Epidemiological characteristics of most relevant digestive system diseases of infectious nature in the regions of Russia

Антипов, М. О.; Mindlina, A. Ya.

doi:10.17116/profmed20202303176

Cited by 7 publications

(1 citation statement)

References 7 publications

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“…However, in PBC, the level of IgM-related AMAs does not decline over the course of the disease, which does not align with the bacterial nature of antigens triggering the production of AMAs. With continuous exposure to thymus-independent antigens and decreased immune tolerance to them, IgM synthesis can become stable[ 16 ]. However, there is low likelihood that bacterial antigen is constantly present in patients with PBC and triggers the production of AMAs[ 10 ].…”

Section: Amas and The Theory Of Antigenic Mimicrymentioning

confidence: 99%

New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage

Reshetnyak,

Maev

2023

World J Gastroenterol

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Acute pancreatitis (AP) is a potentially life-threatening inflammatory disease of the pancreas, with clinical management determined by the severity of the disease. Diagnosis, severity prediction, and prognosis assessment of AP typically involve the use of imaging technologies, such as computed tomography, magnetic resonance imaging, and ultrasound, and scoring systems, including Ranson, Acute Physiology and Chronic Health Evaluation II, and Bedside Index for Severity in AP scores. Computed tomography is considered the gold standard imaging modality for AP due to its high sensitivity and specificity, while magnetic resonance imaging and ultrasound can provide additional information on biliary obstruction and vascular complications. Scoring systems utilize clinical and laboratory parameters to classify AP patients into mild, moderate, or severe categories, guiding treatment decisions, such as intensive care unit admission, early enteral feeding, and antibiotic use. Despite the central role of imaging technologies and scoring systems in AP management, these methods have limitations in terms of accuracy, reproducibility, practicality and economics. Recent advancements of artificial intelligence (AI) provide new opportunities to enhance their performance by analyzing vast amounts of clinical and imaging data. AI algorithms can analyze large amounts of clinical and imaging data, identify scoring system patterns, and predict the clinical course of disease. AI-based models have shown promising results in predicting the severity and mortality of AP, but further validation and standardization are required before widespread clinical application. In addition, understanding the correlation between these three technologies will aid in developing new methods that can accurately, sensitively, and specifically be used in the diagnosis, severity prediction, and prognosis assessment of AP through complementary advantages.

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Section: Amas and The Theory Of Antigenic Mimicrymentioning

confidence: 99%

New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage

Reshetnyak,

Maev

2023

World J Gastroenterol

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To the 90th anniversary of the Department of Epidemiology and Evidence-based Medicine of the Sechenov University: from history to the present

Брико¹,

Mindlina²,

Полибин³

et al. 2022

Profil. med.

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Etiology of acute intestinal infections of viral character in the Altai territory

Nikonorova

Карбышева

Shevtsova

et al. 2021

Epidemiology and Infectious Diseases

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Background: The incidence of acute intestinal infections (ACI) remains at a high level every where, despite the ongoing medical and sanitary preventive measures. The significant progress made in the field of laboratory diagnostics allowed us to proceed to a detailed study of the etiological structure of AСI and as a result, it was found that in recent years the role of pathogens of viral nature has significantly increased, but a detailed study and characterization of these pathogens requires further research. Aims: to study the etiological structure and clinical and laboratory features of acute intestinal infections of viral etiology in adult patients in an infectious hospital. Materials and methods: The study included 181 patients, aged 18 to 76 years, who were on inpatient treatment in infectious diseases of "City hospital No. 5, Barnaul". The method of polymerase chain reaction (PCR) with hybridization-fluorescence detection "AmpliSens OKI screen-FL", bacteriological and serological (RIHA) methods were used for the diagnosis of acute intestinal infections. Results: In 108 patients (59.7%), the genetic materials of various pathogens of acute intestinal infections were detected. Of these, 54 (29.8%) patients had acute intestinal infection of viral etiology, including mono-infection in 45 people (83.3%) and caused by a combination of two viruses 9 people (16.7%); 41 (22.7%) patients had bacterial etiology, including a combination of two pathogens in 4 cases (2.2%) and 1 case with three pathogens; 13 patients with a combined viral bacterial intestinal infection and, in 73 patients the etiology was not established. The paper presents the epidemiological and clinical and laboratory features of acute intestinal infections of viral etiology. Conclusion: The data obtained indicate a trend in changes in the structure of acute intestinal infections, characterized by an increase in the proportion of viral intestinal infections (up to 50% in this study), which affects the choice of etiotropic and pathogenetic therapy. The results obtained demonstrate the effectiveness of the PCR method in the diagnosis of acute intestinal infections.

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Epidemiological characteristics of most relevant digestive system diseases of infectious nature in the regions of Russia

Cited by 7 publications

References 7 publications

New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage

New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage

To the 90th anniversary of the Department of Epidemiology and Evidence-based Medicine of the Sechenov University: from history to the present

Etiology of acute intestinal infections of viral character in the Altai territory

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