Enzymosomes: A Rising Effectual Tool for Targeted Drug Delivery System

Abstract

The study aims to develop enzymosomes as an emerging novel drug delivery system for site-specific action. Enzymosomes utilises the specific nature of an enzyme, which is binding to a specific substrate at a controlled rate and catalysing product production step. An enzyme is encapsulated by coupling covalently to the surface of liposomes/lipid vesicles to form enzymosomes. Enzymes links through acylation, direct conjugation, physical adsorption, encapsulation methods to prepare enzymosomes with targeted action. Such novel drug delivery systems prove effective drug release and concomitantly reduces undesirable side effects of conventional treatment methods and hence showcase improvement in the long-term therapy of the disease. They are a promising substitute to conventional treatment therapies of gout, antiplatelet activities etc. Enzymosomes are newly designed supramolecular vesicular delivery systems to be useful as a tool in pharmaceutics for the raising of drug targeting and physicochemical properties and hence bioavailability. It shows beneficial effects of drugs with a narrow precision because targeting of these drugs to their site of action improves the drugs overall pharmacodynamics and pharmacokinetic profile. It also minimizes alterations in the normal enzymatic activity, thus enhancing half-life and achieve enzyme activity on targeted sites such as cancerous cells.

Stimuli-Responsive Polymeric Nanosystem for Colon Specific Drug Delivery

“…99 In Crohn's disease, there is an increase in mucus production thus paving way of attachment of nanoparticles to thick mucus layer more strongly and leads to detention of drug to diseased colitis tissue. 100 A supportive base for muco-adhesive nanodrug delivery system was suggested by Niebel et al who found that clodronate alone was ineffective in colitis therapy but proved efficient when it was combined with cationic nanoparticle polymethacrylate. 101 Colon drug targeting using liposomes The use of liposomes as carriers has improved drug delivery to colon.…”