Eosinophil cationic protein, specific IgE and IgG4 in human toxocariasis

Magnaval, Jean-François; Faufingue, J.-H.; Morassin, B.; Fabre, Richard

doi:10.1017/joh2006369

Cited by 26 publications

(18 citation statements)

References 39 publications

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“…Distinct mechanisms may be responsible for the diverse parasites. For example, the production of specific IgE against parasites has been shown for Toxocara [21] or Anisakis simplex [22]. Although some studies or case reports indicated high total IgE and/or parasite-specific IgE values in chronic urticaria patients infected with Giardia [23] or B. hominis [24], other studies reported no difference in total IgE levels between patients who had the same parasites and healthy controls [18].…”

Section: Discussionmentioning

confidence: 99%

Parasitic Infections in Children with Chronic Spontaneous Urticaria

Yılmaz

Karaatmaca²,

Saçkesen³

et al. 2016

Int Arch Allergy Immunol

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Background: Parasites have been proposed to be an underlying cause of chronic spontaneous urticaria (CSU) in childhood, but a clear causal relationship between them has not been established. This study aimed to investigate the prevalence of parasitic infection-related CSU (PIRCSU) in children and to determine the factors associated with PIRCSU. Method: Data from 211 children with CSU were analyzed. Information on stool examination, antiparasitic medications received, and response to treatment was recorded. The disappearance of urticaria for more than 6 months is defined as remission, and remission of urticaria after antiparasitic treatment is defined as PIRCSU. Results: Parasites were detected in 21 (10%) patients. Blastocystis hominis was the most common parasite. After antiparasitic medication, all samples became normal; urticaria continued in 5, was reduced in 6, and disappeared in 10 patients. The latter 10 patients were considered as cases of PIRCSU (4.7%). The erythrocyte sedimentation rate was significantly higher in patients with PIRCSU than in those without [8.5 mm/h (3.5-14.5) vs. 2 (0-7), p = 0.011]. Gastrointestinal complaints were significantly more frequent in patients with PIRCSU than in those without. The occurrence of abdominal pain was a significant risk factor that increased the probability of PIRCSU [OR = 6.60, 95% CI = 1.35-32.23, p = 0.020]. Conclusion: Parasites may cause CSU even in nontropical countries, and remission may only be possible with the treatment of the parasitic infection. The occurrence of abdominal pain points to parasitic infection in patients with CSU. Therefore, we suggest that parasites should be investigated routinely, especially if the patient has gastrointestinal symptoms of CSU in childhood.

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Section: Discussionmentioning

confidence: 99%

Parasitic Infections in Children with Chronic Spontaneous Urticaria

Yılmaz

Karaatmaca²,

Saçkesen³

et al. 2016

Int Arch Allergy Immunol

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“…Büyürken oluşturdukları karaciğer hasarına bağlı olarak, fonksiyonlarında bozulma meydana gelebileceği bilinmektedir. Yapılan çalışmalarda, KE'li hastalarda ALT ve AST düzeylerinin arttığı gösterilmiş, karaciğer enzim yüksekliği-nin dokuda meydana gelen lokal eozinofi li ile ilişkili olabileceği bildirilmiştir [27][28][29] . Bizim çalışmamızda, tanı sırasında biyokimya parametreleri içinde GGT yüksekliği (%28) belirgin olup bunu ALT (%16), AST (%16) ve ALP (%13) yüksekliği takip etmiştir.…”

Section: şEkil 4 Seropozitif Ke öN Tanılı (N= 32) Ve Seronegatif Anunclassified

Evaluation of the Radiological, Biochemical and Serological Parameters of Patients Prediagnosed as Cystic Echinococcosis in Çorum, Turkey

As¹,

Özcan²,

L³

et al. 2015

Mikrobiyol Bul

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“…Reflecting on these findings, it could be mentioned that urticaria is a skin manifestation, related to helminths or arthropods with a cutaneous phase: Schistosoma, Sarcoptes scabiei, as well as ticks and other blood sucking arthropods have been involved in Th2-based immunologic mechanisms [37,38]. Among patients with toxocariasis, an elevated eosinophil cationic protein (ECP) level was significantly associated with both cough and rhinitis, a high level of specific anti-toxocara IgE with itchy rashes [39]. Loeffler's syndrome, which resembles the pathophysiological features of chronic asthma with its Th2-related immunologic feature, is related to Ascaris and Necator infection, both of which have an obligatory pulmonary phase [40].…”

Section: Host-parasite Interaction and Parasito-sis-urticaria Relatiomentioning

confidence: 99%

Urticaria as Symptom of Parasite Migration Through the Biological Barriers

Bakiri¹

2011

TOALLJ

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Abstract:The absence of a consistent link between parasitoses and urticarial symptoms in the clinical investigations contrasts to the fact that some parasites are the most potent inducers of immunoglobulin E that exist in nature. To shed some light into this question, this review is focused on the actual knowledge regarding parasites life cycle, interactions with host immunity, the influence on host behavior, and finally the role of all these factors on the urticaria development. The collected data demonstrate that parasites could manipulate the host behavior for its own benefit in different ways, inducing urticarial reactions during penetration into different biological barriers. In this context, urticaria may be associated with certain stages of the parasites' life cycle or with host tissue location, but not necessarily only with their presence in the host organism. As compared to T helper (Th) 1, the Th2 response, the eosinophilic infiltration and the complement inhibition could assure a more pleasant surrounding area for the development of some parasites. Taken together, these concepts could explain the epidemiological discrepancy between low rates of urticaria occurrence, and the usual parasites-induced Th2 response. However, further studies are necessary to provide better-based conclusions.

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Eosinophil cationic protein, specific IgE and IgG4 in human toxocariasis

Cited by 26 publications

References 39 publications

Parasitic Infections in Children with Chronic Spontaneous Urticaria

Parasitic Infections in Children with Chronic Spontaneous Urticaria

Evaluation of the Radiological, Biochemical and Serological Parameters of Patients Prediagnosed as Cystic Echinococcosis in Çorum, Turkey

Urticaria as Symptom of Parasite Migration Through the Biological Barriers

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