Epidemic Bronchiolitis in Infants

Disney, M. E.; Sandiford, B. R.; Cragg, John; Wolff, Jill

doi:10.1136/bmj.1.5183.1407

Cited by 38 publications

(20 citation statements)

References 10 publications

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“…In our diagnostic criteria for acute bronchiolitis we did not exclude cases who had previous wheezing episodes, and it is possible that patients with early onset asthma might have been included. Mortality from bronchiolitis among infants less than 1 year of age was reported to be 4-7 % for infants hospitalized in the 1960s [10,11]; however, it has dropped to less than 1 % in the last decade [12]. There were no deaths from bronchiolitis in PWH during the study period; this may reflect an ethnic difference or a different viral aetiology.…”

Section: Discussionmentioning

confidence: 99%

“…The average age was 5 months and the mean duration of hospital stay 5 days (range 2-63 days). The mean interval between the onset of illness and admission was 3 days (range [1][2][3][4][5][6][7][8][9][10][11] Seasonal variation of RSV isolation During the course of the study marked seasonal variation in the rate of RSV isolation was found. There was a clear seasonal periodicity with RSV isolation peaking in summer and disappearing in winter.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology and aetiology of acute bronchiolitis in Hong Kong infants

Sung¹,

Chan

Tam

et al. 1992

Epidemiol. Infect.

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SUMMARYThe epidemiological, clinical and virological features of 1220 children with acute bronchiolitis admitted to the Prince of Wales Hospital, Hong Kong, from 1985 to 1988 are reported. They accounted for 6·6% of total paediatric admissions and provided a case incidence of bronchiolitis requiring admission to hospital of approximately 21 per 1000 children 0–24 months of age.The clinical course and outcome was in general benign. The average hospital stay was 5 days and there were no deaths. Ten per cent of patients were repeatedly admitted to hospital with recurrent wheezing after discharge. Two infants developed bronchiolitis obliterans.Respiratory syncytial virus (RSV) was shown by direct immunofluorescence, virus culture and serology to be the commonest cause of acute bronchiolitis in Hong Kong. Other aetiological agents included parainfluenza and influenza viruses, adenoviruses, and Mycoplasma pneumoniae.In contrast to western countries, a seasonal variation of bronchiolitis was found with a peak incidence in the summer months. The significance of these observations is discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Epidemiology and aetiology of acute bronchiolitis in Hong Kong infants

Sung¹,

Chan

Tam

et al. 1992

Epidemiol. Infect.

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“…When these conditions are considered together as "bronchiolitis" the mortality rate is about 5 % (Heycock and Noble, 1956Noble, , 1962Disney et al, 1960) compared with 1-2% in series where the diagnosis "bronchiolitis" is made on stricter criteria (High, 1957; E.lderkin et al, 1965;Court, 1973).…”

Section: Introductionmentioning

confidence: 99%

“…Many of these deaths occur at home but even in hospital-based series the mortality rate is high (Disney et al, 1960;Heycock and Noble, 1962;Court, 1973). In more than a third of the cases predisposing disease or malformation is present (Court, 1973).…”

mentioning

confidence: 99%

Virological Findings and Blood Gas Tensions in Acute Lower Respiratory Tract Infections in Children

Simpson¹,

Matthew²,

Inglis³

et al. 1974

BMJ

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Summary Sequential blood gas tensions and pH have been measured in 84 children selected from 486 admitted to hospital during a 15-month period with acute lower respiratory tract infections. Of those selected 73 were treated conservatively and 11 by intermittent positive-pressure ventilation; one infant in the latter group died. Respiratory syncytial virus (R.S.V.) was isolated from 24 out of 62 patients studied and the main pathogen in the most severely affected infants. Statistical analysis showed that age and R.S.V. infection were independent determinants of severity, as reflected by a peak Pco2 measurement at the height of the iliness (age, P < 001; R.S.V. 0-05 > P > 001). IntroductionIn Britain acute lower respiratory tract infections (bronchitis, bronchiolitis, and bronchopneumonia) are the main respiratory illnesses causing adrmission to hospital of children under the age of 2 years. When these conditions are considered together as "bronchiolitis" the mortality rate is about 5 % (Heycock and

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Section: Introductionmentioning

confidence: 99%