Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units

Abstract

Introduction Eosinopenia is a cheap and forgotten marker of acute infection that has not been evaluated previously in intensive care units (ICUs). The aim of the present study was to test the value of eosinopenia in the diagnosis of sepsis in patients admitted to ICUs.

Interleukin 5 Is Protective during Sepsis in an Eosinophil-Independent Manner

“…One study found that sepsis survivors had a trend toward elevated levels of IL-5 compared with nonsurvivors (23). However, sepsis and bacterial infections are associated with a marked eosinopenia (24,25). This apparent paradox suggests differential and independent functions for eosinophils and IL-5 in sepsis.…”

Comparison of the Eosinophil Count to C –reactive protein, Leukocyte Count, and Neutrophil Count for the detection of bacterial infection in ill-appearing children with fever admitted to the Emergency Department

“…In a prospective study, eosinopenia (<40 cells/mm 3 ) was a good diagnostic tool for distinguishing between non-infection and infection in the intensive care unit (ICU), while it was a moderate marker for discriminating between systemic inflammatory response syndrome and infection in newly admitted critically ill patients. (8) In that study, the AUROC was 0.89 for eosinophils and 0.77 for CRP for discriminating between non-infection and infection. Shaaban et al (14) found that the AUROC for eosinopenia (<50 cells/mm 3 ), high CRP (>70 mg/L), and high procalcitonin (>1.5 μg/L) for discriminating between non-infection and infection in the adult critical care unit were 0.72, 0.92, and 0.89, respectively.…”

“…(5-7) Furthermore, procalcitonin testing is very expensive and is seldom available in emergency departments in developing countries such as Turkey. (8) In 1893, Zappert (9) first described marked reduction in the number of circulating eosinophils in acute infection, and it was utilized as a useful diagnostic sign during the first quarter of the last century. (10) After observing that eosinopenia is part of the normal response to stress, (11) it was assumed that the eosinopenia of acute infection is a secondary response to stress caused by the infection.…”

“…(12) Since the early 2000s, eosinopenia has once again become a popular marker, although most studies have examined adult patients. (8,(13)(14)(15) It is not clear whether eosinopenia is a useful infection biomarker in children.…”

Hyperimmunoglobulin E Syndrome-like Symptoms in a Hemodialysis Patient who Developed Multiple Subcutaneous<i>Staphylococcus aureus</i> Abscesses

“…A STAT3 gene analysis was required to precisely differentiate HIES in this case because some cases of HIES in patients without characteristic facies or bone and connective tissue abnormalities have been reported. In addition, eosinopenia has recently been reported to be a marker of sepsis (9), leading us to suspect that the current patient's low eosinophil count on admission may have been caused by a sepsis-like condition.…”