Epicatechin lowers blood pressure, restores endothelial function, and decreases oxidative stress and endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension

Gómez-Guzmán, Manuel; Jiménez, Rosario; Sánchez, Manuel; Zarzuelo, María José; Galindo, Pilar; Quintela, Ana María; López-Sepúlveda, R; Romero, Miguel; Tamargo, Juan; Vargas, Félix; Pérez‐Vizcaíno, Francisco; Duarte, Juan

doi:10.1016/j.freeradbiomed.2011.09.015

Cited by 163 publications

(149 citation statements)

References 51 publications

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“…In the light of existing reports, the fact that we see a raised activation of Nrf2 in vivo at all is astonishing: In chronic kidney disease, as well as in two hypertension models, the Dahl-sensitive hypertensive rat and the spontaneously hypertensive rat, Nrf2 activity and target gene expression were reduced (6,28,60). Only in hypertension induced by the synthetic steroid deoxycorticosterone acetat, an up-regulation was also observed (18).…”

Section: Discussionmentioning

confidence: 99%

Aldosterone Activates Transcription Factor Nrf2 in Kidney Cells both In Vitro and In Vivo

Queisser¹,

Oteiza²,

Hey³

et al. 2013

Free Radical Biology and Medicine

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Section: Discussionmentioning

confidence: 99%

Aldosterone Activates Transcription Factor Nrf2 in Kidney Cells both In Vitro and In Vivo

Queisser¹,

Oteiza²,

Hey³

et al. 2013

Free Radical Biology and Medicine

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“…The adverse effects of plasma resistin and ET-1 on endothelial function have also been found in other recent studies. 29,30 The present study revealed the ties between elevated plasma resistin level and deteriorated endothelial function in Tibetan pre-clinical male youth. To the best of our knowledge, no previous study has been done in this population group.…”

Section: Discussionmentioning

confidence: 54%

Resistin involved in endothelial dysfunction among preclinical Tibetan male young adults

Yang

Chen

et al. 2012

J Renin Angiotensin Aldosterone Syst

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Introduction: Resistin, an adipocyte-derived hormone, was found to be linked to metabolic syndrome and insulin resistance over the past decade. There is growing evidence that resistin plays a potential role in endothelial dysfunction. To the best of our knowledge, few studies have been concerned with the effect of resistin on endothelial function in a Tibetan population. Aims: To investigate the correlation of resistin and endothelial function among preclinical Tibetan male young adults. Materials and methods: All participants recruited were young adults between 30 and 40 years old of male gender in Lhasa city. All subjects were native Tibetan. A total of 90 healthy subjects were accepted after excluding hypertension, diabetes, hyperlipidemia or coronary artery disease. The subjects were divided into three groups according to flow-mediated dilation (FMD): lower FMD (group A), intermediate FMD (group B) and higher FMD (group C). Body mass index, systolic blood pressure (SBP), diastolic blood pressure (DBP) and cigarette smoking were evaluated. Venous blood was sampled for the measurement of lipid profile, fasting blood glucose (FBG), fasting insulin (FINS), endothelin-1 (ET-1) and plasma resistin quantitation. The non-invasive vascular endothelial function was evaluated through the measurement of FMD with B-mode ultrasound. The insulin resistance was estimated as homeostatic model assessment of insulin resistance (HOMA-IR) = FINS(mu/L)*FBG(mmol/L)/22.5. Results: No statistical significance was found between groups in age, smoking, SBP, DBP, fasting insulin, total cholesterol and HOMA-IR (p>0.05). In the lipid profile, high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol in group C were better than in groups A and B (p<0.01). Body mass index, which is an indicator for obesity, was much lower in group C than in group A and B (p<0.05 and 0.01 respectively). Comparison of plasma resistin concentrations: group A > group B > group C (p<0.01). Comparison of plasma ET-1 concentrations had a similar result: group A > group B > group C (p<0.05). The multivariate regression analysis showed that total cholesterol (p<0.05), LDL cholesterol (p<0.01), plasma resistin (p<0.01) and plasma ET-1 (p<0.01) were correlated with FMD. Conclusions: Resistin is involved in endothelial dysfunction in preclinical male young Tibetan adults.

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“…Upon activation by oxidative stress Nrf2 translocates to the nucleus where it binds to the ARE, triggering the transcription of antioxidant defense enzymes such as SOD-1 and HO-1, thus protecting tissues from oxidative injury indicated increased ET-1 mRNA level in liver and kidney in mice during oxidative stress induced by oxidized casein [38]. Likewise, Gomez-Guzman et al observed increased plasma ET-1 level and enhanced expression of Nrf2 mRNA in aortic rings in DOCA (deoxycorticosterone acetate) -salts rats [37].…”

Section: Discussionmentioning

confidence: 99%

Inhibitor of NF B pathway JSH 23 inhibit oxidative stress generated by endothelin 1 ET 1

Gorąca¹,

Skibska²

2016

Fifth International Conference on Advances in Applied Science and Environmental Technology- ASET 2016

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Epicatechin lowers blood pressure, restores endothelial function, and decreases oxidative stress and endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension

Cited by 163 publications

References 51 publications

Aldosterone Activates Transcription Factor Nrf2 in Kidney Cells both In Vitro and In Vivo

Aldosterone Activates Transcription Factor Nrf2 in Kidney Cells both In Vitro and In Vivo

Resistin involved in endothelial dysfunction among preclinical Tibetan male young adults

Inhibitor of NF B pathway JSH 23 inhibit oxidative stress generated by endothelin 1 ET 1

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