Epidemiological Data of Different Human Papillomavirus Genotypes in Cervical Specimens of HIV-1-Infected Women Without History of Cervical Pathology

Videla, Sebastián; Darwich, Laila; Cañadas, Maria Paz; Paredes, Roger; Tarrats, Antoni; Castellà, Eva; Llatjós, Mariona; Bofill, Margarita; Clotet, Bonaventura; Sirera, Guillem

doi:10.1097/qai.0b013e3181938e63

Cited by 30 publications

(33 citation statements)

References 43 publications

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“…3,9 In the HIV-free population, the rate of HPV infection is highest in women below 30 years of age and decreases at older ages. Such a decrease in prevalence in older women was not observed in our study population of women positive for HIV, with around 50% of women being infected with HR-HPV.…”

Section: Rate Of Cin2+ (95% Ci)mentioning

confidence: 99%

Characteristics of HPV infection over time in European women who are HIV‐1 positive

Heard

Cubie

Mesher

et al. 2012

BJOG

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Objective The objectives of the study were to investigate high-risk human papillomavirus (HR-HPV) infection and type distribution in women infected with HIV-1, and to determine the relevance of HR-HPV positivity and persistence/loss to the development of high-grade cervical disease.Design A total of 518 European women infected with HIV attending for routine gynaecological care consented to 6-monthly follow-up visits over 3 years, with surveillance of cytology, colposcopy and histopathology, where relevant, and longer follow-up, where possible.Setting European women infected with HIV attending for routine gynaecological care.Population or sample 518 European women infected with HIV attending for gynaecological care in 6 hospital-based European centres -Dublin, Edinburgh, London, Milan, Paris, and Warsaw.Methods Cervical screening was achieved by liquid-based cytology (LBC) of brush samples in PreservCytÒ medium. The HPV testing of residual samples was performed by Hybrid-Capture II, with genotyping of positives using the HPV Line Blot Assay. Histology results were accessed where available.Main outcome measures Description of high risk human papillomavirus (HR-HPV) infection and type distribution in HIV-1 infected women. ResultsThe estimated prevalence at baseline of any HR-HPV type was 49.5% (46.3-52.8%): 10.2% for HPV 16 and 4.3% for HPV 18. The prevalence increased with increasing immunosuppression. Multiple infections were detected in 26.8%. HR-HPV genotypes were detected in 34.9% of cases with normal cytology, in 77.2% of cases with atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesion (ASCUS/LSIL) and in 90.8% of cases with high-grade SIL (HSIL). The prevalence of HPV 16 in HSIL was 38.5%, with the three most common types thereafter having prevalence rates of 19.2% (HPV 58), 19.2% (HPV 53) and 16.6% (HPV 52). The overall persistence of any high-risk type was 55.8%. We found that 6 months persistence of HPV 16 occurred in 24 women. Seven cases of high-grade cervical disease developed, and all were associated with initial/persistent HR-HPV positivity.Conclusions A wide diversity of HPV types was evident, and multiple infections were common. Detection or persistence of any HR-HPV was associated with a very low incidence of subsequent high-grade disease.

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Section: Rate Of Cin2+ (95% Ci)mentioning

confidence: 99%

Characteristics of HPV infection over time in European women who are HIV‐1 positive

Heard

Cubie

Mesher

et al. 2012

BJOG

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“…Existe una gran prevalencia de VPH-AR en estas poblaciones (con frecuencia superior al 30%) y una elevada proporción de alteraciones citológicas [131][132][133] . Estos datos han fundamentado el cribado con citología repetida a intervalos de 1 año 134 .…”

Section: Justificaciónunclassified

Guía de cribado del cáncer de cuello de útero en España, 2014

Bladé

Saladrigues

Gimferrer³

et al. 2014

Progresos de Obstetricia y Ginecología

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Justificación de la Guía de cribado del cáncer de cuello de útero en España, 2014El cáncer de cuello uterino (CCU) es la tercera neoplasia más frecuente en el mundo en las mujeres. El cribado de mujeres sanas mediante citología cervical ha demostrado claramente su eficacia, puesto que su aplicación de forma adecuada y sistemática en determinados paí-ses ha conseguido reducir en un 70-80% la incidencia y mortalidad por CCU. Este beneficio se debe a la detección de lesiones premalignas asintomáticas cuyo diagnóstico y tratamiento evita su progresión a carcinoma invasor.En las dos últimas décadas, múltiples estudios han aportado una só-lida evidencia que confirma al virus del papiloma humano (VPH) como agente causal de la práctica totalidad de los casos de CCU y de sus lesiones precursoras. Un número limitado de genotipos de VPH de alto riesgo oncogénico (VPH-AR) está causalmente implicado. Concretamente, los VPH 16 y 18 explican el 70% de los CCU y otros 10 tipos (VPH 45,31,33,52,58,35,59, 56, 51 y 39) explican el 25-35% de los casos restantes. Esta información ha permitido establecer un nuevo modelo de carcinogénesis basado en la persistencia de la infección por VPH como elemento necesario para el desarrollo de lesiones precursoras y CCU. Sin embargo, más del 90% de las infecciones por VPH son transitorias y, por tanto, irrelevantes desde el punto de vista oncogénico. Durante los primeros años de vida sexual se observa una elevada incidencia de infección, pero la mayoría de estas infecciones son transitorias y desaparecen espontáneamente. Las mujeres mayores de 30 años experimentan una clara disminución de la prevalencia de la infección por VPH, pero un

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“…), followed by heat inactivation at 95°C for 10 minutes and kept frozen until PCR. HPV was detected and typed using the F-HPV typing™ kit (Molgentix, Spain) for HPV 6,11,16,18,31,33,35,39,45,51,52,56,58,59, and 68 as previously described 25 .…”

Section: Dna Extraction and Hpv Genotypingmentioning

confidence: 99%

“…This sample was used for cytology and DNA extraction. Anal canal and oral epithelial cell samples were obtained as previously described [25].…”

Section: Sample Collectionmentioning

confidence: 99%

Human papillomavirus infection and associated lesions in the cervix, anal canal, and mouth of HIV-uninfected women with different HIV risk status in Barcelona

Darwich¹,

Videla²,

Ornelas³

et al. 2017

Virol Res Rev

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Objective: Data on human papillomavirus (HPV) infections and their related lesions appearing simultaneously at different anatomical sites are scarce. Our aim was to provide information about HPV infection and lesions of the cervix, anal canal, and mouth of women at different risk conditions to be infected by HIV. Methods:Cross-sectional study. Detection and genotyping of HPV infections were done by multiplex PCR, and the cytology by Papanicolaou test. HPV Prevalence and associated risk factors were estimated. Results:The study included 108 women (44 at risk and 64 with no risk of HIV-infection). The highest prevalence of HPV infection was found in the anal canal (26% at HIV-risk versus 28% with no risk group, p=0.79), followed by the cervix (14% versus 28%, p=0.07) and the oral cavity (7% versus 9%, p=0.64). HPV16 was the most prevalent type in cervix (5.6%) and anus (8.6%) for both groups but HPV52 (4.5%) was the most frequent type in the mouth of the at-risk group. Interestingly, women from the at HIV-risk group presented higher prevalence of anal infection involving a wider range of different high-risk oncogenic HPV-types. Concomitant HPV infections with HPV16, 18 and other oncogenic types (HPV56, 59) were found in 3.1% of women (all three areas) and 7.1% (cervix and anal canal). As regards HPV-related lesions, no statistical differences were observed between groups, although women at HIV-risk had higher proportion of anal abnormalities (18.4% versus 8.2%, p=0.19). Finally, cervical HPV-infection was significantly associated with presence of cervical or anal condylomata and alcohol consumption and anal HPV-infection with smoking and RAI. Conclusion:Both women at risk of HIV-infection or with anogenital warts presented a wider range of HPV-oncogenic types in the anal canal, resulting good candidates for HPV anal screening and monitoring programs.

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Epidemiological Data of Different Human Papillomavirus Genotypes in Cervical Specimens of HIV-1-Infected Women Without History of Cervical Pathology

Abstract: HPV infection is highly prevalent and persistent among HIV-1-infected women with normal Papanicolau smears. HR-HPV genotypes other than HPV-16 (HPV-33, HPV-52) are frequently detected in HIV-infected women. mPCR provides better surveillance of HPV infection than HC-2 methods.

Cited by 30 publications

References 43 publications

Characteristics of HPV infection over time in European women who are HIV‐1 positive

Characteristics of HPV infection over time in European women who are HIV‐1 positive

Guía de cribado del cáncer de cuello de útero en España, 2014

Human papillomavirus infection and associated lesions in the cervix, anal canal, and mouth of HIV-uninfected women with different HIV risk status in Barcelona

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