Eosinophil Density in Common Benign and Malignant Salivary Gland Tumors with Congo Red Staining

Seifi, Safoura; Azizi, Zahra; Ghanghermeh, Alten; Eftekharian, Shahriar; Salehinejad, Jahanshah; Gholinia, Hemmat

doi:10.4103/ijmpo.ijmpo_217_17

Cited by 2 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, it is now widely recognized that CD56 lacks specificity as a standalone neuroendocrine marker 19–21 . Even among salivary gland neoplasms, pleomorphic adenoma, and adenoid cystic carcinoma have been shown to express CD56 22 . More specific neuroendocrine markers such as INSM1, synaptophysin, and chromogranin were negative in all cases tested in this study.…”

Section: Discussionmentioning

confidence: 54%

Palisading Adenocarcinoma

Bishop

Weinreb²,

Vliet

et al. 2023

American Journal of Surgical Pathology

View full text Add to dashboard Cite

Adenocarcinoma, not otherwise specified (NOS) is a heterogenous group of salivary gland tumors that likely contains distinct tumors that have not yet been characterized. Indeed, in recent years, cases previously diagnosed as adenocarcinoma, NOS have been recategorized into novel tumor designations such as secretory carcinoma, microsecretory adenocarcinoma, and sclerosing microcystic adenocarcinoma. We sought to describe a distinctive, hitherto-undescribed salivary gland tumor encountered in the authors’ practices. Cases were pulled from the surgical pathology archives of the authors’ institutions. Histologic, immunohistochemical, and clinical findings were tabulated, and targeted next-generation sequencing was performed on all cases. Nine cases were identified, arising in 8 women and 1 man ranging from 45 to 74 years (mean, 56.7 y). Seven tumors (78%) arose in the sublingual gland, while 2 (22%) arose in the submandibular gland. The cases shared a distinctive morphologic appearance. They were biphasic, with ducts scattered among a predominant polygonal cell with round nuclei, prominent nucleoli, and pale eosinophilic cytoplasm. These cells were arranged as trabeculae and palisaded as pseudorosettes around hyalinized stroma and vessels, resembling a neuroendocrine tumor. Four of the cases were well-circumscribed, while the remaining 5 showed infiltrative growth including perineural invasion in 2 (22%) and lymphovascular invasion in 1 (11%). Mitotic rates were low (mean, 2.2/10 HPFs); necrosis was absent. By immunohistochemistry, the predominant cell type was strongly positive for CD56 (9 of 9) and variably positive for pan-cytokeratin (AE1/AE3) (7 of 9) with patchy S100 (4 of 9), but negative for synaptophysin (0 of 9) and chromogranin (0 of 9), while the ducts were strongly positive for pan-cytokeratin (AE1/AE3) (9 of 9) and CK5/6 (7 of 7). Next-generation sequencing did not reveal any fusions or obvious driver mutations. All cases were resected surgically, with external beam radiation also done in 1 case. Follow-up was available in 8 cases; there were no metastases or recurrences after 4 to 160 months (mean, 53.1 mo). A dual population of scattered ducts with a predominance of CD56-positive neuroendocrine-like cells characterizes a unique salivary gland tumor which is often encountered in the sublingual glands of women, for which we propose the term “palisading adenocarcinoma.” Although the tumor was biphasic and had a neuroendocrine-like appearance, it lacked convincing immunohistochemical evidence of myoepithelial or neuroendocrine differentiation. Although a subset showed unequivocally invasive growth, this tumor appears to behave in an indolent manner. Moving forward, recognition of palisading adenocarcinoma and its separation from other salivary adenocarcinomas, NOS will facilitate a better understanding of the characteristics of this previously unrecognized tumor.

show abstract

Section: Discussionmentioning

confidence: 54%

Palisading Adenocarcinoma

Bishop

Weinreb²,

Vliet

et al. 2023

American Journal of Surgical Pathology

View full text Add to dashboard Cite

show abstract

“…Additionally, NK cells, as an essential component of innate immunity, can directly kill cancer cells even in the absence of HLA presentation, and one ACC study validated the increase in CD56 + NK cell levels in tumor tissues. 29 However, the use of clinical NK therapy for ACC has not yet been reported. These mechanisms remain unclear.…”

Section: Introductionmentioning

confidence: 99%

“…The MYB‐NFIB fusion peptide produces neoantigens that can be recognized by T cells 28 and has been proposed as a breakthrough target for immunotherapy. Additionally, NK cells, as an essential component of innate immunity, can directly kill cancer cells even in the absence of HLA presentation, and one ACC study validated the increase in CD56 + NK cell levels in tumor tissues 29 . However, the use of clinical NK therapy for ACC has not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

NKT cells contribute to alleviating lung metastasis in adenoid cystic carcinoma

et al. 2023

View full text Add to dashboard Cite

Salivary adenoid cystic carcinoma (SACC) with a unique MYB‐NFIB fusion has been considered an “immune‐cold” tumor, but the mechanisms behind this remain unclear. In this study, we analyzed the immune status of 29 SACC patients and found that most lung metastases exhibited an immunoinflammatory state, in contrast to the primary SACC tissues. Single‐cell sequencing data showed that anergic T‐cell types were low in primary inflammatory tissues, while inflammatory metastatic lung tissues had elevated levels of anergic CD8+ natural killer T (NKT)‐like cells and low levels of memory T cells. Primary exclusive tissues had high levels of myeloid‐derived suppressor cells (MDSCs) and low levels of activated CD8+ NKT‐like cells. These data support the fact that metastatic SACC cells might induce a stronger immune response in the lung. Additionally, an in vivo experiment showed that a minimally invasive SACC cell line with higher expression of human leukocyte antigens ‐B and ‐C induced NKT cell activation in mice and effectively attenuated the incidence of lung metastases caused by a highly invasive SACC cell line. This suggests that NKT therapy may be active in treating SACC lung metastasis. Conclusively, this study sheds light on the immune microenvironment of SACC and highlights the potential of NKT‐based therapy.

show abstract

Eosinophil Density in Common Benign and Malignant Salivary Gland Tumors with Congo Red Staining

Cited by 2 publications

References 18 publications

Palisading Adenocarcinoma

Palisading Adenocarcinoma

NKT cells contribute to alleviating lung metastasis in adenoid cystic carcinoma

Contact Info

Product

Resources

About