Epidemiologic Features of Appendicitis

Sanda, Robert B

doi:10.5772/26110

Cited by 3 publications

(1 citation statement)

References 120 publications

(96 reference statements)

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“…Fecaliths are found in one-third of specimens. In the other cases, obstruction is thought to be caused by hypertrophy of mural lymphoid follicles in response to diverse causes [1]. The peak incidence of appendicitis coincides with the age when the immune response is most vigorous, and the lymphoid follicles are at their maximum development [2].…”

Section: Introductionmentioning

confidence: 99%

A Th2 Cytokine Profile in Appendicular Lavage Fluid Suggests Allergy as a Possible Etiology for Acute Appendicitis

Carvalho

Barros

Coelho

et al. 2019

Mediators of Inflammation

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Acute appendicitis is the most frequent surgical abdominal emergency, but its etiology remains poorly understood. Histological examination of the appendix, following its removal due to acute appendicitis, consistently shows features in common with bronchial asthma, suggesting an allergic reaction as a candidate etiologic factor. Here, we propose the concept of appendicular lavage and use it to study the levels of the Th2 cytokines IL-4, IL-5, and IL-9 in patients with a clinical diagnosis of acute appendicitis. The study group included 20 patients with a histological diagnosis of phlegmonous appendicitis, 13 patients with gangrenous appendicitis, and a control group of 8 patients with a clinical diagnosis of appendicitis but with normal histology. Cytokine levels were higher in acute appendicitis. The difference was more pronounced when comparing phlegmonous appendicitis with nonpathological appendicitis (p = 0.01) for IL-4 (48.3 vs. 21.3 pg/mL), IL-5 (29.2 vs. 8.0 pg/mL), and IL-9 (34.1 vs. 16.6 pg/mL). This Th2 cytokine profile is compatible with the hypothesis of allergy as an etiologic factor for acute appendicitis and may have important implications for the diagnosis, prevention, and treatment of this condition.

show abstract

Section: Introductionmentioning

confidence: 99%

A Th2 Cytokine Profile in Appendicular Lavage Fluid Suggests Allergy as a Possible Etiology for Acute Appendicitis

Carvalho

Barros

Coelho

et al. 2019

Mediators of Inflammation

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The Association Between Barium Examination and Subsequent Appendicitis: A Nationwide Population-Based Study

Yeh

Huang

et al. 2017

The American Journal of Medicine

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Th2 cytokine profile in appendicular lavage fluid is compatible with allergy as an etiology for acute appendicitis

Carvalho

Barros

et al. 2019

Preprint

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Acute appendicitis is the most frequent surgical abdominal emergency, but its etiology remains poorly understood. Histological examination of the appendix, following its removal due to acute appendicitis, consistently shows features in common with bronchial asthma, suggesting an allergic reaction as a candidate etiologic factor. Here we propose the concept of appendicular lavage and used it to study the levels of the Th2 cytokines IL-4, IL-5 and IL-9 in patients with a clinical diagnosis of acute appendicitis. The study group included 20 patients with a histological diagnosis of phlegmonous appendicitis, 13 patients with gangrenous appendicitis, and a control group of 8 patients with clinical diagnosis of appendicitis but with normal histology. Cytokines levels were higher in acute appendicitis. The difference was more pronounced when comparing phlegmonous appendicitis with non-pathological appendix (p=0.01) for IL-4 (48,3 vs 21,3 pg/mL), IL-5 (29,2 vs 8,0 pg/mL) and IL-9 (34,1 vs 16,6 pg/mL). This Th2 cytokine profile is compatible with the hypothesis of allergy as an etiologic factor for acute appendicitis and may have important implications for the diagnosis, prevention and treatment of this condition.

show abstract

Epidemiologic Features of Appendicitis

Cited by 3 publications

References 120 publications

A Th2 Cytokine Profile in Appendicular Lavage Fluid Suggests Allergy as a Possible Etiology for Acute Appendicitis

A Th2 Cytokine Profile in Appendicular Lavage Fluid Suggests Allergy as a Possible Etiology for Acute Appendicitis

The Association Between Barium Examination and Subsequent Appendicitis: A Nationwide Population-Based Study

Th2 cytokine profile in appendicular lavage fluid is compatible with allergy as an etiology for acute appendicitis

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