Epicutaneous allergen administration as a novel method of allergen-specific immunotherapy

Senti, Gabriela; Graf, Nicole; Haug, Susanne; Rüedi, Nadine; Moos, Seraina von; Sonderegger, Theodor; Johansen, Pål; Kündig, Thomas M.

doi:10.1016/j.jaci.2009.07.019

Cited by 181 publications

(161 citation statements)

References 33 publications

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“…Oral SIT possesses a high potential for the development of novel treatment modalities. In fact such approaches including oral immunotherapy for food allergy are under development [89][90][91][92][93].…”

Section: Clinical Usementioning

confidence: 99%

Mechanisms of allergen-specific immunotherapy

Akdiş

2011

Journal of Allergy and Clinical Immunology

462

264

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Section: Clinical Usementioning

confidence: 99%

Mechanisms of allergen-specific immunotherapy

Akdiş

2011

Journal of Allergy and Clinical Immunology

462

264

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“…4 The intranasal route has been tried since the late 90s by Italian teams, 5,6 has been marketed in this country and still appears in a recent Taiwanese publication; 7 the oral route failed to demonstrate efficacy in respiratory allergies but seems promising in food allergy treatment; 8 the epicutaneous route, using patch tests (applied on the skin for a period of one to several days) was studied with grass pollens in one publication where efficacy in lowering allergic rhinitis symptoms was demonstrated. 9 Finally, a new promising route of administration has been recently explored with intralymphatic allergen injections. 10 In humans, 3 injections in a lymph node seems to be as efficient on rhinoconjunctivitis symptoms as three years of subcutaneous immunotherapy.…”

Section: Introductionmentioning

confidence: 99%

Specific immunotherapy in grass pollen allergy

Mailhol

Didier²

2012

Human Vaccines & Immunotherapeutics

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“…AIT aims to induce changes on the immune response of allergic individuals, drawing a state of allergen-specific tolerance, which contributes with a curative effect for a long period of time [28][29][30][31][32].…”

Section: Cellular and Molecular Mechanisms Of Aitmentioning

confidence: 99%

Allergen-Specific Immunotherapy Follow-Up by Measuring Allergen-Specific IgG as an Objective Parameter

Taketomi¹,

Miranda²,

Júnior³

et al. 2017

Immunotherapy - Myths, Reality, Ideas, Future

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The clinical efficacy of the allergen-specific immunotherapy (AIT) has been well-documented using inhalant or hymenoptera-derived allergens in atopic patients with corresponding specific IgE antibodies. AIT is considered as the unique treatment that is capable of modifying the natural course of the allergic disease because it induces a variety of immunological mechanisms, with emphasis in the production of blocking IgG antibodies by IL-10-stimulated B cells due to the generation of Treg, Breg, or even Th2 cells. Thus, the measurement of specific IgG subclasses, particularly IgG4, to the crude extract or more importantly to allergen components, might be a useful and potential tool to follow-up objectively the patients undergoing AIT in addition to clinical parameters. In this chapter, the authors have emphasized a very sensitive and highly specific reverse ELISA, developed by them, to measure IgG subclasses directed to clinically relevant natural allergens that are undoubtedly better when compared to those obtained with recombinant counterparts. Such a technique may produce more authentic results taking into account the IgG subclass binding capacity to a particular allergen and might be a valuable and alternative method for monitoring activation of tolerance-inducing mechanisms in patients under AIT.

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Epicutaneous allergen administration as a novel method of allergen-specific immunotherapy

Cited by 181 publications

References 33 publications

Mechanisms of allergen-specific immunotherapy

Mechanisms of allergen-specific immunotherapy

Specific immunotherapy in grass pollen allergy

Allergen-Specific Immunotherapy Follow-Up by Measuring Allergen-Specific IgG as an Objective Parameter

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