1991
DOI: 10.1016/0003-9861(91)90098-4
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Enzymological evidence for the indispensability of small intestine in the synthesis of arginine from glutamate

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Cited by 43 publications
(39 citation statements)
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“…Since the plasma citrulline level is highly dependent on the small bowel epithelial cell mass, 36 loss of small intestinal enterocytes will decrease plasma citrulline levels. Citrulline values were compared in four groups of animals, receiving either syngeneic or allogeneic BM and splenocytes, combined with either PBS or KGF treatment.…”
Section: Kgf Decreases Injury To the Gastrointestinal Tractmentioning
confidence: 99%
“…Since the plasma citrulline level is highly dependent on the small bowel epithelial cell mass, 36 loss of small intestinal enterocytes will decrease plasma citrulline levels. Citrulline values were compared in four groups of animals, receiving either syngeneic or allogeneic BM and splenocytes, combined with either PBS or KGF treatment.…”
Section: Kgf Decreases Injury To the Gastrointestinal Tractmentioning
confidence: 99%
“…It is an excitatory neurotransmitter in the central nervous system of mammals (Watkins and Evans 1981) and functions as both substrate and product in many distinct reactions. It serves as a precursor molecule for the synthesis of various metabolites including N-acetyl-L-glutamate, δ-1-Pyrroline-5-carboxylate, β-citrylglutamate, L-γ-glutamyl-L-cysteine (Sonoda and Tatibana 1983;Wakabayashi et al 1991b;Collard et al 2010;Tu and Anders 1998;Battaglioli et al 2003). Glutamate is synthesized from glutamine, α-ketoglutarate and 5-oxoproline (Hu et al 2010;Cho et al 2001;Chen et al 1998).…”
Section: Introductionmentioning
confidence: 99%
“…Experimental and clinical data suggest a non-homogenous distribution of citrulline production. The distribution of P5CS activity in rats was 26%, 31%, 33% and 10% in the duodenum, upper jejunum, lower jejunum and ileum, respectively [120] . The release of citrulline measured as venous minus arterial concentration in patients admitted for elective gastrointestinal surgery was 30.4 ± 4.0 μmol/L and 8.4 ± 1.7 μmol/L for the jejunum and ileum, respectively [111] .…”
Section: Source Of Circulating Citrullinementioning
confidence: 88%
“…P5CS is unique to small intestinal enterocytes [116,[119][120][121] . PDG converts glutamine to glutamate and ammonia.…”
Section: Pathways For Citrulline Synthesismentioning
confidence: 99%
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