Many industries and systems have faced consequences as a result of the COVID-19 outbreak. In this time, we are happy to had the publication of a Special Issue of Applied System Innovation titled “Systems and Industries in Response to the COVID-19 Crisis”. This editorial article contains the special issue’s closing remarks. However, while the scope of this given special issue grabbed the interest of practitioners and scholars, there is still much to be learned from COVID-19’s experience. Thus, suggestions for future special issues are included with this letter.