Epidemiology, Evolution, and Long‐Term Survival of Alcoholic Cirrhosis Patients Submitted to Liver Transplantation in Southeastern <scp>S</scp>pain

Legáz, Isabel; Navarro-Noguera, Elena; Bolarín, José Miguel; García‐Alonso, Ana M.; Maldonado, Aurelio Luna; Mrowiec, Anna; Campillo, José A.; Gimeno, Lourdes; Moya-Quiles, Rosa; Álvarez-López, Maria del Rocio; Minguela, Alfredo; Miras, M.; Sánchez‐Bueno, Francisco; Muro, Manuel

doi:10.1111/acer.13013

Cited by 28 publications

(32 citation statements)

References 44 publications

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“…In the present study, male AC patients who underwent LT had a mean age of 54 years. Similar data were observed in other studies on different populations and periods of time [47][48][49]. It should be noted that slight differences with respect to this mean age have been described in other studies, suggesting a significant correlation between ethnicity and age of cirrhosis diagnosis, and the possibility of an ethnic and/or genetic basis for cirrhosis [50].…”

Section: Discussionsupporting

confidence: 90%

“…It is well established that chronic alcohol drinking is the main cause of liver fibrosis, which is accelerated in patients with viral infection [9,11,13,14]. After chronic liver injury, hepatocyte damage and activated Kupffer cells lead to the activation of hepatic stellate cells (HSC), producing a large amount of ECM, which are accumulated within the subendothelial space of Disse, and generate liver fibrosis [26,46].…”

Section: Discussionmentioning

confidence: 99%

“…A cohort of 281 male AC patients undergoing LT, recruited between 1990 and 2013, was analysed retrospectively. The clinical and biochemical characteristics and short-and long-term survival of the same cohort of AC patients have been published previously [9,11]. In this study, the AC patients were divided into two age groups and receiver operation characteristic (ROC) curves were used to find an optimal cut-off value categorizing it into young and old groups.…”

Section: Studied Populationsmentioning

confidence: 99%

“…Alcoholism is a major socio-economic and medical problem worldwide, and a major risk factor for chronic liver disease, which includes 2 Arch Med Sci fatty liver, alcoholic hepatitis, fibrosis, cirrhosis and hepatocellular carcinoma [1][2][3][4][5][6]. Alcoholic cirrhosis (AC) is the most common indication for liver transplantation (LT), which accounts for approximately 33% of all primary transplants in Europe [7][8][9][10][11]. However, the molecular and cellular mechanisms underlying alcoholic liver fibrosis and its end-stage consequence, cirrhosis, are not completely understood [12][13][14][15], although it is generally believed that many factors and different types of cells interact in their development [16,17].…”

Section: Introductionmentioning

confidence: 99%

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KIR2DL2/S2 and KIR2DS5 in alcoholic cirrhotic patients undergoing liver transplantation

et al. 2021

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Introduction: The molecular mechanisms underlying alcoholic liver fibrosis and cirrhosis are not completely understood. Hepatic fibrosis involves the interplay of diverse cells and factors, including hepatic stellate cells (HSCs), Kupffer, NK cells, and T-lymphocyte subsets. Killer-cell immunoglobulin-like receptors (KIR) are membrane receptors involved in mediation between NK and activated HSCs, regulating NK cell function through their interaction with HLA-I molecules. The aim of this study was to analyse the genetic association between KIR genes and the susceptibility to or protection from alcoholic cirrhosis (AC) in a cohort of male AC patients undergoing liver transplantation (LT) with and without concomitant viral infections. Material and methods: KIR genotyping was performed in nuclear DNA extracted from 281 AC patients and compared with 319 male controls. Results: Significant differences between total AC patients and healthy controls were only found in the case of KIR2DL2 and KIR2DS5. KIR2DL2 was significantly underrepresented in non-viral AC patients (52.6% vs. 63.3%; p = 0.015), while patients heterozygous for KIR2DL2 were also underrepresented in the non-viral AC group compared with controls (p = 0.034). KIR2DS5 was overrepresented in this group compared with healthy controls (p = 0.002). All these observations were only evident in AC patients older than 54 years old. Conclusions: Our data suggest a contrary effect of KIR2DL2 and KIR2DS5 in AC patients older than 54 years, in whom the presence of KIR2DL2 appears to be protective against AC, whereas the presence of KIR2DS5 seems to promote the fibrotic process, particularly in patients with no associated viral infection.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Studied Populationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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KIR2DL2/S2 and KIR2DS5 in alcoholic cirrhotic patients undergoing liver transplantation

et al. 2021

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“…(Table 1). HCV and HBV pre-infection diagnosis was determined as described somewhere else [25]. N, number of individuals with a particular disease, AC, alcoholic cirrhosis; CIT, Cold ischemia time.…”

Section: Diagnostic Criteria Of Liver Transplant Indicationsmentioning

confidence: 99%

Influence of Preformed Antibodies in Liver Transplantation

Legáz

Boix

López

et al. 2020

JCM

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The significance of human leukocyte antigen (HLA) matching and preformed donor-specific antibodies (DSAs) in liver transplantation remains unclear. The aim of this study was to analyze the presence of DSAs in a large cohort of 810 liver recipients undergoing liver transplant to determine the influence on acute (AR) or chronic liver rejection (CR), graft loss and allograft survival. DSAs were identified using complement dependent cytotoxicity crossmatch (CDC-CM) and multiplexed solid-phase-based flow cytometry assay (Luminex). CDC-CM showed that a 3.2% of liver transplants were positive (+CDC-CM) with an AR frequency of 19.2% which was not different from that observed in negative patients (−CDC-CM, 22.3%). Only two patients transplanted with +CDC-CM (7.6%) developed CR and suffered re-transplant. +CDC-CM patients showed a significantly lower survival rate compared to −CDC-CM patients (23.1% vs. 59.1%, p = 0.0003), developing allograft failure within the first three months (p < 0.00001). In conclusion, we have demonstrated a relationship between the presence of preformed DSAs and the low graft liver survival, indicating the important role and the potential interest of performing this analysis before liver transplantation. Our results could help to detect patients with an increased risk of graft loss, a better choice of liver receptors as well as the establishment of individualized immunosuppressive regimens.

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Alcohol-related liver disease: Clinical practice guidelines by the Latin American Association for the Study of the Liver (ALEH)

Arab

Roblero

Altamirano

et al. 2019

Annals of Hepatology

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Epidemiology, Evolution, and Long‐Term Survival of Alcoholic Cirrhosis Patients Submitted to Liver Transplantation in Southeastern Spain

Cited by 28 publications

References 44 publications

KIR2DL2/S2 and KIR2DS5 in alcoholic cirrhotic patients undergoing liver transplantation

KIR2DL2/S2 and KIR2DS5 in alcoholic cirrhotic patients undergoing liver transplantation

Influence of Preformed Antibodies in Liver Transplantation

Alcohol-related liver disease: Clinical practice guidelines by the Latin American Association for the Study of the Liver (ALEH)

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