Eosinophilic Fasciitis

Boiesen, Mads; Keiding, Lis; Thomsen, Kristian

doi:10.1159/000249768

Cited by 5 publications

(1 citation statement)

References 3 publications

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“…One of our patients developed aplastic anemia and Hashimoto thyroiditis during the disease process. Thyroid abnormalities, such as Hashimoto disease and Graves disease are rarely reported in association with EF [25, 26,52,53,54]. …”

Section: Discussionmentioning

confidence: 99%

Eosinophilic Fasciitis 30 Years after – What Do We Really Know?

Antic¹,

2006

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Background: Eosinophilic fasciitis (EF) is a rare fibrosing disorder associated with peripheral eosinophilia and scleroderma-like induration of the distal extremities which affects substantially quality of life. Although the disease has been described 30 years ago, the etiology and pathomechanisms are still obscure, and consensus for therapy is lacking. Numerous case reports of patients with EF exist but series are scarce. Patients and Methods: Eleven patients with EF from the Department of Dermatology, Kantonsspital Aarau, the University Hospital Basel and the Outpatient Clinic of Dermatology, Triemli Hospital Zurich, Switzerland, were retrospectively studied. Results: In 4 patients the initial diagnosis was not recognized by the referring nondermatologists. The median age was 55 years, excluding the youngest patient ever diagnosed with EF (age = 1 year). All patients showed an induration of the skin, which led to painful contractures in the joints in 3 cases. All but 2 patients demonstrated edema. A slight predominance of the upper extremities was observed. Sclerodactyly was noticed in 1 patient. Three patients reported an initial trauma at the affected site. Two patients were tested positive for borreliosis. One patient subsequently developed aplastic anemia and Hashimoto thyroiditis. Visceral or extracutaneous involvement was absent. Eight patients had a full or partial recovery under corticosteroids whereas in 2, improvement could be achieved only with cyclosporine, azathioprine or cyclophosphamide. Conclusions: The diagnosis of EF can be established by clinical, laboratory and histological findings. In general, corticosteroids are highly efficacious in EF and only a minority of patients need other immunosuppressive or cytostatic drugs.

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Section: Discussionmentioning

confidence: 99%

Eosinophilic Fasciitis 30 Years after – What Do We Really Know?

Antic¹,

2006

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Miscellaneous Rheumatic Syndromes

Katsumoto

Mariette

2021

Rheumatic Diseases and Syndromes Induced by Cancer Immunotherapy

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Eosinophilic fasciitis associated with autoimmune phenomena after bone marrow transplantation: report of two cases

et al. 2005

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Between January 1992 and May 2004, 189 patients underwent allogeneic bone marrow transplantation (BMT) for haematological malignancies from HLA-identical sibling donors in our transplantation unit. Of the 189 patients, 2 developed eosinophilic fasciitis (EF). The first patient developed Hashimoto's thyroiditis and EF 11 and 21 months after BMT, respectively. In the second patient EF occurred 9 months after BMT, accompanied by antinuclear antibodies, antiextractable nuclear antigens and antigliadin antibodies. Both patients were treated with extracorporeal photochemotherapy (ECP), resulting in improvement of fasciitis in both and normalization of antithyroid antibodies in the first patient. Our data confirm the rarity of fasciitis after BMT and the efficacy of ECP, recently applied experimentally in one patient for the treatment of fasciitis after BMT. Moreover, we report for the first time the association of fasciitis with autoimmune phenomena after BMT. The correlation between the two entities is supported by remission of Hashimoto's thyroiditis after ECP treatment for fasciitis.

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Eosinophilic Fasciitis

Cited by 5 publications

References 3 publications

Eosinophilic Fasciitis 30 Years after – What Do We Really Know?

Eosinophilic Fasciitis 30 Years after – What Do We Really Know?

Miscellaneous Rheumatic Syndromes

Eosinophilic fasciitis associated with autoimmune phenomena after bone marrow transplantation: report of two cases

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