Epidermal Growth Factor and Epidermal Growth Factor Signaling Attenuate Laser-Induced Melanogenesis

Abstract

Our results support EGF as a candidate target for development of antimelanogenic agents in PIH.

Effect of an Epidermal Growth Factor-Containing Cream on Postinflammatory Hyperpigmentation After Q-Switched 532-nm Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment

“…Recently, EGF was found to decrease inflammation-induced melanogenesis. 17 Yun and colleagues confirmed that human melanocytes express EGFRs and respond to EGF through the extracellular signal-regulated kinases signaling pathway. Extracellular signalregulated kinases is a downstream mediator of EGFR, 18 and its activation reduces melanin synthesis through downregulation of microphthalmiaassociated transcription factor.…”

The effects of recombinant human epidermal growth factor containing ointment on wound healing and post inflammatory hyperpigmentation prevention after fractional ablative skin resurfacing: A split‐face randomized controlled study

“…These events is suggested to take part in the formation of PIH. 25,26 In addition, vehicle type may affect the filling of the column of wound or channels created by the CO 2 laser.…”

Tranexamic Acid Diminishes Laser-Induced Melanogenesis

“…2). Several recent reports demonstrate the usefulness of LT-KCM for evaluating changes of melanogenic cytokine profiles14,15. Although LT-KCM has an intrinsic limitation in representing PIH, it adequately reproduces the intense inflammatory conditions leading to melanogenesis.…”