Epidemiology of systemic vasculitis: A ten-year study in the United Kingdom

Watts, Richard A.; Lane, Suzanne; Bentham, Graham; Scott, David G. I.

doi:10.1002/1529-0131(200002)43:2<414::aid-anr23>3.0.co;2-0

Cited by 433 publications

(241 citation statements)

References 15 publications

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“…In our population, ANCA and AAV were present in 11% and 4%, respectively, of patients treated with antithyroid drugs. Prevalence of primary systemic vasculitis (Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome, polyarteritis nodosa) has been estimated at 144.5/million (0.01%) in a population comparable with the general population in Groningen (30). Therefore, a prevalence of AAV of 4% in our patients treated with antithyroid drugs clearly suggests a relationship between these drugs and the presence of AAV.…”

Section: Discussionmentioning

confidence: 57%

Occurrence of antineutrophil cytoplasmic antibodies and associated vasculitis in patients with hyperthyroidism treated with antithyroid drugs: A long‐term followup study

Slot¹,

Links²,

Stegeman³

et al. 2005

Arthritis & Rheumatism

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Section: Discussionmentioning

confidence: 57%

Occurrence of antineutrophil cytoplasmic antibodies and associated vasculitis in patients with hyperthyroidism treated with antithyroid drugs: A long‐term followup study

Slot¹,

Links²,

Stegeman³

et al. 2005

Arthritis & Rheumatism

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“…In the 1980s, the incidence of AASV was 10 per 10 6 in the United Kingdom, but after ANCA were clinically available in the 1990s, the incidence of AASV increased to 20 per 10 6 in the United Kingdom (4,11,12,13,15). The incidence of AASV in the Chinese population is unknown.…”

Section: Discussionmentioning

confidence: 91%

“…The first difference concerned sexual predominance. Many reports revealed that Caucasian patients were male predominant (12,13), while for the Chinese patients, males and females are equally affected; however, for the Chinese patients under 20 years of age, the females are clearly predominant (4:1), a finding that needs to be further studied. The second concerned antigenic predominance.…”

Section: Discussionmentioning

confidence: 99%

Detection Rate and Antigenic Specificities of Antineutrophil Cytoplasmic Antibodies in Chinese Patients with Clinically Suspected Vasculitis

Zhao

Wang

2004

Clin Vaccine Immunol

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The detection rate of antineutrophil cytoplasmic antibodies (ANCA) in Chinese patients with clinically suspected small vessel vasculitis was investigated, and their antigen specificity and demographic features were analyzed. A number of sera (n ‫؍‬ 5,604) sent to our referral laboratory for ANCA screening were tested by indirect immunofluorescence (IIF), enzyme-linked immunosorbent assays (ELISAs) for myeloperoxidase (MPO)-and proteinase 3 (PR3)-ANCA. Then the IIF-ANCA-positive sera that were negative for MPO-and PR3-ANCA were further tested by antigen-specific ELISA by using other five highly purified known ANCA antigens as solid-phase ligands. The known antigens included bactericidal/permeability-increasing protein (BPI), human leukocyte elastase (HLE), lactoferrin, cathepsin G, and azurocidins. Of the 5,604 sera, 267 (4.76%) sera were IIF-ANCA positive and 390 (7%) were antinuclear antibody (ANA) positive in the IIF assay. Of the IIF-positive samples, 213 were anti-MPO positive, 32 were anti-PR3 positive, and five cases were positive for both. Of the 48 sera positive for IIF-ANCA but negative for MPO-and PR3-ANCA, 13 sera (27%) recognized other target antigens, 7 sera recognized BPI, 5 recognized HLE, 1 recognize cathepsin G, and 1 recognized azurocidin. None of the sera recognized lactoferrin, and one serum sample recognized both BPI and HLE. The majority of ANCA-positive patients presented in summer or winter. There was no difference in gender (male/female ratio, 1:1.12) in ANCA-positive patients with a mean age of 53.1 years. The male/female ratio was 1.17:1 for patients over 60 years of age; however, it was 1:4 for patients under 20 years of age. We conclude that ANCA-related diseases are not rare in China, and the major antigens are MPO and PR3. When the IIF technique is used to detect ANCA, ANA should be carefully distinguished.The systemic vasculitides comprise a spectrum of clinical syndromes united by a common pathology consisting of a primary inflammation and necrosis of blood vessels. Antineutrophil cytoplasmic antibodies (ANCA) are serological markers for certain primary vasculitic diseases, including Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome, and idiopathic pauci-immune necrotizing glomerulonephritis. These diseases were called ANCA-associated systemic vasculitis (AASV) (3, 7). ANCA can be identified by using indirect immunofluorescence (IIF) techniques and by overlay serum from patients with suspected vasculitis on alcohol-fixed human polymorphonuclear leukocytes (PMN). This procedure produces two staining patterns: a cytoplasmic pattern (C-ANCA) and a perinuclear pattern (P-ANCA) (2, 9). Although proteinase 3 (PR3) and myeloperoxidase (MPO) are the major C-ANCA and P-ANCA antigens (2, 9), several other neutrophil granule constituents can also be recognized by ANCA-positive sera, including bactericidal/permeability-increasing protein (BPI), cathepsin G (CG), lactoferrin, human leukocyte elastase (HLE), and azurocidin (16,17,18).AASV are common autoimmune disorder...

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“…Studies from England, Spain, and Scandinavia have shown that the overall annual incidence of primary systemic vasculitis is approximately 20 cases per million (42)(43)(44). In various populations, certain types of vasculitis appear more frequently, suggesting that either genetic or environmental factors may be associated with the prevalence of vasculitis in certain populations.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and incidence in patients with autoimmune rheumatic diseases: A nationwide population‐based study in Taiwan

See

Kuo

et al. 2013

Arthritis Care & Research

117

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Epidemiology of systemic vasculitis: A ten-year study in the United Kingdom

Abstract: In our study population, the annual incidence of PSV is slowly increasing with time and the incidence is greatest in the elderly.

Cited by 433 publications

References 15 publications

Occurrence of antineutrophil cytoplasmic antibodies and associated vasculitis in patients with hyperthyroidism treated with antithyroid drugs: A long‐term followup study

Occurrence of antineutrophil cytoplasmic antibodies and associated vasculitis in patients with hyperthyroidism treated with antithyroid drugs: A long‐term followup study

Detection Rate and Antigenic Specificities of Antineutrophil Cytoplasmic Antibodies in Chinese Patients with Clinically Suspected Vasculitis

Prevalence and incidence in patients with autoimmune rheumatic diseases: A nationwide population‐based study in Taiwan

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