2015
DOI: 10.1177/2040622315609251
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Eosinophilic airway inflammation: role in asthma and chronic obstructive pulmonary disease

Abstract: Abstract:The chronic lung diseases, asthma and chronic obstructive pulmonary disease (COPD), are common affecting over 500 million people worldwide and causing substantial morbidity and mortality. Asthma is typically associated with Th2-mediated eosinophilic airway inflammation, in contrast to neutrophilic inflammation observed commonly in COPD. However, there is increasing evidence that the eosinophil might play an important role in 10-40% of patients with COPD. Consistently in both asthma and COPD a sputum e… Show more

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Cited by 270 publications
(209 citation statements)
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References 142 publications
(171 reference statements)
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“…Of special importance with respect to the current findings, is that both type VI collagen formation (Pro-C6) and degradation (C6M) were correlated to eosinophil blood count. This is an interesting finding as in both asthma and COPD, sputum eosinophilia is associated with response to therapy and has been used for tailored strategies for normalization of sputum eosinophils in order to reduce exacerbation frequency and severity [72]. This may reflect a disruption of the integrity between the interstitial matrix and basement membrane, and inflammation by eosinophils and neutrophils, resulting in the destruction of type VI collagen and a repair response associated with more type VI collagen formation.…”
Section: Discussionmentioning
confidence: 99%
“…Of special importance with respect to the current findings, is that both type VI collagen formation (Pro-C6) and degradation (C6M) were correlated to eosinophil blood count. This is an interesting finding as in both asthma and COPD, sputum eosinophilia is associated with response to therapy and has been used for tailored strategies for normalization of sputum eosinophils in order to reduce exacerbation frequency and severity [72]. This may reflect a disruption of the integrity between the interstitial matrix and basement membrane, and inflammation by eosinophils and neutrophils, resulting in the destruction of type VI collagen and a repair response associated with more type VI collagen formation.…”
Section: Discussionmentioning
confidence: 99%
“…The importance of eosinophils in asthma has been known for decades, and assessment of sputum eosinophil content has significant utility in treatment choice for asthmatic patients (150). Eosinophils have both inflammatory and tissue remodeling effects, and their derived mediators can damage epithelial cells, stimulate EMT, activate or suppress sensory nerves, modulate the activity of stem cells and plasma cells, and alter mechanical responses of airways (151153). Tan and colleagues (154) took biopsies from the superior meatus, where the olfactory zone resides, and found a strong correlation between eosinophils in that area and anosmia.…”
Section: Race Eosinophilia and Crs: What Are The Roles Of Genes Andmentioning
confidence: 99%
“…In COPD, there is infiltration of neutrophils and macrophages driven by T h 1, T h 17, and CD8 + T cells, and typically no mast-cell activation, which accounts for the lack of reversibility. Nevertheless, eosinophil might play an important role in 10%–40% of patients with COPD 11. Furthermore, patients with severe asthma may have prominent neutrophilia in biopsy specimens, although these patients are steroid-dependent and demonstrate more severe disease when compared to patients in whom bronchoalveolar lavage eosinophilia is evident 12…”
Section: How To Differentiate Asthma From Copdmentioning
confidence: 99%