,75] to manipulate the release or pause of the loaded drug when needed. iv) Compared to actively triggered, the stimuli-responsive is more intelligent.…”

Section: Introductionmentioning

confidence: 99%

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Targeting Diverse Wounds and Scars: Recent Innovative Bio‐design of Microneedle Patch for Comprehensive Management

Zhuang,

Wang,

Feng

et al. 2023

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Wounds and the subsequent formation of scars constitute a unified and complex phased process. Effective treatment is crucial; however, the diverse therapeutic approaches for different wounds and scars, as well as varying treatment needs at different stages, present significant challenges in selecting appropriate interventions. Microneedle patch (MNP), as a novel minimally invasive transdermal drug delivery system, has the potential for integrated and programmed treatment of various diseases and has shown promising applications in different types of wounds and scars. In this comprehensive review, the latest applications and biotechnological innovations of MNPs in these fields are thoroughly explored, summarizing their powerful abilities to accelerate healing, inhibit scar formation, and manage related symptoms. Moreover, potential applications in various scenarios are discussed. Additionally, the side effects, manufacturing processes, and material selection to explore the clinical translational potential are investigated. This groundwork can provide a theoretical basis and serve as a catalyst for future innovations in the pursuit of favorable therapeutic options for skin tissue regeneration.

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Local Delivery of Glabridin by Biomolecular Microneedle to Accelerate Infected Wound Healing

Chen,

Hu,

Wang

et al. 2023

Adv Healthcare Materials

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Applying antibacterial polymers and pro‐regenerative small molecules are two individual strategies for accelerating wound healing. However, integrating those two unique approaches into one therapeutic platform that meets clinical requirements is still a challenge. Herein, a series of antibacterial gelatin methacrylate (GelMA)/ε‐polylysine (ε‐PL) composite hydrogels (termed as GP‐n HGs, n = 0, 10, 20 and 30, respectively) were innovatively fabricated by ultraviolet light (UV) crosslinking. The GP‐n HGs were proved to be broad‐spectrum antibacterial and biocompatible. Among those GP‐n HGs, the GP‐20 HG was selectively processed into microneedle following a mold‐casting method. Then, the glabridin was loaded into those needles to produce composite microneedle termed GP‐20@Gla MN. An S. aureus‐infected full‐thickness defect model in rats was created to evaluate the wound‐healing effect of GP‐20@Gla MN. Furthermore, an RNA sequencing assay was performed to explore the possible molecular mechanisms of glabridin in promoting tissue regeneration, and many positive routes have been summarized. This work is of significant novelty in fulfilling complex clinical needs by simultaneously optimizing the advanced microneedles' chemical compositions and physical structures. This work will provide a promising therapeutic platform for treating infected and chronic wounds.This article is protected by copyright. All rights reserved

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Enzyme-regulated NO programmed to release from hydrogel-forming microneedles with endogenous/photodynamic synergistic antibacterial for diabetic wound healing

Cited by 19 publications

References 49 publications

Metallic elements combine with herbal compounds upload in microneedles to promote wound healing: a review

Metallic elements combine with herbal compounds upload in microneedles to promote wound healing: a review

Targeting Diverse Wounds and Scars: Recent Innovative Bio‐design of Microneedle Patch for Comprehensive Management

Local Delivery of Glabridin by Biomolecular Microneedle to Accelerate Infected Wound Healing

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