Epidermal curettage technique (ECT) for tissue harvest from the donor area for melanocyte autologous grafting in cases of vitiligo

Filho, Carlos D' Apparecida Santos Machado; Timoner, Fábio

doi:10.1590/abd1806-4841.20142865

Cited by 6 publications

(7 citation statements)

References 8 publications

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“…Epidermal cells can be obtained by resection of a thin layer of skin, using a flexible blade, through the epidermal curettage or through manual dermabrasion. 18 , 21 , 24 The receptor area can be prepared by manual or motorized dermabrasion device, CO 2 lasers, liquid nitrogen, among others. 25 One recent article published by Al-Hadidi et al (2016) suggests that post-operative care is also essential to the success of the treatment.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of treatment response to autologous transplantation of noncultured melanocyte/keratinocyte cell suspension in patients with stable vitiligo

Ramos

Ramos³

2017

An. Bras. Dermatol.

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BackgroundVitiligo is a chronic disease characterized by the appearance of achromic macules caused by melanocyte destruction. Surgical treatments with melanocyte transplantation can be used for stable vitiligo cases. ObjectivesTo evaluate treatment response to the autologous transplantation of noncultured epidermal cell suspension in patients with stable vitiligo.MethodsCase series study in patients with stable vitiligo submitted to noncultured epidermal cell suspension transplantation and evaluated at least once, between 3 and 6 months after the procedure, to observe repigmentation and possible adverse effects. The maximum follow-up period for some patients was 24 months.ResultsOf the 20 patients who underwent 24 procedures, 25% showed an excellent rate of repigmentation, 50% good repigmentation, 15% regular, and 10% poor response. The best results were observed in face and neck lesions, while the worst in extremity lesions (88% and 33% of satisfactory responses, respectively). Patients with segmental vitiligo had a better response (84%) compared to non-segmental ones (63%). As side effects were observed hyperpigmentation of the treated area and the appearance of Koebner phenomenon in the donor area.Study limitationsSome limitations of the study included the small number of patients, a subjective evaluation, and the lack of long-term follow-up on the results. CONCLUSION: Noncultured epidermal cell suspension transplantation is efficient and well tolerated for stable vitiligo treatment, especially for segmental vitiligo on the face and neck.

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Section: Discussionmentioning

confidence: 99%

“… 15 The transplantation of epidermal cell suspension (melanocytes and keratinocytes) has been used and documented by different groups, primarily in Asia, the Middle East, and Europe, as well as in some groups in Brazil. 13 - 18 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of treatment response to autologous transplantation of noncultured melanocyte/keratinocyte cell suspension in patients with stable vitiligo

Ramos

Ramos³

2017

An. Bras. Dermatol.

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“…Surgical techniques have proven to be effective in stable cases, and melanocyte transfer may be performed by punch minigrafting, split‐thickness skin grafting, hair follicle transplantation, suction blisters, epidermal curettage techniques and cultured and non‐cultured autologous melanocytes. The previous surgical and cultured techniques can be time‐consuming and, in some cases, aesthetically unsatisfying or painful for the patients . In recent years, new non‐cultured autologous epidermal techniques have been developed with similar results to the cultured melanocytes techniques, but are simpler, less expensive and less time‐consuming.…”

Section: Introductionmentioning

confidence: 99%

Epidermal skin grafting in vitiligo: a pilot study

Janowska

Dini

Panduri

et al. 2016

International Wound Journal

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Vitiligo is a multifactorial acquired dermatosis characterised by achromic or hypochromic macules and by the absence of functioning melanocytes. Treatment depends on the extent of the affected areas and on disease activity. Surgical techniques have proven to be effective in stable cases but can be time-consuming and, in some cases, aesthetically unsatisfying or painful for the patients. The aim of the study was to assess the clinical safety and effectiveness of a new automatic epidermal skin harvesting device in patients with stable localised vitiligo over a minimum 12-month period. This new system (CELLUTOME™ Epidermal Harvesting System, KCI, an ACELITY Company, San Antonio, TX) is a commercially available epidermal skin harvesting system that can be used without local anaesthesia or other pre-treatments and has been shown to have low rates of donor site morbidity. Epidermal skin grafts can used in patients with acute and hard to heal chronic wounds, burns and stable vitiligo. The use of advanced therapies may improve the quality of life, have cost benefits and accelerate re-pigmentation of patients with vitiligo. In our preliminary study, this system was seen to be a safe and efficacious means of harvesting epidermal micrografts containing melanocytes for use in patients with stable vitiligo unresponsive to standard therapies.

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“…The curettage technique has been known for over several dozen years, yet it was not initially considered one of the possible forms of tissue grafting in the course of vitiligo [44]. However, the clinical effects associated with the use of this method prompted researchers to further analyze this therapeutic option [45].…”

Section: Epidermal Curettage Technique (Ect)mentioning

confidence: 99%

Surgical Treatment of Vitiligo

Frączek

Kasprowicz-Furmańczyk

Placek

et al. 2022

IJERPH

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Vitiligo is described as a dermatological condition characterized by pigmentation disorders in both the skin and mucous membranes. Clinically, this disease is characterized by the presence of well-defined white areas of various shapes and sizes, which are a manifestation of a reduced number of melanocytes. Due to the fact that vitiligo can be a significant cosmetic problem for patients, a number of methods are currently available to help fight for a better skin appearance. If all the available non-invasive procedures turn out to be ineffective, surgery can help, which is a very good alternative in the case of difficult-to-treat but stable changes. Both the development of new techniques and modifications to the already available treatment of cell and tissue transplantation give hope to numerous patients around the world. The effectiveness of a particular method is determined by its appropriate selection depending on the lesions undergoing therapy. Each form of surgical intervention has its advantages and disadvantages, which, along with the location or size of the treated hypopigmentation area, should be analyzed by a doctor and discussed with their patient. This article is an overview of the currently available methods of surgical treatment of vitiligo and a comparison of their pros and cons.

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Epidermal curettage technique (ECT) for tissue harvest from the donor area for melanocyte autologous grafting in cases of vitiligo

Cited by 6 publications

References 8 publications

Evaluation of treatment response to autologous transplantation of noncultured melanocyte/keratinocyte cell suspension in patients with stable vitiligo

Evaluation of treatment response to autologous transplantation of noncultured melanocyte/keratinocyte cell suspension in patients with stable vitiligo

Epidermal skin grafting in vitiligo: a pilot study

Surgical Treatment of Vitiligo

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