Epidemiological Characteristics of the Largest Kidney Transplant Program in Mexico: Western National Medical Center, Mexican Institute of Social Security

Solis-Vargas, E.; Evangelista-Carrillo, Luis Alberto; Puentes-Camacho, Abel; Rojas–Campos, Enrique; Andrade‐Sierra, Jorge; Cerrillos‐Gutiérrez, José Ignacio; Nieves-Hernández, J.J.; Jalomo-Martínez, Basilio; Medina-Pérez, Miguel; Martínez-Martínez, Petra; Monteón-Ramos, Francisco; Gómez-Navarro, Benjamín

doi:10.1016/j.transproceed.2016.03.039

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…In our study as in our setting, male receptors are 3 : 1 compared to female [10, 23]; this is due to social and epidemiological conditions; perhaps our results show that AGD was most commonly presented in males; all AGD in the period of time were included; nevertheless gender was associated to it presence; due to the fact that all patients have the same immunosuppressive scheme it is possible that this finding was gender-related. Other studies have shown significant correlation in OS in males compared to females although the gender was not a condition to differentiate OS levels (AGD more frequent in men).…”

Section: Discussionmentioning

confidence: 50%

The Oxidative and Inflammatory State in Patients with Acute Renal Graft Dysfunction Treated with Tacrolimus

Carrillo-Ibarra

Cerrillos‐Gutiérrez

Escalante-Núñez

et al. 2016

Oxidative Medicine and Cellular Longevity

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Objective. To determine the oxidative stress/inflammation behavior in patients with/without acute graft dysfunction (AGD) with Tacrolimus. Methods. Cross-sectional study, in renal transplant (RT) recipients (1-yr follow-up). Patients with AGD and without AGD were included. Serum IL-6, TNF-α, 8-isoprostanes (8-IP), and Nitric Oxide (NO) were determined by ELISA; C-reactive protein (CRP) was determined by nephelometry; lipid peroxidation products (LPO) and superoxide dismutase (SOD) were determined by colorimetry. Results. The AGD presentation was at 5.09 ± 3.07 versus 8.27 ± 3.78 months (p < 0.001); CRP >3.19 mg/L was found in 21 versus 19 in the N-AGD group (p = 0.83); TNF-α 145.53 ± 18.87 pg/mL versus 125.54 ± 15.92 pg/mL in N-AGD (p = 0.64); IL-6 2110.69 ± 350.97 pg/mL versus 1933.42 ± 235.38 pg/mL in N-AGD (p = 0.13). The LPO were higher in AGD (p = 0.014): 4.10 ± 0.69 µM versus 2.41 ± 0.29 µM; also levels of 8-IP were higher in AGD 27.47 ± 9.28 pg/mL versus 8.64 ± 1.54 pg/mL (p = 0.01). Serum levels of NO in AGD were lower 138.44 ± 19.20 µmol/L versus 190.57 ± 22.04 µmol/L in N-AGD (p = 0.042); antioxidant enzyme SOD activity was significantly diminished in AGD with 9.75 ± 0.52 U/mL versus 11.69 ± 0.55 U/mL in N-AGD (p = 0.012). Discussion. Patients with RT present with a similar state of the proinflammatory cytokines whether or not they have AGD. The patients with AGD showed deregulation of the oxidative state with increased LPO and 8-IP and decreased NO and SOD.

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Section: Discussionmentioning

confidence: 50%

The Oxidative and Inflammatory State in Patients with Acute Renal Graft Dysfunction Treated with Tacrolimus

Carrillo-Ibarra

Cerrillos‐Gutiérrez

Escalante-Núñez

et al. 2016

Oxidative Medicine and Cellular Longevity

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“…Approximately 63% of those with end stage renal disease and on hemodialysis are due to T2DM. [11] In 2011, the total direct cost of diabetes to Mexico's health care system was estimated at 3.4 billion USD. [12] 1.2 Role of primary care in non-communicable disease screening and prevention Primary care provides a key role in the prevention, early detection and management of NCDs and associated risk factors.…”

Section: Burden Of T2dm In Mexicomentioning

confidence: 99%

Estimating risk and cost: An analysis of patients with risk factors for Type 2 Diabetes in rural Jalisco, Mexico

Morales

Hall²,

Harris³

et al. 2019

JNEP

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The global age standardized prevalence of type 2 diabetes (T2DM) has doubled (4.7% to 8.5%) over the last three decades and is increasing more rapidly in low and middle-income countries (LMICs). The global economic burden of diabetes affects individuals and health care systems and is estimated to cost $825 billion USD a year. Within Mexico, T2DM is the second leading cause of mortality and the leading cause of morbidity using disability associated life years (DALYs). A retrospective chart review and cost analysis, analyzing those at risk of diabetes, was conducted at a rural community health clinic in Jalisco, Mexico. The goal was to project the cost of providing an appropriate scope of care and plan prevention-based population health programs. The results demonstrated that out of 264 charts reviewed, 218 (83%) had one or more diabetic risk factor. The estimated per patient per visit cost is $127.22 MP (Mexican Peso, 2018) and as the number of diabetes risk factors increases for an individual patient, the mean cost of their care to the system increases (p < .001). Those with at least one risk factor comprise the majority in both males and females with a median age of 36 and median BMI of 28, and this group also has the highest percentage of borderline hypertension (46%). This data demonstrates an opportunity to intervene in a group of young adults (ages 27-46) with a cluster of high-risk borderline risk factors and preventing them from developing obesity, hypertension and diabetes later in life.

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“…1 Debido a la gran penetración de los servicios de salud, el Instituto Mexicano del Seguro Social actualmente realiza el mayor número de trasplantes en el país, con resultados satisfactorios. 2 Sin embargo, la incidencia y prevalencia de la enfermedad renal crónica (ERC) incrementadas rebasan la capacidad resolutiva de la cirugía de TR. 3 El número de trasplantes en cada medición realizada resulta en un incremento; no obstante, de manera similar ocurre con el registro de pacientes con ERC que requieren de TR.…”

Section: Introductionunclassified

Comportamiento de la referencia a trasplante renal en el Instituto Mexicano del Seguro Social

Méndez-Durán¹

2020

Revista Mexicana De Trasplantes

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Introduction: The substitute therapies of the renal function constitute a support of life, nevertheless they are temporary treatments until realizing renal transplantation (TR), meanwhile the complications are present the deterioration of the quality and reduction of the life expectancy. The TR rehabilitates, gives the possibility of a normal life, family, social and labor reintegration. The reference to TR day by day becomes more frequent and knowing the behavior will allow to implement improvement strategies. Material and methods: Retrospective and cross-sectional study conducted from 2014 to 2019, includes data on references to TR generated by the general and regional hospitals of the IMSS of subjects up to 65 years of age. Reference location is identified, gender, age, cause of chronic renal failure (CRF), modality of replacement therapy. Results: 19,979 patients were referred, 12,386 were male (62%) and 7,593 female (38%), aged 1 to 65 years, the group of 20 to 29 years was the most prevalent (30%). The highest number of references received peritoneal dialysis 9,166 (46%), hemodialysis 8,981 (45%), and 1,832 (9%) pre-dialysis. The reference increased 8.7% annual average in all the dialysis modalities. Conclusions: The reference presents a continuous increase and pre-dialysis patients each year are referred in greater numbers. The demand for renal transplantation exceeds the needs of the institution and offers a large area of opportunity to favor a greater number of patients.

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Epidemiological Characteristics of the Largest Kidney Transplant Program in Mexico: Western National Medical Center, Mexican Institute of Social Security

Cited by 4 publications

References 9 publications

The Oxidative and Inflammatory State in Patients with Acute Renal Graft Dysfunction Treated with Tacrolimus

The Oxidative and Inflammatory State in Patients with Acute Renal Graft Dysfunction Treated with Tacrolimus

Estimating risk and cost: An analysis of patients with risk factors for Type 2 Diabetes in rural Jalisco, Mexico

Comportamiento de la referencia a trasplante renal en el Instituto Mexicano del Seguro Social

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