Eosinophil cationic protein (ECP) level and its correlation with eosinophil number or IgE level of peripheral blood in patients with various skin diseases

Kim, Taeyoon; Park, Hong-Jin; Kim, Chung-Won

doi:10.1016/s0923-1811(97)00614-2

Cited by 31 publications

(24 citation statements)

References 18 publications

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“…We also foimd that patients with CU with uncontrolled disease or with MetS have higher serum levels of ECP and fi-equently produce negative ASST results. Clinical manifestations including angioedema and cold and dermographic urticaria have been reported to be positively associated with serum ECP levels in patients with CU (24). In the present study, the ECP level did not vary according to the presence of angioedema, although it was significantly correlated with waist circumference and serum levels of C3 and total IgE.…”

Section: Discussioncontrasting

confidence: 52%

Co-existence of Chronic Urticaria and Metabolic Syndrome: Clinical Implications

Ye¹,

Jin²,

Hwang³

et al. 2013

Acta Derm Venerol

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A systemic pro-inflammatory and pro-coagulating state occurs in subjects who have both chronic urticaria and metabolic syndrome. To investigate the prevalence and clinical impact of metabolic syndrome in Korean patients with chronic urticaria, a hospital-based cross-sectional study of 131 patients was performed. Metabolic syndrome was assessed by the criteria of the National Cholesterol Education Program's Adult Treatment Panel III. Urticaria disease activity was assessed by total urticaria activity score (range 0-15). Thirty-nine patients (29.8%) had metabolic syndrome compared to 17.8% in a matched control group (p=0.001). Patients with chronic urticaria and metabolic syndrome were older, had a higher mean urticaria activity score and serum levels of eosinophil cationic protein, tumour necrosis factor-α, and complements, and showed a higher rate of negative autologous serum skin tests compared with those with-out metabolic syndrome. Logistic regression analysis indicated that an urticaria activity score of ≥ 13 (p=0.025) and the presence of metabolic syndrome (p=0.036) were independent predictors of uncontrolled chronic urticaria. We conclude that patients with severe and uncontrolled chronic urticaria should be evaluated for metabolic syndrome in order to reduce cardiovascular risk and improve chronic urticaria outcomes.

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Section: Discussioncontrasting

confidence: 52%

Co-existence of Chronic Urticaria and Metabolic Syndrome: Clinical Implications

Ye¹,

Jin²,

Hwang³

et al. 2013

Acta Derm Venerol

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“…Serum ECP has been decribed as a marker of disease activity in AD 4 and in asthma 23 . It has also been found to be elevated in non‐atopic diseases such as psoriasis and physical urticaria 24 . However, it is still controversial whether ECP is a useful severity marker in AD as there are also studies that have not been able to demonstrate a correlation between ECP and skin status 8,9 .…”

Section: Discussionmentioning

confidence: 99%

Comparison of different activity parameters in atopic dermatitis: correlation with clinical scores

et al. 2002

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“…Moreover, in a study by Nishimoto et al ., peripheral eosinophil counts were found to be more sensitive than serum ECP levels related to the improvement of atopic dermatitis 22 . In addition, serum ECP levels and eosinophil numbers in peripheral blood were found to be correlated also in patients with psoriasis 6 . In light of these findings, we considered that, peripheral blood eosinophil counts might provide enough data on the participation of these cells to the pathogenesis of psoriasis.…”

Section: Discussionmentioning

confidence: 90%

“…Although there is increasing evidence, it is not clearly elucidated yet, whether eosinophils participate in the pathogenesis of psoriasis or not. In a study aimed to evaluate the serum eosinophil cationic protein (ECP) levels in various skin diseases, ECP levels were found to be significantly higher in patients with DE, acute urticaria and psoriasis than in healthy controls 6 . On the other hand, in the study by Juhlin and Venge, serum ECP levels were elevated in half of the patients with progressive plaque psoriasis, whereas the number of the circulating eosinophils was normal 7…”

Section: Discussionmentioning

confidence: 99%