Epidemiology and antimicrobial resistance profile of Neisseria gonorrhoeae in Catalonia, Spain, 2016–2019

Herrero, Mercè; Broner, Sonia; Cruells, Adrià; Esteve, Silvia; Ferré, Lourdes; Mendioroz, Jacobo; Jané, Mireia; Ciruela, Pilar; ,; Benítez, Miguel Ángel; Bosch, Jordi; Pitart, Cristina; Ballester, Frederic; Calderón, Ana; Falgueras, Teresa; Martí, Carmina; Pulido, Mª Àngeles; Curriu, Margarida; Sanfeliu, Ester; Ayala, Percy Juan; Gallés, Carme; Capdevila, Elisenda; Hernández, Pilar; Gassiot, Paula; Mora, Carme; Gómez, Frederic; González, Araceli; Aixalà, Màrius Juanpere; Padilla, Eduardo; Gené, Amadeu; Navarro, Ferran; Rivera, Alba; Sánchez, Ferran; Trujillo, Gloria; López, Joan; Olsina, Montserrat; Pérez, Pepa; Pérez, Mar Olga; Ramírez, Joan Manel; Raga, Xavier; Lucena, Judith; Aramburu, Jesús; Riera, Esther Sanfeliu; Sauca, Goretti; Valle, Inés; Vilamala, Anna; Hoyos, Yannick; Cámara, Jordi; Niubó, Jordi; Rodríguez, Graciela; Tubau, Fe; Quesada, Maria Dolores; Torrellas, Nuria; Claver, Natàlia; Bastida, Teresa; Santos, Rosalia; González-Moreno, Olga

doi:10.1007/s10096-023-04601-0

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…In our study, all isolates of N. gonorrhoeae remained susceptible to ceftriaxone which is different from other reports that showed resistance from Thailand 17 and Spain. 33 Hence, high multidrug resistant isolates of N. gonorrhoeae were observed in the study area.…”

Section: Discussionmentioning

confidence: 88%

Prevalence, Antibiotic Resistance and Associated Factors of Neisseria gonorrhoeae Among Patients Attending Non-Profitable Private Clinics in Mekelle, Tigrai, Ethiopia

Kahsay¹,

Mezgebo²,

Gebrekidan³

et al. 2023

IDR

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Background Globally, Neisseria gonorrhoeae is the second most common cause of bacterial sexually transmitted diseases. The prominent predicament of this bacterium is its complications, non-susceptibility for many drugs, and aggravated transmission of other sexually transmitted infections. There is limited information about the prevalence, antibiotic resistance, and risk factors of N. gonorrhoeae in Tigrai, Ethiopia. Therefore, we aimed to determine the prevalence, antibiotic resistance, and risk factors of N. gonorrhoeae among patients attending non-profitable private clinics in Mekelle, Tigrai, Ethiopia. Methods A cross-sectional study among 229 patients was conducted from February to June 2018. The socio-demographic data and associated factors were gathered using structured questionnaire, and swabs were taken from urethra and cervix of males and females, respectively. Specimens were inoculated on standard bacteriological culture media and antibiotic susceptibility testing was performed using Kirby-Bauer disc diffusion technique following the Clinical and Laboratory Standard Institute. Data were analyzed using Statistical Package for Social Sciences Version 21. The level of significance at p-value <0.05 was considered statistically significant. Results The overall prevalence of N. gonorrhoeae was 23 (10.04%). High prevalence rates of N. gonorrhoeae were observed in females, urban residents and married ones. N. gonorrhoeae had shown statistically significant association with HIV positive, previous history of STIs, shisha users, Khat ( Catha edulis ) users, condom non-users and having more than two sexual partners. All isolates showed resistance to penicillin followed by tetracycline 16 (69.6%) and ciprofloxacin 8 (34.8%). Four isolates (7.4%) exhibited resistance to azithromycin with no resistance to ceftriaxone. Twelve (52.2%) isolates showed multidrug resistance (MDR). Conclusions The prevalence of N. gonorrhoeae and drug resistance, including multidrug resistance, was high in the study. Multiple factors were associated with the acquisition of N. gonorrhoeae . Therefore, behavioral change and communication should be strengthened.

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Section: Discussionmentioning

confidence: 88%

Prevalence, Antibiotic Resistance and Associated Factors of Neisseria gonorrhoeae Among Patients Attending Non-Profitable Private Clinics in Mekelle, Tigrai, Ethiopia

Kahsay¹,

Mezgebo²,

Gebrekidan³

et al. 2023

IDR

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“…Referring to Italy in 2018, the surveillance system found <0.1% of Ng with CRO-R/DS, 5% to 29.9% with AZM-R, and 30% to 69.9% with CIP-R 7,8 . Focusing on the European region, previous studies suggested an increase in azithromycin resistance, with very limited cases of ceftriaxone resistance 9–11 . Limited data on Ng antimicrobial resistance profile in Italy over the years are available.…”

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confidence: 99%

Trends of Antimicrobial Susceptibility of Neisseria gonorrhoeae Isolates Between 2012 and 2023: Results From an Open Italian Cohort

Lucente,

Raccagni,

Galli

et al. 2024

Sexual Trans Dis

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Background Neisseria gonorrhoeae (Ng) is a public health priority due to the rapid evolution of antimicrobial resistance, the emergence of antibiotic resistance and the absence of a vaccine against Ng. The aim of this study was to investigate trends in the minimum inhibitory concentration (MIC) and resistance (R) or reduced susceptibility (DS) of Ng cases to ceftriaxone (CRO), azithromycin (AZM), tetracycline (TET), benzylpenicillin (PenG), ciprofloxacin (CIP) over a 10-year period. Methods Retrospective analysis on an open cohort of Ng cases diagnosed on rectal, urethral and pharyngeal samples at San Raffaele Scientific Institute, between September 2012-February 2023. MICs of antibiotics were determined by gradient-test strips. Bivariate linear regression models, applied on logarithmic MICs values; Cochran-Armitage test was used to determine a linear trend in the proportions of resistant strains. Results 436 Ng isolates from 352 individuals were analyzed. MICs of CRO and PenG reduced over time (p < 0.001, p = 0.030), AZM increased (p = 0.001), CIP and TET did not change (p = 0.473, p = 0.272). The percentages of resistant strains were: PenG 89.9%, TET 90.8%, CIP 48.2%, AZM 4.4%; CRO-DS strains were 8.7%, only one CRO-R. The proportion of resistant strains increased over time for AZM (p = 0.007), TET (p = 0.001), CIP (p < 0.001), whereas decreased for PenG (p < 0.001) and CRO-DS/R strains (p < 0.001). Conclusions Ng strains showed high susceptibility to CRO, although we identified cases of DS/R and observed high levels of susceptibility to AZM. Overall, the recommended primary regimen for Ng treatment confirmed to be effective.

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Screening for STIs: Results of a Health-Promotion Programme in a Portuguese University

Oliveira,

Martins,

Veiga

et al. 2024

Microorganisms

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Sexually Transmitted Infections (STIs) are an important and growing public health concern. Implementation of screening programmes and awareness campaigns are crucial to mitigate this problem. A university in the central region of Portugal has devised a health-promotion programme, named Protection+, specifically directed towards the sexual health of the university community. The present study aimed to evaluate the results of the different actions undertaken as part of the health-promotion programme during the 2023–2024 academic year. Chlamydia, gonorrhoea, trichomoniasis and infection with Mycoplasma genitalium were assessed through real-time polymerase chain reaction protocols. Syphilis, infection with HIV, HBV and HCV were assessed through immunological assays. The adherence to the health-promotion programme after the awareness campaigns was also evaluated. STIs have been diagnosed in 13.7% of the 475 screened participants. Chlamydia was the STI most frequently diagnosed (8.4%), followed by infection with M. genitalium (2.3%), T. pallidum (2.0%) and N. gonorrhoeae (1.1%). HIV, HBV and HCV were diagnosed in a residual number of cases, and T. vaginalis was not detected in any of the screened participants. At the time of diagnosis, more than half of the infected patients were asymptomatic. After the implementation of awareness campaigns, an increase in the adherence to STI screening was observed, with the expected simultaneous increase in STI diagnoses. The high prevalence of STIs, particularly chlamydia, in the university population, along with the asymptomatic nature of these infections, demonstrated the importance of STI screenings and the implementation of campaigns that raise awareness on the prevention and consequences of untreated STIs.

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Epidemiology and antimicrobial resistance profile of Neisseria gonorrhoeae in Catalonia, Spain, 2016–2019

Cited by 3 publications

References 23 publications

Prevalence, Antibiotic Resistance and Associated Factors of Neisseria gonorrhoeae Among Patients Attending Non-Profitable Private Clinics in Mekelle, Tigrai, Ethiopia

Prevalence, Antibiotic Resistance and Associated Factors of Neisseria gonorrhoeae Among Patients Attending Non-Profitable Private Clinics in Mekelle, Tigrai, Ethiopia

Trends of Antimicrobial Susceptibility of Neisseria gonorrhoeae Isolates Between 2012 and 2023: Results From an Open Italian Cohort

Screening for STIs: Results of a Health-Promotion Programme in a Portuguese University

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