Epidemiological and genetic characteristics associated with the severity of acute viral bronchiolitis by respiratory syncytial virus

Alvarez, Alfonso Eduardo; Marson, Fernando Augusto Lima; Bertuzzo, Carmen Sílvia; Arns, Clarice Weis; Ribeiro, José Dirceu

doi:10.1016/j.jped.2013.02.022

Cited by 66 publications

(72 citation statements)

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“…The considerable number of tests and RSV positive results in infants younger than six months of age and the peak in number and percentage of positive RSV tests in infants aged one month is consistent with existing literature that reports age under six months as a significant risk factor for severe RSV infection (21) and a peak in RSV bronchiolitis at age one month (12) (22). Young infants have been a high priority for vaccination due to the serious complications and subsequent morbidity that can occur following RSV infection in early life (6).…”

Section: Discussionsupporting

confidence: 89%

Epidemiology of laboratory-confirmed respiratory syncytial virus infection in young children in England, 2010–2014: the importance of birth month

et al. 2016

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SummaryThe epidemiology of laboratory-confirmed RSV infections in young children has not recently been described in England, and is an essential step in identifying optimal target groups for future licensed RSV vaccines. We used two laboratory surveillance systems to examine the total number and number of positive RSV tests in children less than five years old in England from 2010-2014. We derived odds ratios with 95% confidence intervals comparing children by birth month, using multivariable logistic regression models adjusted for age, season and sex. 47% of RSV tests (29,851/63,827) and 57% (7,405/13,034) of positive results in children under five years old were in infants younger than six months. Moreover, 38% (4,982/13,034) of positive results were in infants younger than three months.Infants born in September, October and November had the highest odds of a positive RSV test during their first year of life compared to infants born in January (OR=2.1 (95% CI 1.7, 2.7), OR=2.4 (95% CI 2.1, 2.8) and OR=2.4 (95% CI 2.1, 2.7), respectively). Our results highlight the importance of young age and birth month near the beginning of RSV season to the risk of laboratory confirmed RSV infection. Future control measures should consider protection for these groups.3

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Section: Discussionsupporting

confidence: 89%

Epidemiology of laboratory-confirmed respiratory syncytial virus infection in young children in England, 2010–2014: the importance of birth month

et al. 2016

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“…Risk factors of RSV positive LRTI are not well defined in our country. In our study, we found risk factors for RSV positivity such as: to be younger than six months, having a low socioeconomic status, shorter duration of breastfeeding and spontaneous [21], assesed the risk factors for RSV bronchiolitis by data synthesis of 60 relevant studies. They found low socioeconomic status and lack of breastfeeding as risk factors which are similar to our study.…”

Section: Discussionmentioning

confidence: 69%

RSV infection in Istanbul: risk factors and frequency

Güllü

Akın

Karaaslan

et al. 2017

J Infect Dev Ctries

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Introduction: Respiratory syncytial virus (RSV) is one of the most common causes of acute respiratory infections in all age groups especially under two years. The aim of this study was to investigate the frequency and clinical features of RSV in hospitalized children under two years of age with the diagnosis of lower respiratory tract infections (LRTI) in our region. Methodology: Between September 2011-May 2013, hospitalized children aged 0-2 years with the diagnosis of viral LRTI, in which nasopharengeal secretions were tested for the presence of the RSV antigen, were included in this prospective study. Results: Among the total of 361 hospitalized children who were investigated for RSV antigen, 138 (38%) were female and 223 (62%) were male. The mean age of the group was 5,7±5,1 months (0-24 months). RSV antigen in nasopharyngeal secretions was positive in 68 (19%) of 361 patients. RSV infection was detected significantly higher in December and January (p = 0.003). RSV positivity was significantly higher in patients aged under 6 months (p=0.01), with shorter duration of breastfeeding (p = 0.02), low socioeconomic status (p = 0.02), and also born with spontaneous vaginal delivery (p = 0.007). In RSV(+) LRTI group, children were associated with severe disease than RSV (-LRTI group (p = 0.014). Conclusions: Since there is lack of data investigating the frequency and the risk factors of RSV respiratory infections in our region, the present study is important for providing new data. Furthermore, this is the second study investigating the correlation between RSV positivity and meteorological conditions in Turkey.

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“…A idade média das crianças incluídas no nosso estudo foi de 1,88±1,25 meses. Estudo realizado na Espanha avaliou 229 pacientes internados em UTI pediátrica por BVA e constatou que a idade foi inversamente proporcional ao tempo necessário de suporte ventilatório e de dias de internação em UTI 18,19,20 . Um estudo realizado nos Estados Unidos apontou que de 1,1 milhão de crianças menores de dois anos internadas por VSR em um período de oito anos, a maior porcentagem das internações ocorreu na faixa etária entre três e seis meses 21 .…”

Section: Discussionunclassified

Ventilação mecânica não invasiva na bronquiolite viral aguda: estudo de coorte retrospectivo

et al. 2017

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Epidemiological and genetic characteristics associated with the severity of acute viral bronchiolitis by respiratory syncytial virus

Abstract: the severity of AVB by RSV is a phenomenon that depends on the varying degrees of interaction among epidemiological, environmental, and genetic variables.

Cited by 66 publications

References 50 publications

Epidemiology of laboratory-confirmed respiratory syncytial virus infection in young children in England, 2010–2014: the importance of birth month

Epidemiology of laboratory-confirmed respiratory syncytial virus infection in young children in England, 2010–2014: the importance of birth month

RSV infection in Istanbul: risk factors and frequency

Ventilação mecânica não invasiva na bronquiolite viral aguda: estudo de coorte retrospectivo

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