Epidemiological and clinical characteristics of children with human parainfluenza virus associated acute respiratory infection in a general hospital in Sri Lanka

Rafeek, Rukshan A M; Divarathna, M.; Morel, A. J.; Noordeen, F.

doi:10.1016/j.jcvp.2021.100049

“…Contrasted with a study During the first and second wave of the 2009 H1N1 pandemic, a significant majority of patients hospitalized with severe 2009 H1N1 disease was young adult females (15-49 years of age) (Klein et al, 2012) . In this study ,we found percentage of males 7.30% a higher than females 6.70% .In another study, the ratio of males to females infected with the HPIV3 was 19:15 (Rafeek et al, 2021) . The results of present study revealed there are significant differences between the age groups and the percentage of H1N1virus positive patients with highest value was (2.70%) at both age group of (Less Than 7…”

Section: The Resultssupporting

confidence: 54%

“…Years) and (64-70 Years), and the lowest one was (0%) at age group of (22)(23)(24)(25)(26)(27)(28) . which is in accordance with the studies reported from Iran In this study , Where they found most of those infected with the H1N1 virus were than less than 7 years , 64-70 Years .…”

Section: The Resultsmentioning

confidence: 90%

Comparative Study of Influenza Virus and Parainfluenza 3 Virus as Causative Agents of Upper Respiratory System in Thi-Qar Province

Ghazi¹,

Ghazi²

2022

UTJsci

0

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The current study is targeted for detection of the some important respiratory pathogen viruses which responsible for respiratory tract infections, Influenza A virus (IAV) and human Parainfluenza viruses (HPIVs) are considered of the causes of respiratory diseases. The current study included the examination of 150 nasal swab samples from the age of one year to the age of 70 years. The collected specimens were kept in viral transport media (VTM). RNA were extracted.The results revealed from this study are summarized in the follows: out of 150 patients suffering from respiratory tract infection only 20(13.3%) were encountered with the H1N1 virus, 21(14.0%) were HPIV3 .Co-infection of number of viruses appeared in 33(22.0%) patient. The sample are categorized into sex groups were H1N1viruses male 12(8.00%) higher than female 8(5.30%). HPIV3 male 11(7.30%) higher female 10(6.70%).The distribution of H1N1virus based on age groups ,and it represents the highest percentage were 4(2.70%) less than 7 years, 3(2.00%) (57-63)years and 4(2.70%)(64-70)years.The distribution of HPIV3 based on age group, and represents the highest percentage were 4(2.70%)(57-63)years, 4(2.70%)(64-70)years. H1N1virus infections in the December, January, February and March months was higher than the April, HPIV3 infection in the March and April months were higher than the December, January and February months. The main clinical features caused by H1N1, rhinorrhea ,fever and cough were reported as the highest frequently,15(75.0%), 10(50.0%), 9(45.0%) respectively ,the other signs were dyspnea 7(35.0%), sneezing 5(25.0%). HPIV3, rhinorrhea was reported as the highest frequently 16(76.2%), the other signs were sneezing 5(23.8%), cough and fever 4(19.0%) for each of them,dyspnea 2(9.50%). In the present study, the highest H1N1infection was recorded in Nasiriyah district 6(30.0%), followed by Al-Dawaya 4(20.0%), recorded in both of SuqAlshyuokh and Al-Shatrah 3(15.0%), recorded in both of Al-Garraf and Al-Rifai 2(10.0%). The highest HPIV3 infections were recorded in both Nasiriyah, Al-Rifai, and Al-Shatrah, 7( 33.3%) ,5(23.8%), 4(19.0%) respectively, recorded in both of SuqAlshyuokh, Al-Dawaya 2(9.50%), followed by Al-Garraf 1(4.80%).

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“…In the study ,we found percentage HPIV2 of females 4.00% a higher than male 3.30% .Don't agree with Some studies show a higher proportion of young male infected by HPIV than young female, and such an incidence of infection becomes similar to the sex as age increases (Gregianini et al, 2019) . In another study, the ratio of males to females infected with the HPIV2 was 3:5 (Rafeek et al, 2021). In this study ,we found percentageHPIV3 of males 7.30% a higher than females 6.70% .In another study, the ratio of males to females infected with the HPIV3 was 19:15 (Rafeek et al, 2021) .…”

Section: Discussionsupporting

confidence: 55%

“…In another study, the ratio of males to females infected with the HPIV2 was 3:5 (Rafeek et al, 2021). In this study ,we found percentageHPIV3 of males 7.30% a higher than females 6.70% .In another study, the ratio of males to females infected with the HPIV3 was 19:15 (Rafeek et al, 2021) . Also in another study, the proportion of males(50.0%) is higher than that of females (49.0%) (Fathima et al, 2016).…”

Section: Discussionsupporting

confidence: 55%

“…The results of present study revealed there are significant differences between the age groups and the percentage of HPIV2 positive patients with highest value was (2.00%) of (Less Than 7 Years) . the lowest one was (0%) at age group of (15)(16)(17)(18)(19)(20)(21). While in another study ; Depending on the age group, the prevalence of HPIV types showed significant differences.…”

Section: Discussionmentioning

confidence: 77%

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Epidemiological and Molecular Study of Influenza and Parainfluenza Viruses of Respiratory System Infections in Thi-Qar Province, Iraq

2022

pnr

0

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The current study is targeted for detection of the some important respiratory pathogen viruses which responsible for respiratory tract infections, Influenza A virus ( IAV ) and human Parainfluenza viruses (HPIVs) are considered of the causes of respiratory diseases . The current study included the examination of 150 nasal swab samples from the age of one year to the age of 70 years. The collected specimens were kept in viral transport media (VTM). RNA were extracted .The results revealed from this study are summarized in the follows : out of 150 patients suffering from respiratory tract infection only 20(13.3%) were encountered with the H1N1 virus ,23(15.3%) were HPIV1 virus , 11(7.30%) were HPIV2 ,21(14.0%) were HPIV3 .Co-infection of number of viruses appeared in 33(22.0%) patient. The sample are categorized into sex groups were H1N1viruses male 12(8.00%) higher than female 8(5.30%). HPIV1 male 13(8.70%) higher than female 10(6.70%),HPIV2 female 6(4.00%) higher male 5(3.30%), HPIV3 male 11(7.30%) higher female 10(6.70%).The distribution of H1N1virus based on age groups ,and it represents the highest percentage were 4(2.70%) less than 7 years, 3(2.00%) (57-63)years and 4(2.70%)(64-70)years .The distribution of HPIV1,2,3 based on age group , and represents the highest percentage were HPIV1 , 5(3.30%) less than 7 years,4(2.70%)(57-63)years and 5(3.30%)(64-70) years ,HPIV2, 3(2.00%)( less than 7 years) ,HPIV3 ,4(2.70%)(57-63)years ,4(2.70%)(64-70)years.

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Epidemiology and risk factors of respiratory syncytial virus associated acute respiratory tract infection in hospitalized children younger than 5 years from Sri Lanka

Divarathna,

Rafeek,

Morel

et al. 2023

Front. Microbiol.

4

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BackgroundRespiratory syncytial virus (RSV) is the leading cause of acute respiratory tract infections (ARTI) and a major cause of morbidity and mortality in children worldwide.AimThis study aimed to describe the prevalence and seasonal patterns of RSV and to determine the actual and predictive association of RSV-associated ARTI and clinical, socio-demographic, and climatic risk factors in children < 5 years.MethodsNasopharyngeal aspirates were collected from 500 children < 5 years admitted to the Kegalle General Hospital, Sri Lanka between May 2016 to July 2018. RSV and RSV subtypes were detected using immunofluorescence assay and real time RT-PCR, respectively. Descriptive and inferential statistics were done for the data analysis using Chi-square, Fisher’s exact, Kruskal–Wallis test, and multiple binary logistic regression in the statistical package for social sciences (SPSS), version 16.0.ResultsPrevalence of RSV-associated ARTI was 28% in children < 5 years. Both RSV subtypes were detected throughout the study period. RSV-B was the dominant subtype detected with a prevalence of 72.14%. RSV infection in general caused severe respiratory disease leading to hypoxemia. Compared to RSV-B, RSV-A infection had more symptoms leading to hypoxemia. Factors increasing the risk of contracting RSV infection included number of people living (n > 6), having pets at home and inhaling toxic fumes. The inferential analysis predicts RSV infection in children < 5 years with ARTI, with a 75.4% probability with clinical and socio-demographic characteristics like age < 1 year, fever for > 4 days, cough, conjunctivitis, stuffiness, fatigue, six or more people at home, having pets at home and inhaling toxic fumes. Climatic factors like increases in temperature (°C), wind speed (Km/h), wind gust (Km/h), rainfall (mm) and atmospheric pressure (mb) showed a strong correlation with the RSV infection in children.

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Epidemiological and clinical characteristics of children with human parainfluenza virus associated acute respiratory infection in a general hospital in Sri Lanka

Cited by 3 publications

References 26 publications

Comparative Study of Influenza Virus and Parainfluenza 3 Virus as Causative Agents of Upper Respiratory System in Thi-Qar Province

Comparative Study of Influenza Virus and Parainfluenza 3 Virus as Causative Agents of Upper Respiratory System in Thi-Qar Province

Epidemiological and Molecular Study of Influenza and Parainfluenza Viruses of Respiratory System Infections in Thi-Qar Province, Iraq

Epidemiology and risk factors of respiratory syncytial virus associated acute respiratory tract infection in hospitalized children younger than 5 years from Sri Lanka

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