Epidemiology of Klebsiella bacteraemia: a case control study using Escherichia coli bacteraemia as control

Hansen, Dennis Schrøder; Gottschau, Adam; Kolmos, Hans Jørn

doi:10.1016/s0195-6701(98)90065-2

Cited by 93 publications

(79 citation statements)

References 36 publications

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“…The two clinically relevant species, K. pneumoniae and K. oxytoca was differentiated by the ability to produce indole from tryptophan (21). Majority of the isolates in the present study proved to be K. pneumoniae (90%) which is in good agreement with previous studies (12,38). For both organisms, however, prevalence was higher in males than in the female samples.…”

Section: Discussionsupporting

confidence: 93%

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Prevalence, antibiotic susceptibility profiles and ESBL production in Klebsiella pneumoniae and Klebsiella oxytoca among hospitalized patients

Chakraborty

Mohsina

Sarker³

et al. 2016

Period Biol

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Background and Purpose: Klebsiella pneumoniae and Klebsiella oxytoca are the two most common pathogens causing nosocomial infections in humans and are of great concern for developing multidrug resistance. In the present study, K. pneumoniae and K. oxytoca from clinical samples were evaluated for their antibiotic sensitivity patterns against commonly used antibiotics and production of extended-spectrum beta-lactamase (ESBL). Ampicillin, Amoxicillin, Ceftriaxone, Ciprofloxacin, Gentamicin, Nalidixic acid, Tetracycline was 100%, 90%, 45%, 40%, 45%, 25%, 50%, 35% respectively. Multidrug resistance was found more common in K. pneumoniae (56%) than in K. oxytoca (50%). Prevalence rate of ESBL producing Klebsiella was found 45% among which K. pneumoniae (50%) were found more prominent than K. oxytoca (25%). All the ESBL producing Klebsiella isolates were found to be multidrug resistant, showing 100% resistance to Ampicillin, Amoxicillin, Ceftriaxone and Ciprofloxacin. Materials and Methods:

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Section: Discussionsupporting

confidence: 93%

“…The leading Klebsiella species giving rise to infections in humans are Klebsiella pneumoniae and Klebsiella oxytoca (13). K. pneumoniae accounts for 75% to 86% of all Klebsiella species reported while Klebsiella oxytoca accounts for 13% to 25% of isolates (12,38).…”

Section: Introductionmentioning

confidence: 99%

Prevalence, antibiotic susceptibility profiles and ESBL production in Klebsiella pneumoniae and Klebsiella oxytoca among hospitalized patients

Chakraborty

Mohsina

Sarker³

et al. 2016

Period Biol

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“…However our study did not revealed the differences among diabetic and non diabetic female patients. This differences might have been attributed to factors such as geographical variations, ethnicity of study participants and variation in the screening tests used [16,17].…”

Section: Discussionmentioning

confidence: 99%

Diabetes mellitus and Urinary Tract Infection: Spectrum of Uropathogens and their Antibiotic Sensitivity

Acharya

Bogati

Shrestha

et al. 2015

J. Manmohan Memorial Inst. Health. Sci.

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The incidence of urinary tract infections (UTIs) is common in both diabetic and non diabetic patients. Since the microorganisms causing UTI vary in their susceptibility to antimicrobials from place to place and time to time, hence constant screening of trends and susceptibility pattern of predominant organisms against antimicrobials is essential. The study aims to determine the spectrum of uropathogens and antibiotic sensitivity pattern in both diabetic and non diabetic patients with clinically suspected UTI .A prospective cross sectional study was conducted during period of February 2013 to July 2013 among 90 diabetic and 90 non diabetic patients attending Dhulikhel Hospital-Kathmandu University Hospital, Dhulikhel, Kavre (DH-KUH). All samples and isolates were investigated by standard laboratory procedures. A total of 55 (30.5%) samples showed significant growth. No significant difference among culture positivity rate was noted between diabetic and non diabetic patients (34.5% Vs 26.7%). Escherichia coli was the most frequent organism (64.5% in diabetic and 66.7% non diabetic) followed by Klebsiella sps (22.6% in diabetic and 12.5% in non diabetic). Gentamycin and nitrofurantoin were highly sensitive to E. coli isolated in diabetic patients among the tested antimicrobials followed by cotrimoxazole, norfloxacin and ciprofloxacin. Least sensitivity rate was observed with ampicillin and cephalexin. However, no difference was noted on the sensitivity pattern of the antimicrobials among E. coli isolated between diabetic and non diabetic patients.In this study high proportion of gram negative bacilli with predominant uropathogen being E. coli was noted. Irrespective of the status of diabetes, Staphylococcus sps and Pseudomonas sps were not isolated from UTI patients in our study. The isolation of organisms and their resistance pattern was almost similar between diabetic and non diabetic patients.Key words: Antibiotic Susceptibility Test, Diabetes mellitus, Urinary Tract Infection Introduction:

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“…Bacteremia secondary to UTI and pyelonephritis may also be more common in patients with diabetes. Also of importance is the fact that many diabetic patients are infected with non-Escherichia coli species, in particular Klebsiella, other gram-negative rods, enterococci, and group B streptococci (96,103). Additionally, urinary infections and ASB with Candida albicans occur commonly in diabetic women but infrequently in other women (91).…”

Section: Female Sexual Dysfunctionmentioning

confidence: 99%

Urologic Complications of Diabetes

et al. 2005

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Epidemiology of Klebsiella bacteraemia: a case control study using Escherichia coli bacteraemia as control

Cited by 93 publications

References 36 publications

Prevalence, antibiotic susceptibility profiles and ESBL production in Klebsiella pneumoniae and Klebsiella oxytoca among hospitalized patients

Prevalence, antibiotic susceptibility profiles and ESBL production in Klebsiella pneumoniae and Klebsiella oxytoca among hospitalized patients

Diabetes mellitus and Urinary Tract Infection: Spectrum of Uropathogens and their Antibiotic Sensitivity

Urologic Complications of Diabetes

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