EPCR gene A3 haplotype and elevated soluble endothelial protein C receptor (sEPCR) levels in Turkish pediatric stroke patients

Ulu, Arzu; Gunal, Denizay; Tıras, Serap Teber; Eğin, Yonca; Deda, Gülhıs; Akar, Nejat

doi:10.1016/j.thromres.2006.08.004

Cited by 20 publications

(19 citation statements)

References 15 publications

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“…Ulu et al [11] confirmed these findings that there is a strong association between A3 haplotype and elevated sEPCR levels. In a study towards the polymorphisms in the EPCR gene, carriers of the 4600AG genotype had significantly higher sEPCR levels than those with the AA genotype [12].…”

Section: Discussionmentioning

confidence: 80%

Soluble endothelial protein C receptor levels in healthy population

Orhon

Ergün

Eğin

et al. 2009

J Thromb Thrombolysis

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Increased levels of sEPCR lead to dysfunction of EPCR-mediated coagulation. The aim of this present study was to determine plasma sEPCR levels in a group of Turkish healthy population including both adults and children. The study population consisted of 230 healthy individuals (108 children and 122 adults) having no acute or chronic disease. Plasma sEPCR levels were measured with ELISA. Analysis revealed a bimodal distribution in both groups. There was a negative relationship between sEPCR levels and the age of individuals (r = -0.385, P = 0.0001). The sEPCR levels of children were found significantly higher than that of adults (P < 0.001). This study is the first study to determine the relationship of sEPCR levels and terms of age. Higher levels of sEPCR may suggest a regulation mechanism for the protein C anticoagulation system over the first years of life. Further studies should be conducted to evaluate the physiological importance and molecular mechanism of increased sEPCR levels in children.

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Section: Discussionmentioning

confidence: 80%

Soluble endothelial protein C receptor levels in healthy population

Orhon

Ergün

Eğin

et al. 2009

J Thromb Thrombolysis

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“…Soluble EPCR production was decreased in cases than in control patients, both in (C/C) and (C/G) genotype carriers. In contrast, another study reported that higher soluble EPCR levels were linked with the (1651C/G) genotype [20].…”

Section: Discussionmentioning

confidence: 87%

Endothelial Cell Protein C Receptor Gene 6936a/G, 1651c/G, 4678g/C Polymorphisms and Soluble Endothelial Protein C Receptor Levels Impact on in Vitro Fertilization Outcomes

Abbassy¹

2018

HTIJ

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“…However the physiological significance of sEPCR in vivo is not well known. Soluble EPCR levels are found to be increased in patients with sepsis and systemic inflammatory disorders [5,25,48].…”

Section: Discussionmentioning

confidence: 99%

“…Haplotypes of the EPCR gene have been found to be associated with increased plasma levels of sEPCR but their association with thrombotic risk is controversial [37,38,47,48]. In addition, decreased levels of sEPCR are observed during anticoagulant therapy [42].…”

Section: Discussionmentioning

confidence: 99%