Epicutaneous Tests with Detergents and a Number of other Common Allergens

A, Nilzen; Voss-Lagerlund, K.

doi:10.1159/000255056

Cited by 17 publications

(6 citation statements)

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“…Skin reactivity seems also to change depending on age, although contradictory findings are reported. For example, Nilzen and Voss Lagerlung observed higher reactivity patch test reactions to soaps and detergents in elderly, whereas Bettley and Donoghue reported a lower reactivity in the same group. Coenraads demonstrated a higher skin reactivity to croton oil in the older patient group, but no differences by testing thimochinone or croton aldehyde.…”

Section: Methodsmentioning

confidence: 99%

Sensitive skin: an overview

Berardesca

Farage

Maibach

2012

Intern J of Cosmetic Sci

164

144

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SynopsisSensitive skin is a condition of subjective cutaneous hyper-reactivity to environmental factors. Subjects experiencing this condition report exaggerated reactions when their skin is in contact with cosmetics, soaps and sun screens, and they often report worsening after exposure to dry and cold climate. Although no sign of irritation is commonly detected, itching, burning, stinging and a tight sensation are constantly present. Generally substances that are not commonly considered irritants are involved in this abnormal response.Sensitive skin and subjective irritation are widespread but still far from being completely defined and understood. A correlation between sensitive skin and constitutional anomalies and/or other triggering factors such as occupational skin diseases or chronic exposure to irritants has been hypothesized. Recent findings suggest that higher sensitivity can be due to different mechanisms. Hyper-reactors may have a thinner stratum corneum with a reduced corneocyte area causing a higher transcutaneous penetration of water-soluble chemicals. Alterations in vanilloid receptors and changes in neuronal transmission have been described. Monitoring skin parameters such as barrier function, proclivity to irritation, corneocyte size and sensorial transmission can also be useful to identify regional differences in skin sensitivity. Ré suméLa peau sensible est une condition de l'hyperréactivité cutanée subjective à des facteurs environnementaux. Les sujets souffrant de cette condition signalent des réactions exagérées lorsque leur peau est en contact avec des cosmétiques, des savons et des écrans solaires, et ils mentionnent souvent une aggravation après une exposition à un climat sec et froid. Bien qu'aucun signe d'irritation ne soit généralement détecté, les démangeaisons, sensations de brû -lure, de picotement et tiraillement sont constamment présentes. En général, les substances qui ne sont pas habituellement considérées comme irritantes sont impliquées dans cette réponse anormale. La peau sensible et l'irritation subjective sont largement répandues mais encore loin d'être complètement définies et comprises. Une corrélation entre la peau sensible et les anomalies constitutionnelles et / ou d'autres facteurs déclenchants tels que les maladies professionnelles de la peau ou l'exposition chronique à des irritants a été émise comme hypothèse. Des découvertes récentes suggèrent qu'une sensibilité augmentée peut être due à différents mécanismes. Les hyperréactifs peuvent présenter une couche cornée mince avec une zone de cornéocytes réduite entraînant une meilleure pénétra-tion transcutanée de produits chimiques solubles dans l'eau. Des modifications des récepteurs vanilloïdes et des changements dans la transmission neuronale ont été décrits. La surveillance des paramètres de la peau telles que la fonction de barrière, la propension à l'irritation, la taille des cornéocytes et de la transmission sensorielle peut également être utile pour identifier les différences régionales dans la sensibilité cut...

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Section: Methodsmentioning

confidence: 99%

Sensitive skin: an overview

Berardesca

Farage

Maibach

2012

Intern J of Cosmetic Sci

164

144

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“….. (56)). (70) women and 53 years for men. In another study, out of 134 volunteers, a general sensitivity to 3 or more allergens was found in 32%, and was also evident in 2/3 ofthe men.…”

Section: Sexmentioning

confidence: 97%

Effect of age and sex on the elicitation of irritant contact dermatitis

Patil

Maibach

1994

Contact Dermatitis

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Irritant contact dermatitis causes significant disability to numerous consumers and individuals in industry. Knowledge of the prevalence of this disease remains inadequate. Irritant contact dermatitis occurs in workers engaged in occupations where the subjects are exposed to different types and doses of irritants. The intensity of the reaction depends on the quality and the quantity of exposure. Irritant thresholds and dose responses depend on many different factors. This article reviews the clinical and physiological parameters that affect the age and sex related differences in irritant contact dermatitis.

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“…Skin reactivity seems also to change depending on age, although contradictory findings are reported in the literature. For example Nilzen and Voss Lagerlung [27] reported higher reactivity patch test reactions to soaps and detergents in elderly, whereas Bettley and Donoghue [28] reported a lower reactivity in the same group. Coenraads et al [29] demonstrated a higher skin reactivity to croton oil in the older patient group, but no differences by testing thimochinone or croton aldehyde.…”

Section: Epidemiologic Studiesmentioning

confidence: 99%

Sensitive skin: mechanisms and diagnosis

Primavera

Berardesca

2005

Intern J of Cosmetic Sci

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Sensitive skin is a condition of subjective cutaneous hyperreactivity to environmental factors. Subjects experiencing this condition report exaggerated reactions when their skin is in contact with cosmetics, soaps and sunscreens, and they often report worsening after exposure to dry and cold climate. Although no sign of irritation is commonly detected, itching, burning, stinging and a tight sensation are constantly present. Generally substances that are not commonly considered irritants are involved in this abnormal response. They include many ingredients of cosmetics such as: dimethyl sulfoxide, benzoyl peroxide preparations, salicylic acid, propylene glycol, amyldimethylaminobenzoic acid and 2-ethoxyethyl methoxycinnamate. Sensitive skin and subjective irritation are widespread but still far from being completely defined and understood. The aim of this paper is to summarize the relevant literature in order to elucidate the underlying mechanisms of sensitive skin and the best testing methodologies for investigation of sensitive skin.

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Epicutaneous Tests with Detergents and a Number of other Common Allergens

Cited by 17 publications

References 0 publications

Sensitive skin: an overview

Sensitive skin: an overview

Effect of age and sex on the elicitation of irritant contact dermatitis

Sensitive skin: mechanisms and diagnosis

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