Eosinophils in chronically inflamed human upper airway tissues express transforming growth factor beta 1 gene (TGF beta 1).

Ohno, Isao; Lea, Richard G.; Flanders, K. C.; Clark, D A; Banwatt, Daljeet; Dolovich, J.; Denburg, Judah A.; Harley, Calvin B.; Gauldie, Jack; Jordana, Manel

doi:10.1172/jci115764

Cited by 221 publications

(131 citation statements)

References 32 publications

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“…Although TGF-b 1 levels are raised in the plasma of nonatopic asthmatics, this is not seen in atopic asthma [171]. TGF-b 1 levels are also increased in eosinophils from severe asthmatics at the mRNA level [172,173]. Recently, BALZAR et al [174] reported that there were more TGF-b 2 positive cells in endobronchial tissue biopsies from eosinophilic severe asthmatics.…”

Section: Involvement Of Tgf-b In Asthmamentioning

confidence: 99%

The contribution of transforming growth factor-β and epidermal growth factor signalling to airway remodelling in chronic asthma

Boxall

Holgate²,

Davies³

2006

Eur Respir J

226

187

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Asthma is increasing in prevalence in the developing world, affecting ,10% of the world's population. It is characterised by chronic lung inflammation and airway remodelling associated with wheezing, shortness of breath, acute bronchial hyperresponsiveness to a variety of innocuous stimuli and a more rapid decline in lung function over time.Airway remodelling, involving proliferation and differentiation of mesenchymal cells, particularly myofibroblasts and smooth muscle cells, is generally refractory to corticosteroids and makes a major contribution to disease chronicity. Transforming growth factor-b is a potent profibrogenic factor whose expression is increased in the asthmatic airways and is a prime candidate for the initiation and persistence of airway remodelling in asthma.This review highlights the role of transforming growth factor-b in the asthmatic lung, incorporating biosynthesis, signalling pathways and functional outcome. In vivo, however, it is the balance between transforming growth factor-b and other growth factors, such as epidermal growth factor, which will determine the extent of fibrosis in the airways.A fuller comprehension of the actions of transforming growth factor-b, and its interaction with other signalling pathways, such as the epidermal growth factor receptor signalling cascade, may enable development of therapies that control airway remodelling where there is an unmet clinical need.

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Section: Involvement Of Tgf-b In Asthmamentioning

confidence: 99%

The contribution of transforming growth factor-β and epidermal growth factor signalling to airway remodelling in chronic asthma

Boxall

Holgate²,

Davies³

2006

Eur Respir J

226

187

View full text Add to dashboard Cite

show abstract

“…Lineagespecific cytokine effects on differentiated cells, which retain hemopoietic cytokine receptors on their surface, result in "activation" or "phenotype switching": IL-3, IL-5, and GM-CSF can activate and prevent apoptosis of basophils and eosinophils (42,59); G-CSF and GM-CSF do the same for neutrophils (60). Autocrine stimulation by eosinophils, basophils, or mast cells of their own differentiation and/or activation is thus possible, since they produce a wide range of hemopoietic and proinflammatory cytokines, including IL-3, IL-4, IL-5, IL-6, and GM-CSF (33,(61)(62)(63)(64)(65)(66)(67)(68)(69).…”

Section: Cytokines and Lineage Specgcitymentioning

confidence: 99%

The role of the bone marrow in allergy and asthma

Denburg

Inman

Leber

et al. 1996

Allergy

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Summary The above studies have begun to address the fundamental question of the mechanisms of bone marrow involvement and response to allergen challenge in allergic asthmatics. Further studies in this area should complement our investigations in human asthma — which suggest that a particular bias toward differentiation of Eo‐Baso progenitors characterizes the atopic state — as well as our findings in the dog model of allergen‐induced airway hyperresponsiveness, which indicate that the bone marrow responds to inhalation of allergen or corticosteroids. Taken in the context of previous indications that IgE and bronchial responsiveness may both be transferrable through bone marrow transplantation (log), these findings indicate a physiologic role for the bone marrow in allergic inflammation. Likewise, these concepts provide a basis for making certain predictions regarding management and novel therapeutic interventions in atopy and asthma.

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“…1) (Miller el al, 1989;Gatherer et al, 1990;Millan et al, 1991;Schmid et al, 1991;Lea et al, 1992; Das et al, 1993). The northern analysis illustrated in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…RNA (Ohno et al, 1992 (Mood et al, 1974). This analysis also assumes that the differences observed are not due to the fact that the tissues are situated on different slides.…”

Section: Tissuesmentioning

confidence: 99%

“…During normal mouse pregnancy, bioactive decidual TGF-ß2 is released at the beginning of the post-implantation period when the fetus and surrounding trophoblast express MHC and non-MHC antigens of paternal origin (Lea et al, 1992 (Lea et al, in press, b). In addition to these immunosuppressive effects, TGF-ß may play a role in inhibiting the growth and invasiveness of trophoblast, and may also promote the differentiation of this tissue (Hunt et al, 1989;Clark et al, 1990;Graham et al, 1992; press, a).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Accumulation of chromotrope 2R positive cells in equine endometrium during early pregnancy and expression of transforming growth factor- 2 (TGF- 2)

Lea¹,

Stewart²,

Allen³

et al. 1995

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Eosinophils in chronically inflamed human upper airway tissues express transforming growth factor beta 1 gene (TGF beta 1).

Abstract: Transforming growth factor , (

Cited by 221 publications

References 32 publications

The contribution of transforming growth factor-β and epidermal growth factor signalling to airway remodelling in chronic asthma

The contribution of transforming growth factor-β and epidermal growth factor signalling to airway remodelling in chronic asthma

The role of the bone marrow in allergy and asthma

Accumulation of chromotrope 2R positive cells in equine endometrium during early pregnancy and expression of transforming growth factor- 2 (TGF- 2)

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