Eosinophilic gastroenteritis.

Abstract

sis. The dramatic variation in values of creatine kinase activities in case 2 was unexplained. It was not obviously related to varying degrees of exertion before testing. This phenomenon has been described previously and could lead to diagnostic confusion. The condition is generally regarded as inherited on an autosomal recessive basis, but there is evidence to suggest genetic heterogeneity.These three patients' symptoms, dating from much earlier in childhood, confirm that type V glycogen storage disease may be diagnosed at an earlier age than often reported. In all three symptoms were related to a disinclination to walk up hills. No more specific symptoms than this occurred within the histories. The test for ischaemic lactate concentration is an important and fairly straightforward procedure that should be considered in a child presenting with any of the features detailed in this report. An earlier diagnosis may be particularly important if the recent preliminary report of improvement in symptoms related to a high protein diet is confirmed in other patients.7

Causes of eosinophilic ascites – A systematic review

“…In 19 cases, although multiple biopsies were performed, their results revealed normal mucosa. Because of negative biopsy results in the absence of pathological features at abdominal echo, CT scans or endoscopy, in 6 subjects [17][18][50][51][52][53] laparoscopy with peritoneal biopsies provided valuable information to achieve a definite diagnosis. In 3 patients surgery was not performed, and the diagnosis was established according to clinical and biological criteria [33,[54][55].…”

“…Surgery [27,37], ketotifen [82], azathioprine [16], sodium chromoglycate and montelukast [7,66] as monotherapy or in combination with corticosteroids were successfully used while treating relapses. Six patients required long-term steroid therapy [29,40,53,[83][84][85].…”

Eosinophilic Gastroenteritis

“…Firstly it has been suggested that it represents an allergic gastrointestinal response to a variety of allergens -a concept supported by a family and personal history of allergic disorders such as asthma, hayfever and hypersensitivity to drugs in 50-70% of patients (7 ,8). Several cases have been described where gastrointestinal symptoms have been exacerbated by a specific food challenge and responded to elimination diets (1,9). The concept of food allergy is by no means universally accepted however.…”

Joint ESPGHAN/NASPGHAN Guidelines on Childhood Eosinophilic Gastrointestinal Disorders Beyond Eosinophilic Esophagitis

“…The majority of patients with EoN have elevated peripheral blood eosinophil counts, and even total white blood cell counts (43,(54)(55)(56)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66)(67)(68). In EoC, peripheral eosinophilia may occur in a proportion of patients (13,20), as well as iron deficiency anemia and hypoalbuminemia (20).…”