Eosinophilic leukaemia with trisomy 8 and double gammopathy.

Ribeiro, Inês; Carvalho, Isabel; Fontés, Michel; Lima, Francisco de Assis Silva; Matos, Ricardo; Anderson, Brian A.; Uva, Luís

doi:10.1136/jcp.46.7.672

Cited by 10 publications

(4 citation statements)

References 5 publications

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“…It has been speculated that the erb B oncogene, localized to 7p12.3-p12.1, is amplified as a result of this translocation, but, its association with the pathogenesis of MDS is controversial [16, 17]. In our case, trisomy 8 was also involved, which has been observed not only in conjunction with MDS-Eo [2, 12, 13], but also with CEL [18, 19]or idiopathic hypereosinophilic syndrome [20, 21]. In MDS-Eo, trisomy 8 has been reported in 5 cases, including the present case [2, 11, 12, 22].…”

Section: Discussionmentioning

confidence: 69%

Myelodysplastic Syndrome with Clonal Eosinophilia Accompanied by Eosinophilic Pulmonary Interstitial Infiltration

et al. 2000

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We report a case of de novo myelodysplastic syndrome with clonal eosinophilia (MDS-Eo) and eosinophilic pulmonary interstitial infiltration, confirmed by autopsy. Cytogenetic study using Giemsa banding identified 47,XY,+1,der(1;7)(q10;p10),+8 in the marrow cells. Simple Giemsa staining revealed the same chromosomal aberration in metaphase spreads with eosinophilic granules, indicating the clonal proliferation of eosinophils. To our knowledge, our case is the 6th reported case of MDS-Eo with cytogenetically confirmed clonal eosinophilia, and the first autopsy of MDS-Eo. A review of the literature combined with our findings suggests that this type of chromosomal aberration might be involved in the as yet unknown pathogenesis of MDS-Eo.

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Section: Discussionmentioning

confidence: 69%

Myelodysplastic Syndrome with Clonal Eosinophilia Accompanied by Eosinophilic Pulmonary Interstitial Infiltration

et al. 2000

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“…Following the initial report, numerous case reports or small series of patients with eosinophilic leukaemia have been reported (Saito et al, 1985;Kueck et al, 1991;Weinfeld et al, 1977;Ribeiro et al, 1993), although until today no report has shown conclusively that the eosinophils are monoclonal (Fauci et al, 1982). Chromosome abnormalities have been reported in most cases of eosinophilic leukaemia including trisomies of chromosomes 8, 10 or 21 (Saito et al, 1985;Goldman et al, 1975;Kueck et al, 1991;Weinfeld et al, 1977;Ribeiro et al, 1993). Additional translocations such as the t(2;5) (p23;q35) have been reported (Sato et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

“…Also in a case with refractory anaemia, markedly increased eosinophils were found, but the aberrant karyotype was not found in the eosinophils (Perez-Losada et al, 1994). In HES, several patients with different chromosome abnormalities have been decribed, which suggests a malignant monoclonal myeloproliferative disorder in these cases (Malbrain et al, 1996;Broustet et al, 1986;Mori et al, 1986;Fischkoff et al, 1988;Yoo et al, 1988;Needleman et al, 1990;Ribeiro et al, 1993;Sato et al, 1994). However, these cases lacked direct evidence that the eosinophils were part of the malignant clone.…”

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confidence: 99%

Chronic eosinophilic leukaemia (CEL): a distinct myeloproliferative disease

Weide¹,

Rieder

Mehraein

et al. 1997

Br J Haematol

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Chronic eosinophilic leukaemia has not yet been clearly defined, mainly due to the fact that it has not been conclusively shown as a monoclonal disease which should be separated from chronic myelogenous leukaemia, acute myelogenous leukaemia with eosinophilia (AML, FAB M4Eo), and the idiopathic hypereosinophilic syndrome. We report a patient with a white blood cell count of 17.6 × 109/l with 74% eosinophils, normal platelet count and haemoglobin. No blasts were seen in the peripheral blood and the percentage of blasts in the bone marrow was <3%. A diagnosis of chronic eosinophilic leukaemia was made. Chromosome analysis of a bone marrow aspirate disclosed a trisomy 15 together with loss of the Y chromosome. Moreover, FISH analysis on May‐Grünwald‐Giemsa‐stained peripheral blood smears demonstrated trisomy 15 in the eosinophils. 3 months after initial diagnosis the patient went into blast crisis and died. The blast cells exhibited trisomy 15 and loss of the Y chromosome in a complex, aberrant karyotype. In conclusion, the case shows that chronic eosinophilic leukaemia is a monoclonal, myeloproliferative disease with eosinophils as part of the malignant clone. Clinically, chronic eosinophilic leukaemia can be separated into a chronic phase and a blast crisis.

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“…We believe, on the basis of our own experience and of reports from the literature (Liesveld & Abboud, 1991;Malbrain et al, 1994;Zabel & Schlaak, 1991) that in those selected patients CSA can have a role, because it acts to suppress the activation of T lymphocytes and to decrease the output of regulatory cytokines that stimulate eosinophil production from these lymphocytes (Liesveld & Abboud, 1991). Table III lists the chromosomal abnormalities that have been previously reported in association with HES or eosinophilic leukaemia (Baumgarten et al, 1989;Bitran et al, 1977;Broustet et al, 1986;Cabrol, 1979;Chan et al, 1994;Da Silva et al, 1988;Ellman et al, 1979;Fischkoff et al, 1988;Goffman et al, 1983;Goh et al, 1985;Goldman et al, 1975;Guitard et al, 1994;Huang et al, 1979;Humphrey et al, 1981;Kaneko et al, 1983;Keene et al, 1987;Lönnqvist et al, 1979;Maeda et al, 1985;Michel et al, 1991;Mitelman et al, 1975;Needleman et al, 1990;Parreira et al, 1986;Ribeiro et al, 1993;Stockdill et al, 1980;Tono-oka et al, 1984;Weinfeld et al, 1977;Wolz et al, 1993;Yoo et al, 1984). Trisomy 8 is a common finding in myeloid haematological malignancies and has been reported in association with eosinophilic leukaemia or HES in six cases (Bitran et al, 1977;Goh et al, 1985;…”

Section: Discussionmentioning

confidence: 99%

Further evidence for the clonal nature of the idiopathic hypereosinophilic syndrome: complete haematological and cytogenetic remission induced by interferon‐alpha in a case with a unique chromosomal abnormality

Malbrain¹,

Bergh

Zachée³

1996

Br J Haematol

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A 49-year-old man with the idiopathic hypereosinophilic syndrome (HES) and a unique chromosomal abnormality 46,XY,t(5;9)(q32;q33) is reported. Complete cytogenetic remission was induced by interferon alpha-2b (IFN-alpha). The beneficial action of IFN-alpha in different stem-cell disorders such as CML, HES, multiple myeloma and solid tumours such as hypernephroma or malignant melanoma suggests a common regulatory effect possibly by immunomodulation or other (immune-mediated) mechanisms, but the exact pathophysiological mechanisms remain hypothetic and unresolved. Since it has been known for some years that the genes encoding for GM-CSF, IL-3 and IL-5 reside on the long arm of chromosome 5, it could be possible that the chromosomal translocation in our patient resulted in excess production of these cytokines, hence causing the hypereosinophilia. This case report and the results obtained from the literature review support the growing body of evidence that IFN-alpha has a major place in the long-term treatment of HES, especially in those cases resistant to conventional treatment, with cytogenetic abnormalities, or presenting as a myeloproliferative variant of HES. In those cases IFN-alpha results in lower morbidity, lower mortality and long-term survival.

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Eosinophilic leukaemia with trisomy 8 and double gammopathy.

Cited by 10 publications

References 5 publications

Myelodysplastic Syndrome with Clonal Eosinophilia Accompanied by Eosinophilic Pulmonary Interstitial Infiltration

Myelodysplastic Syndrome with Clonal Eosinophilia Accompanied by Eosinophilic Pulmonary Interstitial Infiltration

Chronic eosinophilic leukaemia (CEL): a distinct myeloproliferative disease

Further evidence for the clonal nature of the idiopathic hypereosinophilic syndrome: complete haematological and cytogenetic remission induced by interferon‐alpha in a case with a unique chromosomal abnormality

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