Epidemiological, Mitigation and Economic Impact of Zoonoses

Conrady, Beate

doi:10.3390/ijerph182111704

Cited by 1 publication

(1 citation statement)

References 22 publications

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“…32 To date, more than 200 zoonoses have been identified in humans. 33 Large-scale zoonotic outbreaks pose a serious threat to public health worldwide with negative impacts on the global economy and sustainable development, such as the H1N1 influenza pandemic (2009), the West African Ebola virus disease (EVD) epidemic (2013-2016), the Congo EVD epidemic (2018-2020), and coronavirus disease 2019 (COVID-19). 34 With the advantages of high sensitivity, rapid response, and on-site detection of RPA, accurate screening assays can be useful tools for rapidly controlling the spread of zoonotic epidemics.…”

Section: Application Of the Rpa Biosensor In The Detection Of Zoonoti...mentioning

confidence: 99%

Recombinase Polymerase Amplification-Based Biosensors for Rapid Zoonoses Screening

Feng,

Liu,

Zhao

et al. 2023

IJN

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Recent, outbreaks of new emergency zoonotic diseases have prompted an urgent need to develop fast, accurate, and portable screening assays for pathogen infections. Recombinase polymerase amplification (RPA) is sensitive and specific and can be conducted at a constant low temperature with a short response time, making it especially suitable for on-site screening and making it a powerful tool for preventing or controlling the spread of zoonoses. This review summarizes the design principles of RPA-based biosensors as well as various signal output or readout technologies involved in fluorescence detection, lateral flow assays, enzymatic catalytic reactions, spectroscopic techniques, electrochemical techniques, chemiluminescence, nanopore sequencing technologies, microfluidic digital RPA, and clustered regularly interspaced short palindromic repeats/CRISPR-associated systems. The current status and prospects of the application of RPA-based biosensors in zoonoses screening are highlighted. RPA-based biosensors demonstrate the advantages of rapid response, easy-to-read result output, and easy implementation for on-site detection, enabling development toward greater portability, automation, and miniaturization. Although there are still problems such as high cost with unstable signal output, RPA-based biosensors are increasingly becoming one of the most important means of on-site pathogen screening in complex samples involving environmental, water, food, animal, and human samples for controlling the spread of zoonotic diseases.

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Section: Application Of the Rpa Biosensor In The Detection Of Zoonoti...mentioning

confidence: 99%

Recombinase Polymerase Amplification-Based Biosensors for Rapid Zoonoses Screening

Feng,

Liu,

Zhao

et al. 2023

IJN

View full text Add to dashboard Cite

show abstract

Epidemiological, Mitigation and Economic Impact of Zoonoses

Abstract: There is increasing evidence on the negative impacts of animal diseases on global productivity [...]

Cited by 1 publication

References 22 publications

Recombinase Polymerase Amplification-Based Biosensors for Rapid Zoonoses Screening

Recombinase Polymerase Amplification-Based Biosensors for Rapid Zoonoses Screening

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