Epidemiological Features for Primary Lymphoma of the Female Genital Tract Patients and Development of a Nomogram to Predict Survival

Abstract

Background: Primary lymphoma of the female genital tract (PLFGT) is a sporadic extranodal lymphoma. Its epidemiology and prognosis are not fully recognised. Our study aimed to construct and validate prognostic nomograms for predicting survival for patients with PLFGT.Methods: Incidence rate from 1975 to 2017 and patients with PLFGT from 1975 to 2011 in the Surveillance, Epidemiology and End Results (SEER) database were retrospectively reviewed. The nomograms of OS and DSS were established according to the multivariate Cox regression analyses. The concordance index (C-index) and calibration plots were used to demonstrate its robustness and accuracy.Results: A total of 617 PLFGT patients were identified. The overall incidence of PLFGT is 0.44/1,000,000 (adjusted to the US standard population in 2000) from 1975 to 2017. Age, histological subtype, Ann Arbor Stage, and therapeutic strategy were identified as independent prognostic factors for overall survival (OS) and disease-specific survival (DSS) by multivariate Cox regression (P < 0.05). Nomograms to predict 1-, 5-, and 10- year OS and DSS were established. The C-index and calibration plots showed a good discriminative ability and an optimal accuracy of the nomograms. Patients were devided into three risk groups according to the model of OS.Conclusions: The nomograms were developed and validated as an individualized tool to predict OS and DSS.