Epidemiological investigation after hospitalising a case with pandrug-resistant Acinetobacter baumannii infection

Chuang, Yu-Chun; Huang, Yhu-Chering; Lin, Cheng‐Han; Su, Lin‐Hui; Wu, Chieh‐Tsai

doi:10.1016/j.jhin.2009.02.003

Cited by 10 publications

(6 citation statements)

References 26 publications

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“…Moreover, pandrug-resistant A. baumannii isolates (resistant to all available class of antibiotics) have also been increasingly identified in Asia. 4,16 This highlights the increasing trend of antibiotic resistance in A. baumannii in the APAC region, especially resistance to carbapenems.…”

Section: Introductionmentioning

confidence: 93%

Molecular Epidemiology and Mechanisms of Carbapenem Resistance ofAcinetobacterspp. in Asia and Oceania

Kamolvit

Sidjabat

Paterson

2015

Microbial Drug Resistance

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Acinetobacter baumannii is emerging as a pathogen that is commonly involved in nosocomial infections. A. baumannii has exhibited the ability to develop multidrug resistance (MDR), including resistance to carbapenems, the last-line class of antibiotics to treat these infections. In particular, MDR A. baumannii International Clone (IC) 2 has disseminated worldwide causing substantial problems in hospitals, including in Asia and Oceania. The global spread of this clonal lineage emphasizes the importance of tracking molecular epidemiology to obtain greater understanding of the population dynamics of A. baumannii. Carbapenem resistance in A. baumannii occurs mainly as a result of acquisition of OXA-type carbapenemase genes, and to some extent by acquisition of metallo-β-lactamase genes. The acquisition of carbapenemase genes, particularly the bla(OXA-23), bla(OXA-40), and bla(OXA-58), by specific clonal lineages may be one of the attributes responsible for the relative homogeneity of the MDR A. baumannii population.

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Section: Introductionmentioning

confidence: 93%

Molecular Epidemiology and Mechanisms of Carbapenem Resistance ofAcinetobacterspp. in Asia and Oceania

Kamolvit

Sidjabat

Paterson

2015

Microbial Drug Resistance

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“…The most important mechanism, however, is the endless capacity of Acinetobacter species to acquire antibiotic resistance, leading to MDR and even PDR 12. There are many mechanisms of antibiotic resistance; here we discuss only resistance to carbapenem and colistin.…”

Section: Resistance Mechanismsmentioning

confidence: 99%

Update on the Epidemiology, Treatment, and Outcomes of Carbapenem-resistantAcinetobacter infections

Kim

et al. 2014

Chonnam Med J

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Carbapenem-resistant Acinetobacter species are increasingly recognized as major nosocomial pathogens, especially in patients with critical illnesses or in intensive care. The ability of these organisms to accumulate diverse mechanisms of resistance limits the available therapeutic agents, makes the infection difficult to treat, and is associated with a greater risk of death. In this review, we provide an update on the epidemiology, resistance mechanisms, infection control measures, treatment, and outcomes of carbapenem-resistant Acinetobacter infections.

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“…Nosocomial infection is a fatal threat to babies in NICU, 17,18 most of these infections take place in one ward. Ward‐to‐ward cross‐infection, such as NICU infection transmitted from adult wards, has not been widely reported.…”

Section: Discussionmentioning

confidence: 99%

Clinical and molecular microbiological characteristics of carbapenem‐resistant Acinetobacter baumannii strains in an NICU

Hu¹,

Wang

Ding

et al. 2011

Pediatrics International

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Epidemiological investigation after hospitalising a case with pandrug-resistant Acinetobacter baumannii infection

Cited by 10 publications

References 26 publications

Molecular Epidemiology and Mechanisms of Carbapenem Resistance ofAcinetobacterspp. in Asia and Oceania

Molecular Epidemiology and Mechanisms of Carbapenem Resistance ofAcinetobacterspp. in Asia and Oceania

Update on the Epidemiology, Treatment, and Outcomes of Carbapenem-resistantAcinetobacter infections

Clinical and molecular microbiological characteristics of carbapenem‐resistant Acinetobacter baumannii strains in an NICU

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