Enzyme-triggered on-demand release of a H2O2-self-supplying CuO2@Fe3O4 nanoagent for enhanced chemodyamic antimicrobial therapy and wound healing

Zhang, Sijie; Hussain, Sameer; Tang, Yuhai; Wang, Kaili; Wang, Xingyan; Zhang, Long; Liao, Yuheng; Wang, Chen; Hao, Yi; Gao, Ruixia

doi:10.1039/d3tb02762g

Cited by 8 publications

(1 citation statement)

References 53 publications

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“…26 The carboxyl group can be oxidised by H 2 O 2 to form a peroxycarboxylic group, which in turn is catalyzed by metal ions to form 1 O 2 . 27 In addition, H 2 O 2 could be catalyzed to generate oxygen under the action of catalysts such as MnO 2 , 28,29 hydrogen peroxidase catalase, 30,31 and iridium oxide. 32 Then the supply of oxygen could adjust the type and differentiation of immune cells and further reconstruct the tumor environment.…”

Section: Introductionmentioning

confidence: 99%

Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Zhang,

Li,

Tang

et al. 2024

Biomater. Sci.

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Section: Introductionmentioning

confidence: 99%

Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Zhang,

Li,

Tang

et al. 2024

Biomater. Sci.

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Application of Drug Delivery System Based on Nanozyme Cascade Technology in Chronic Wound

Wang,

Li,

Liu

et al. 2024

Adv Healthcare Materials

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Chronic wounds are characterized by long‐term inflammation, including diabetic ulcers, traumatic ulcers, etc., which provide an optimal environment for bacterial proliferation. At present, antibiotics are the main clinical treatment method for chronic wound infections. However, the overuse of antibiotics may accelerate the emergence of drug‐resistant bacteria, which poses a significant threat to human health. Therefore, there is an urgent need to develop new therapeutic strategies for bacterial infections. Nanozyme‐based antimicrobial therapy (NABT) is an emerging antimicrobial strategy with broad‐spectrum activity and low drug resistance compared to traditional antibiotics. NABT has shown great potential as an emerging antimicrobial strategy by catalyzing the generation of reactive oxygen species (ROS) with its enzyme‐like catalytic properties, producing a powerful bactericidal effect without developing drug resistance. Nanozyme‐based cascade antimicrobial technology offers a new approach to infection control, effectively improving antimicrobial efficacy by activating cascades against bacterial cell membranes and intracellular DNA while minimizing potential side effects. However, it is worth noting that this technology is still in the early stages of research. This article comprehensively reviews wound classification, current methods for the treatment of wound infection, different types of nanozymes, the application of nanozyme cascade reaction technology in antimicrobial therapy, and future challenges and prospects.

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Biomedical applications of stimuli‐responsive nanomaterials

Chen,

Wu,

Chen

2024

MedComm

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Nanomaterials have aroused great interests in drug delivery due to their nanoscale structure, facile modifiability, and multifunctional physicochemical properties. Currently, stimuli‐responsive nanomaterials that can respond to endogenous or exogenous stimulus display strong potentials in biomedical applications. In comparison with conventional nanomaterials, stimuli‐responsive nanomaterials can improve therapeutic efficiency and reduce the toxicity of drugs toward normal tissues through specific targeting and on‐demand drug release at pathological sites. In this review, we summarize the responsive mechanism of a variety of stimulus, including pH, redox, and enzymes within pathological microenvironment, as well as exogenous stimulus such as thermal effect, magnetic field, light, and ultrasound. After that, biomedical applications (e.g., drug delivery, imaging, and theranostics) of stimuli‐responsive nanomaterials in a diverse array of common diseases, including cardiovascular diseases, cancer, neurological disorders, inflammation, and bacterial infection, are presented and discussed. Finally, the remaining challenges and outlooks of future research directions for the biomedical applications of stimuli‐responsive nanomaterials are also discussed. We hope that this review can provide valuable guidance for developing stimuli‐responsive nanomaterials and accelerate their biomedical applications in diseases diagnosis and treatment.

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Enzyme-triggered on-demand release of a H₂O₂-self-supplying CuO₂@Fe₃O₄ nanoagent for enhanced chemodyamic antimicrobial therapy and wound healing

Abstract: Nanoagents for chemodynamic therapy (CDT) hold a promising future in the field of antimicrobials, especially copper peroxide (CuO2) (CP) nanomaterials which have garnered significant attention due to their ability to...

Cited by 8 publications

References 53 publications

Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Application of Drug Delivery System Based on Nanozyme Cascade Technology in Chronic Wound

Biomedical applications of stimuli‐responsive nanomaterials

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Enzyme-triggered on-demand release of a H2O2-self-supplying CuO2@Fe3O4 nanoagent for enhanced chemodyamic antimicrobial therapy and wound healing

Abstract: Nanoagents for chemodynamic therapy (CDT) hold a promising future in the field of antimicrobials, especially copper peroxide (CuO2) (CP) nanomaterials which have garnered significant attention due to their ability to...

Cited by 8 publications

References 53 publications

Advances in H2O2-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Advances in H2O2-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Application of Drug Delivery System Based on Nanozyme Cascade Technology in Chronic Wound

Biomedical applications of stimuli‐responsive nanomaterials

Contact Info

Product

Resources

About

Enzyme-triggered on-demand release of a H₂O₂-self-supplying CuO₂@Fe₃O₄ nanoagent for enhanced chemodyamic antimicrobial therapy and wound healing

Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications